Molecular epidemiology investigation of β-thalassemia in Zhongshan City, Guangdong Province, People's Republic of China

Hemoglobin

Volumn 34, Issue 1, 2010, Pages 55-60

  Zhang, Cui Mei ^a   Wang, Ying ^a   Gao, Li Shao ^b   Gao, Jian Hui ^a   He, Xiao Ling ^a   Feng, Hua Jun ^a   Liao, Jia Luo ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Children's Health Association of Zhongshan City   (China)

Author keywords

Thalassemia ( thal); Thalassemia ( thal); Epidemiology; Mutations; Prevention

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; BETA THALASSEMIA; CHINA; CODON; DNA DETERMINATION; GENE FREQUENCY; GENE MUTATION; GENETIC COUNSELING; HUMAN; MAJOR CLINICAL STUDY; MORBIDITY; PRENATAL DIAGNOSIS; PREVALENCE;

BETA-THALASSEMIA; CHINA; DNA; HUMANS; MOLECULAR EPIDEMIOLOGY; PHENOTYPE; POINT MUTATION;

EID: 76449117748     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630260903547724     Document Type: Article

References (10)

1. Weatherall DJ, Clegg JB. The Thalassaemia Syndromes, 4th ed. Oxford: Blackwell Science, 2001.
2. Kazazian HH Jr. The thalassemia syndromes: molecular basis and prenatal diagnosis in 1990. Semin Hematol. 1990;27(3):209-228.
3. Olivieri NF. The b-Thalassemias. N Engl J Med. 1999;341(2):99-109.
4. Modell B, Petrou M, Ward RH, et al. Effect of fetal diagnostic testing on birth-rate of thalassaemia major in Britain. Lancet. 1984;2(8416):1383-1386.
5. Zeng YT, Huang SZ. Disorders of haemoglobin in China. J Med Genet. 1987;24(10):578-583.
6. Xu XM, Zhou YQ, Luo GX, et al. The prevalence and spectrum of a and b thalassaemia in Guangdong Province: implications for the future health burden and population screening. J Clin Pathol. 2004;57(5):517-522
7. Li Z, Li F, Li M, Guo R, Zhang W. The prevalence and spectrum of thalassemia in Shenzhen, Guangdong Province, People's Republic of China. Hemoglobin. 2006;30(1):9-14.
8. Pan HF, Long GF, Li Q, et al. Current status of thalassemia in minority populations in Guangxi, China. Clin Genet. 2007;71(5):419-426.
9. Ma SK, Ha SY, Chan AY, Chan GC, Lau YL, Chan LC. Two novel b-thalassemia alleles in the Chinese: the IVS-II-2 (-T) and nucleotide +8 (C - >T) b-globin gene mutations. Hemoglobin. 2000;24(4):327-332.
10. Chui DHK, Waye JS. Hydrops fetalis caused by a-thalassemia: an emerging health care problem. Blood. 1998;91(7):2213-2222.