Antiobesity and hypolipidemic effects of polyphenol-rich longan (dimocarpus longans lour.) flower water extract in hypercaloric-dietary rats

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 3, 2010, Pages 2020-2027

  Yang, Deng Jye ^a,b   Chang, Yuan Yen ^a,b   Hsu, Chin Lin ^a,b   Liu, Cheng Wei ^c   Lin, Y I Ling ^a   Lin, Y U Huei ^a   Liu, Kai Cheng ^a   Chen, Y I Chen ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c MINGDAO UNIVERSITY   (Taiwan)

Author keywords

Antiobesity; Hypolipidemic effect; Lipid homeostasis; Longan flower water extract; Pancreatic lipase activity; Polyphenol

Indexed keywords

ANTILIPEMIC AGENT; FLAVONOID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; FAT INTAKE; FLOWER; GENE EXPRESSION; GENETICS; HUMAN; LIPID METABOLISM; MALE; METABOLISM; OBESITY; RANDOMIZATION; RAT; SAPINDACEAE; SPRAGUE DAWLEY RAT;

ANIMALS; ANTILIPEMIC AGENTS; DIETARY FATS; DISEASE MODELS, ANIMAL; FLAVONOIDS; FLOWERS; GENE EXPRESSION; HUMANS; LIPID METABOLISM; MALE; OBESITY; PHENOLS; PLANT EXTRACTS; PPAR ALPHA; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SAPINDACEAE; TRIGLYCERIDES;

DIMOCARPUS LONGAN; RATTUS;

EID: 76449106605     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf903355q     Document Type: Article

References (43)

1. Donahue, R. P.; Abbott, R. D.; Bloom, E.; Reed, D. M. Central obesity and coronary heart disease in men. Lancet 1987, 11, 821-824.
2. Cooke, D.; Bloom, S. The obesity pipeline: current strategies in the development of anti-obesity drugs. Nat. Rev. Drug Discovery 2006, 5, 919-931. (Pubitemid 44660605)
3. Halford, J. Obesity drugs in clinical development. Curr. Opin. Invest. Drugs 2006, 7, 312-318.
4. Birari, R. B.; Bhutani, K. K. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discovery Today 2007, 12, 879-889.
5. Prior, R. L.; Cao, G. Flavonoids: Diet and health relationships. Nutr. Clin. Care 2000, 3, 279-288.
6. Yang, M. H.; Wang, C. H.; Chen, H. L. Green, oolong and black tea extracts module lipid metabolism in hyperlipidemia rats fed highsucrose diet. J. Nutr. Biochem. 2001, 12, 14-20.
7. Chen, C. C.; Hsu, J. D.; Wang, S. F.; Chiang, H. C.; Yang, M. Y.; Kao, E. S.; Ho, Y. C.; Wang, C. J. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J. Agric. Food Chem. 2003, 51, 5472-5477.
8. Osada, K.; Suzuki, T.; Kawakami, Y.; Senda, M.; Kasai, A.; Sami, M.; Ohta, Y.; Kanda, T.; Ikeda, M. Dose-dependent hypocholesterolemic actions of dietary apple phenol in rats fed cholesterol. Lipids 2006, 47, 133-139.
9. Ho, S. C.; Hwang, L. S.; Shen, Y. J.; Lin, C. C. Suppressive effect of a proanthocyanidin-rich extract from longan (Dimocarpus long Lour.) flowers on nitric oxide production in LPS-stimulate macrophage cells. J. Agric. Food Chem. 2007, 55, 10664-10670.
10. Jemai, H.; Bouaziz, M.; Fki, I.; EI Feki, A.; Sayadi, S. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivativerich extracts from Chemlali olive leaves. Chem. Biol. Interact. 2008, 176, 88-98.
11. Yang, D. J.; Chang, Y. Y.; Hsu, C. L.; Liu, C. W.; Wang, Y.; Chen, Y. C. Protective effect of a litchi (Litchi chinensis Sonn.)-flowerwater-extract on cardiovascular health in a high-fat/cholesteroldietary hamsters. Food Chem. 2010, 119, 1457-1464.
12. Yoshikawa, M.; Shimoda, H.; Nishida, N.; Takada, M.; Matsuda, H. Salacia reticulata and its polyphenols constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J. Nutr. 2002, 132, 1819-1824. (Pubitemid 34742862)
13. Yoshizumi, K.; Hirano, K.; Ando, H.; Hirai, Y.; Ida, Y.; Tsuji, T.; Tanaka, T.; Satouchi, K.; Terao, J. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. J. Agric. Food Chem. 2006, 54, 335-341. (Pubitemid 43301248)
14. Horton, J. D.; Goldstein, J. L.; Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109, 1125-1131.
15. Matsuo, K.; Arai, H.; Muto, K.; Fukaya, M.; Sato, T.; Mizuno, A.; Sakuma, M.; Yamanaka-Okumura, H.; Sasaki, H.; Yamamoto, H.; Taketani, Y.; Doi, T.; Takeda, E. The anti-obesity effect of the palatinose-based formula inslow is likely due to an increase in the hepatic PPAR-alpha and adipocyte PPAR-gamma gene expressions. J. Clin. Biochem. Nutr. 2007, 40, 234-241. (Pubitemid 46984218)
16. Seo, Y. S.; Kim, J. H.; Jo, N. Y.; Choi, K. M.; Baik, S. H.; Park, J. J.; Kim, J. S.; Byun, K. S.; Bak, Y. T.; Lee, C. H.; Kim, A.; Yeon, J. E. PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. J. Gastroenterol. Hepatol. 2008, 23, 102-109.
17. Liu, S. C.; Lin, J. T.; Wang, C. K.; Chen, H. Y.; Yang, D. J. Antioxidant properties of various solvent extracts from lychee (Litchi chinenesis Sonn.) flowers. Food Chem. 2009, 114, 577-581.
18. Shyu, Y. S.; Lin, J. T.; Chang, Y. T.; Chiang, C. J.; Yang, D. J. Evaluation of antioxidant ability of ethanolic extract from dill (Anethum graveolens L) flower. Food Chem. 2009, 115, 515-521.
19. Klein, B. P.; Perry, A. K. Ascorbic acid and vitamin A activity in selected vegetables from different geographical areas of United State. J. Food Sci. 1982, 47, 941-945.
20. Askun, T.; Turnen, G.; Satil, F.; Ates, M. In vitro activity of methanol extracts of plants used as spices against Mycobacterium tuberculosis and other bacteria. Food Chem. 2009, 116, 289-294.
21. Levin, B. E.; Dunn-Meynell, A. A. Reduced central leptin sensitivity in rats with diet-induced obesity. Am. J. Physiol. 2002, 283, R941-948.
22. Woo, M. N.; Bok, S. H.; Lee, M. K.; Kim, H. J.; Jeon, S. M.; Do, G. M.; Shin, S. K.; Ha, T. Y.; Choi, M. S. Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diets. J. Med. Food 2008, 11, 169-178.
23. Tzang, B. S.; Yang, S. F.; Fu, S. G.; Yang, H. C.; Sun, H. L.; Chen, Y. C. Effects of dietary flaxseed oil on cholesterol metabolism of hamsters. Food Chem. 2009, 114, 1450-1455.
24. Freund, R. J.; Wilson, W. J. Principles of Inference in Statistical Methods; Academic Press: San Diego, CA, 1997; pp 142-145.
25. Marrsset-Baglieri, A.; Fromentin, G.; Tomé, D.; Bensaid, A.; Makkarios, L.; Even, P. C. Increasing the protein content in a carbohydrate-free diet enhanced fat loss during 35% but not 75% energy restriction in rats. J. Nutr. 2004, 134, 2646-2652. (Pubitemid 39315267)
26. Stubbs, R. J.; Whybrow, S. Energy density, diet composition and palatability: influences on overall food energy intake in humans. Physiol. Behav. 2004, 81, 755-764. (Pubitemid 38845043)
27. Westerterp-Plantenga, M. S. Effects of energy density of daily food intake on long-term energy intake. Physiol. Behav. 2004, 81, 765-771. (Pubitemid 38845044)
28. Chen, W. P; Ho, B. Y.; Lee, C. L.; Lee, C. H.; Pan, T. M. Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet. Int. J. Obes. 2008, 32, 1694-1704.
29. Hsu, C. L.; Wu, C. H.; Huang, S. L.; Yen, G. C. Phenolic Compounds Rutin and o-Coumaric Acid Ameliorate Obesity Induced by High-Fat Diet in Rats. J. Agric. Food Chem. 2009, 57,425-431.
30. Jean, C.; Rome, S.; Mathe, V.; Huneau, J. F.; Aattouri, N.; Fromentin, G.; Achagiotis, C. L.; Tomé, D. Metabolie evidence for adaptation to a high protein diets in rats. J. Nutr. 2001, 131, 91-98. (Pubitemid 32060628)
31. Hsieh, M. C.; Shen, Y. J.; Kuo, Y. H.; Hwang, L. S. Antioxidative activity and active components of longan (Dimocarpus longan Lour.) flower extracts. J. Agric. Food Chem. 2008, 56, 7010-7016.
32. Tsai, H. Y.; Wu, L. Y.; Hwang, L. S. Effect of a proanthocyanidinrich extract from longan flower on markers of metabolic syndrome in fructose-fed rats. J. Agric. Food Chem. 2008, 56, 11018-11021.
33. He, Q.; Ly, Y.; Yao, K. Effects of tea polyphenols on the activities of α-amylase, pepsin, trypsin and lipase. Food Chem. 2006, 101,1178-1182. (Pubitemid 44416505)
34. Sugiyama, H.; Akazome, Y.; Shoji, T.; Yamaguchi, A.; Yasue, M.; Kanda, T.; Ohtake, Y. Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J. Agric. Food Chem. 2007, 55, 4606-4609.
35. Ikeda, I.; Hamamoto, R.; Uzu, K.; Imaizumi, K.; Nagao, K.; Yanagita, T.; Suzuki, Y.; Kobayashi, M.; Kakuuda, T. Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats. Biosci., Biotechnol, Biochem. 2005, 69, 1049-1053.
36. Lam, C. K.; Zang, Z.; Yu, H.; Tsang, S. Y.; Huang, Y.; Chen, Z. Y. Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non-HDL to HDL cholesterol. Mol. Nutr. Food Res. 2008, 52, 950-958.
37. Liu, L. K.; Chou, F. P.; Chen, Y. C.; Chyau, C. C.; Chen, C. C.; Wang, C. J. Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo. J. Agric. Food Chem. 2009, 57,7605-7611.
38. Matsuo, K.; Arai, H.; Muto, K.; Fukaya, M.; Sato, T.; Mizuno, A.; Sakuma, M.; Yamanaka-Okumura, H.; Sasaki, H.; Yamamoto, H.; Taketani, Y.; Doi, T.; Takeda, E. The anti-obesity effect of the palatinose-based formula inslow is likely due to an increase in the hepatic PPAR-alpha and adipocyte PPAR-gamma gene expressions. J. Clin. Biochem. Nutr. 2007, 40, 234-241. (Pubitemid 46984218)
39. Seo, Y. S.; Kim, J. H.; Jo, N. Y.; Choi, K. M.; Baik, S. H.; Park, J. J.; Kim, J. S.; Byun, K. S.; Bak, Y. T.; Lee, C. H.; Kim, A.; Yeon, J. E. PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. J. Gastroenterol. Hepatol. 2008, 23, 102-109.
40. Kühnau, J. The flavonoids: a class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet 1976, 24, 117-191.
41. Scalbert, A.; Williamson, G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000, 130, 2073S-2085S.
42. Reagan-Shaw, S.; Nihal, M.; Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659-661. (Pubitemid 351348146)
43. Vaidyanathan, J. B.; Walle, T. Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes. Drug Metab. Dispos. 2002, 30, 897-903.