The Utility of C4d, C9, and Troponin T Immunohistochemistry in Acute Myocardial Infarction

Archives of Pathology and Laboratory Medicine

Volumn 134, Issue 2, 2010, Pages 256-263

  Jenkins, Crystal P ^a   Cardona, Diana M ^a   Bowers, Jennifer N ^a   Oliai, Bahram R ^b   Allan, Robert W ^a   Normann, Sigurd J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b ProPath Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C9; PEPTIDE FRAGMENT; TROPONIN T;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD; FEMALE; HEART INFARCTION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PATHOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; COMPLEMENT C4B; COMPLEMENT C9; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PEPTIDE FRAGMENTS; TROPONIN T;

EID: 76449093380     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Rossen RD, Michael LH, Kagiyama A, et al. Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo. Circ Res. 1988;62(3):572-584.
2. Vakeva A, Morgan BP, Tikkanen I, Helin K, Laurila P, Meri S. Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. Am J Pathol. 1994;144(6):1357-1368.
3. Pinckard RN, Olson MS, Kelley RE, et al. Antibody-independent activation of human C1 after interaction with heart subcellular membranes. J Immunol. 1973;110(5):1376-1382.
4. Pinckard RN, Olson MS, Giclas PC, Terry R, Boyer JT, O'Rourke RA. Consumption of classical complement components by heart subcellular membranes in vitro and in patients after acute myocardial infarction. J Clin Invest. 1975;56(3): 740-750.
5. Kagiyama A, Savage HE, Michael LH, Hansen G, Entman ML, Rossen RD. Molecular basis of complement activation in ischemic myocardium: identification of specific molecules of mitochondrial origin that bind human C1q and fix complement. Circ Res. 1989;64(3):607-615.
6. Lagrand WK, Niessen HW, Wolbink G, et al. C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction. Circulation. 1997;95(1):97-103.
7. Yasojima K, Schwab C, McGeer EG, McGeer PL. Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circ Res. 1998;83(8):860-869.
8. Takemoto SK, Zeevi A, Feng S, et al. National conference to assess antibodymediated rejection in solid organ transplantation. Am J Transplant. 2004;4(7): 1033-1041.
9. Tan CD, Baldwin WM, Rodriguez ER. Update on cardiac transplantation pathology. Arch Pathol Lab Med. 2007;131(8):1169-1191.
10. Poelzl G, Ullrich R, Huber A, et al. Capillary deposition of the complement fragment C4d in cardiac allograft biopsies is associated with allograft vasculopathy. Transpl Int. 2005;18(3):313-317.
11. Chantranuwat C, Qiao J, Kobashigawa J, Hong L, Shintaku P, Fishbein M. Immunoperoxidase staining for C4d on paraffin-embedded tissue in cardiac allograft endomyocardial biopsies: comparison to frozen tissue immunofluorescence. Appl Immunohistochem Mol Morphol. 2004;12(2):166-171.
12. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined - a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36(3):959-969. (Pubitemid 30681627)
13. Lodge-Patch I. The ageing of cardiac infarcts and its influence on cardiac rupture. Br Heart J. 1951;13(1):37-42.
14. Mallory GK, White PD, Salcedo-Salgar J. The speed of healing of myocardial infarction: a study of the pathologic anatomy in 72 cases. Am Heart J. 1939; 18:647-671.
15. Schoen FJ. The heart. In: Kumar V, Abbas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Sanders; 2005:555-618.
16. Ritchie AC. Boyd's Textbook of Pathology. 9th ed. Malvern, PA: Lee and Febiger; 1990:677.
17. Fishbein MC, Meerbaum S, Rit J, et al. Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J. 1981;101(5):593-600.
18. Feldman S, Glagov S, Wissler RW, Hughes RH. Postmortem delineation of infarcted myocardium: coronary perfusion with nitro blue tetrazolium. Arch Pathol Lab Med. 1976;100(1):55-58.
19. Fishbein MC,Wang T, Matijasevic M, Hong L, Apple FS. Myocardial tissue troponins T and I: an immunohistochemical study in experimental models of myocardial ischemia. Cardiovasc Pathol. 2003;12(2):65-71.
20. Elliot RS, Baroldi G, Leone A. Necropsy studies in myocardial infarction with minimal or no coronary luminal reduction due to atherosclerosis. Circulation. 1974;49(6):1127-1131.
21. Ribeiro-Silva A, Martin CCS, Rossi MA. Is immunohistochemistry a useful tool in the postmortem recognition of myocardial hypoxia in human tissue with no morphological evidence of necrosis? Am J Forensic Med Pathol. 2002;23(1): 72-77.
22. Doran JP, Howie AJ, Townend JN, Bonser RS. Detection of myocardial infarction by immunohistological staining for C9 on formalin fixed, paraffin wax embedded sections. J Clin Pathol. 1996;49(1):34-37.
23. Campobasso CP, Dell'Erba AS, Addante A, Zotti F, Marzullo A, Colonna MF. Sudden cardiac death and myocardial ischemic indicators: a comparative study of four immunohistochemical markers. Am J Forensic Med Pathol. 2008; 29(2):154-161.
24. Nissen HWM, Lagrand WK, Visser CA, Meijer CJLM, Hack CE. Upregulation of ICAM-1 on cardiomyocytes in jeopardized human myocardium during infarction. Cardiovasc Res. 1999;41(3):603-610.
25. Schafer H, Mathey D, Hugo F, Bhakdi S. Deposition of the terminal C5b- 9 complement complex in infarcted areas of human myocardium. J Immunol. 1986;137(6):1945-1949.
26. Robert-Offerman SR, Leers MP, van Suylen RJ, Nap M, Daemen MJ, Theunissen PH. Evaluation of the membrane attach complex of complement for the detection of a recent myocardial infarction in man. J Pathol. 2000;191(1):48-53.
27. Bouchardy B, Majno G. Histopathology of early myocardial infarcts: a new approach. Am J Pathol. 1974;74(2):301-330.