Risk of Fatal Arrhythmic Events in Long QT Syndrome Patients After Syncope

Journal of the American College of Cardiology

Volumn 55, Issue 8, 2010, Pages 783-788

  Jons, Christian ^a   Moss, Arthur J ^a   Goldenberg, Ilan ^a   Liu, Judy ^a   McNitt, Scott ^a   Zareba, Wojciech ^a   Qi, Ming ^a   Robinson, Jennifer L ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

beta blockers; long QT syndrome; sudden cardiac death; syncope

Indexed keywords

ATENOLOL; METOPROLOL; NADOLOL; PROPRANOLOL DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; CARDIAC PATIENT; CARDIOVASCULAR RISK; CHILD; DEFIBRILLATOR; DISEASE SEVERITY; FEMALE; GENOTYPE; HEART ARREST; HEART ARRHYTHMIA; HUMAN; INFANT; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; NEWBORN; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; QT INTERVAL; SUDDEN DEATH; SYNCOPE;

ADRENERGIC BETA-ANTAGONISTS; DEATH, SUDDEN, CARDIAC; DEFIBRILLATORS, IMPLANTABLE; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; LONG QT SYNDROME; MALE; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SYNCOPE; TREATMENT OUTCOME;

EID: 76449098288     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.11.042     Document Type: Article

References (19)

1. Moss A.J., Schwartz P.J., Crampton R.S., et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation 84 (1991) 1136-1144
2. Moss A.J., Shimizu W., Wilde A.A., et al. Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation 115 (2007) 2481-2489
3. Priori S.G., Schwartz P.J., Napolitano C., et al. Risk stratification in the long-QT syndrome. N Engl J Med 348 (2003) 1866-1874
4. Goldenberg I., and Moss A.J. Long QT syndrome. J Am Coll Cardiol 51 (2008) 2291-2300
5. Goldenberg I., Mathew J., Moss A.J., et al. Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification. J Am Coll Cardiol 48 (2006) 1047-1052
6. Goldenberg I., Moss A.J., Peterson D.R., et al. Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation 117 (2008) 2184-2191
7. Goldenberg I., Moss A.J., Bradley J., et al. Long-QT syndrome after age 40. Circulation 117 (2008) 2192-2201
8. Hobbs J.B., Peterson D.R., Moss A.J., et al. Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA 296 (2006) 1249-1254
9. Sakaguchi T., Shimizu W., Itoh H., et al. Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long QT syndrome. J Cardiovasc Electrophysiol 19 (2008) 794-799
10. Moss A.J., and Schwartz P.J. 25th anniversary of the International Long-QT Syndrome Registry: an ongoing quest to uncover the secrets of long-QT syndrome. Circulation 111 (2005) 1199-1201
11. Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart 7 (1920) 353-370
12. Pannu H.K., Sullivan C., Lai S., and Fishman E.K. Evaluation of the effectiveness of oral beta-blockade in patients for coronary computed tomographic angiography. J Comput Assist Tomogr 32 (2008) 247-251
13. Degertekin M., Gemici G., Kaya Z., et al. Safety and efficacy of patient preparation with intravenous esmolol before 64-slice computed tomography coronary angiography. Coron Artery Dis 19 (2008) 33-36
14. Chatrath R., Bell C.M., and Ackerman M.J. Beta-blocker therapy failures in symptomatic probands with genotyped long-QT syndrome. Pediatr Cardiol 25 (2004) 459-465
15. Vincent G.M., Schwartz P.J., Denjoy I., et al. High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures.". Circulation 119 (2009) 215-221
16. Groh W.J., Silka M.J., Oliver R.P., Halperin B.D., McAnulty J.H., and Kron J. Use of implantable cardioverter-defibrillators in the congenital long QT syndrome. Am J Cardiol 78 (1996) 703-706
17. Viskin S. Implantable cardioverter defibrillator in high-risk long QT syndrome patients. J Cardiovasc Electrophysiol 14 (2003) 1130-1131
18. Zareba W., Moss A.J., Daubert J.P., Hall W.J., Robinson J.L., and Andrews M. Implantable cardioverter defibrillator in high-risk long QT syndrome patients. J Cardiovasc Electrophysiol 14 (2003) 337-341
19. Lin D.Y., and Wei L.J. The robust inference for the Cox proportional hazards model. J Am Stat Assoc 84 (1989) 1074-1078