Emergent Complications of the Newer Anticonvulsants

Journal of Emergency Medicine

Volumn 38, Issue 2, 2010, Pages 231-237

  Wade, Jeffrey F ^a   Dang, Chat V ^b   Nelson, Lowell ^b   Wasserberger, Jonathan ^b  

^a Memorial Hospital Gardena   (United States)

^b MLK Harbor Community Hospital   (United States)

Author keywords

complications; new anticonvulsants; overdose; side effects; treatment

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ACETAZOLAMIDE; ACTIVATED CARBON; ANOREXIGENIC AGENT; ANTICONVULSIVE AGENT; ANTINUCLEAR ANTIBODY; BICARBONATE; CARBAMAZEPINE; COTRIMOXAZOLE; ETIRACETAM; FELBAMATE; FOLIC ACID; GABAPENTIN; LAMOTRIGINE; LITHIUM; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; POTASSIUM; PREGABALIN; RECEPTOR; SODIUM; SODIUM CHLORIDE; SULFONAMIDE; TIAGABINE; TOPIRAMATE; VALPROATE SEMISODIUM; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

AGGRESSION; AGITATION; AGRANULOCYTOSIS; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ARTICLE; ATAXIA; AUTOIMMUNE DISEASE; BIPOLAR DISORDER; BLOOD DYSCRASIA; BRADYCARDIA; CAUSE OF DEATH; CLEFT LIP; CLINICAL FEATURE; CLINICAL PRACTICE; CLOSED ANGLE GLAUCOMA; COMA; CONFUSION; DISEASE EXACERBATION; DISEASE SEVERITY; DIZZINESS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONTRAINDICATION; DRUG ERUPTION; DRUG FATALITY; DRUG LABELING; DRUG OVERDOSE; DRUG SAFETY; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; EPILEPSY; EPILEPTIC STATE; FOOD AND DRUG ADMINISTRATION; HEADACHE; HEART VENTRICLE CONDUCTION; HEMODIALYSIS; HUMAN; HYPONATREMIA; HYPOTENSION; LETHARGY; LEUKOPENIA; METABOLIC ACIDOSIS; MYOPIA; NAUSEA; NAUSEA AND VOMITING; NEPHROLITHIASIS; NEUROPATHIC PAIN; NYSTAGMUS; OLIGOHYDROSIS; PALATE MALFORMATION; POSTMARKETING SURVEILLANCE; PREGNANCY; PRIORITY JOURNAL; PSYCHOSIS; RESPIRATION DEPRESSION; SEDATION; SEIZURE; SIDE EFFECT; STEVENS JOHNSON SYNDROME; SWEAT GLAND DISEASE; TACHYCARDIA; THROMBOCYTOPENIA; TREATMENT INDICATION; UNCONSCIOUSNESS; VISUAL HALLUCINATION; WEAKNESS; WEIGHT GAIN; WITHDRAWAL SYNDROME;

ACIDOSIS; AMINES; ANTICONVULSANTS; CARBAMAZEPINE; CYCLOHEXANECARBOXYLIC ACIDS; FRUCTOSE; GAMMA-AMINOBUTYRIC ACID; HUMANS; NIPECOTIC ACIDS; OVERDOSE; PIRACETAM; PSYCHOSES, SUBSTANCE-INDUCED; SEIZURES; TRIAZINES;

EID: 76449091320     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2008.03.032     Document Type: Article

References (22)

1. LaRoche S.M., and Helmers S.L. The new antiepileptic drugs. JAMA 291 (2004) 605-614
2. Wong I.C., and Lhatoo S.D. Adverse reactions to new anticonvulsant drugs. Drug Saf 23 (2000) 35-56
3. Sukumaran S., Herbert J., Tracey J., and Delanty S. Safety of newer generation anti-epileptic drugs in non-accidental overdose: an Irish population study. Seizure 14 (2005) 151-156
4. Sutphen S. New drugs; new overdoses. highlights from the American College of Emergency Physicians Meeting (ACEP) October 15-18, 2006; New Orleans, Louisiana Medscape Crit Care 2006;7: Posted 12/21/2006. http://www.medscape.com/viewarticle/548191
5. Gualteri T., and Johnson L. Comparative neurocognitive effects of 5 psychotropic anticonvulsants and lithium. Medscape General Medicine 8 (2006) 46. http://www.medscape.com/viewarticle/541762
6. Garris S.S., and Oles K.S. Impact of topiramate on serum bicarbonate concentrations in adults. Ann Pharmacother 39 (2005) 424-426
7. Walia K.S., Khan E.A., Ko D.H., Raza S.S., and Khan Y.N. Side effects of antiepileptics-a review. Pain Pract 4 (2004) 194-203
8. Asconape J.J. Some common issues in the use of antiepileptic drugs. Semin Neurol 22 (2002) 27-39
9. Cerminara C., Seri S., Bombardieri R., Pinci M., and Curatolo P. Hypohidrosis during topiramate treatment: a rare and reversible side effect. Pediatr Neurol 34 (2006) 392-394
10. Fakhoury T., Murray L., Seger D., McLean M., and Abou-Khalil B. Topiramate overdose: clinical and laboratory features. Epilepsy Behav 3 (2002) 185-189
11. Langman L.J., Kaliciak H.A., and Boone S.A. Fatal acute topiramate toxicity. Anal Toxicol 27 (2003) 323-324
12. Holmes L.B., Wyszynski D.F., Baldwin E.J., Habecker E., Glassman L.H., and Smith C.R. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy. Birth Defects Res A Clin Mol Teratol 76 (2006) 318
13. Lofton A.L., and Klein-Schwartz W. Evaluation of lamotrigine toxicity reported to poison centers. Ann Pharmacother 38 (2004) 1811-1815
14. Mylonakis E., Vittorio C.C., Hellick D.A., and Rounds S. Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome. Ann Pharmacother 33 (1999) 557-559
15. Sachdeo R.C., Wasserstein A., Mesenbrink P.J., and D'Souza J. Effects of oxcarbazepine on sodium concentration and water handling. Ann Neurol 51 (2002) 613-620
16. van Opstal J.M., Janknegt R., Cilissen J., L'Ortile W.H., Nel J.E., and De Heer F. Severe overdosage of the antiepileptic drug oxcarbazepine. Br J Clin Pharmacol 58 (2004) 329-331
17. Christensen J., Balsley T., Villadsen J., Heinsvig E.M., Dam M., and Poulsen J.H. Removal of 10-hydroxycarbazepine by plasmapheresis. Ther Drug Monit 23 (2001) 974-979
18. Mula M., Trimble M.R., Yuen A., Liu R.S., and Sander J.W. Psychiatric adverse effects during levetiracetam therapy. Neurology 61 (2003) 704-706
19. Barruetto Jr. F., Williams K., Howland M.A., Hoffman R.S., and Nelson L.S. A case of levetiracetam (Keppra) poisoning with clinical and toxicokinetic data. J Toxicol Clin Toxicol 40 (2002) 881-884
20. Klein-Schwartz W., Shepherd J.G., Gorman S., and Dahl B. Characterization of gabapentin overdose using a poison center case series. J Toxicol Clin Toxicol 41 (2003) 11-15
21. Spiller H.A., Winter M.L., Ryan M., et al. Retrospective evaluation of tiagapine overdose. Clin Toxicol (Phila) 43 (2005) 855-859
22. Eckhardt K.M., and Steinhoff B.J. Nonconvulsive status epilepticus in two patients receiving tiagapine treatment. Epilepsia 39 (1998) 671-674