Cyclic nucleotide phosphodiesterase-4 inhibitors: A promising therapeutic approach to premature birth?

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 117, Issue SUPPL., 2004, Pages

  Méhats, Céline ^a   Oger, Stéphanie ^a   Leroy, Marie Josèphe ^a  

^a INSERM   (France)

Author keywords

Phosphodiesterases PDE4 inhibitors

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC AMP PHOSPHODIESTERASE TYPE 4 B 2; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DESENSITIZATION; DRUG EFFECT; EXPLANT; FEEDBACK SYSTEM; GENE OVEREXPRESSION; HUMAN; LABOR; MYOMETRIUM; PREMATURITY; PRIORITY JOURNAL; SECOND MESSENGER; SMOOTH MUSCLE CONTRACTILITY; TOCOLYSIS; UTERUS CONTRACTILITY; UTERUS CONTRACTION;

EID: 7644240709     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2004.07.010     Document Type: Article

References (16)

1. R.L. Goldenberg, J.C. Hauth, and W.W. Andrews Intrauterine infection and preterm delivery N. Engl. J. Med. 342 2000 1500 1507
2. A.A. Abdel-Latif Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle Exp. Biol. Med. 226 2001 153 163
3. M. Conti, and S.L. Jin The molecular biology of cyclic nucleotide phosphodiesterases Prog. Nucleic Acid Res. Mol. Biol. 63 1999 1 38
4. M.J. Leroy, C. Lugnier, and J. Merezak Isolation and characterization of the rolipram-sensitive cyclic AMP-specific phosphodiesterase (type IV PDE) in human term myometrium Cell Signalling 6 1994 405 412
5. C. Mehats, G. Tanguy, and B. Paris Pregnancy induces a modulation of the cAMP phosphodiesterase 4-conformers ratio in human myometrium: consequences for the utero-relaxant effect of PDE4-selective inhibitors J Pharmacol Exp Ther. 292 2000 817 823
6. M. Conti, W. Richter, C. Mehats, G. Livera, J.Y. Park, and C. Jin Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling J. Biol. Chem. 278 2003 5493 5496
7. M.D. Houslay PDE4 cAMP-specific phosphodiesterases Prog. Nucleic. Acid. Res. Mol. Biol. 69 2001 249 315
8. M.J. Leroy, C. Mehats, and P. Duc-Goiran Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium Cell Signalling 11 1999 31 37
9. M.J. Leroy, I. Cedrin, M. Breuiller, Y. Giovagrandi, and F. Ferre Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term Biochem Pharmacol. 38 1989 9 15
10. G. Berg, R.G. Andersson, and G. Ryden Beta-adrenergic receptors in human myometrium during pregnancy: changes in the number of receptors after beta-mimetic treatment Am J Obstet Gynecol. 151 1985 392 396
11. C. Mehats, G. Tanguy, E. Dallot, D. Cabrol, F. Ferre, and M.J. Leroy Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? J. Clin. Endocrinol. Metab. 86 2001 5358 5365
12. E. Dallot, M. Pouchelet, N. Gouhier, D. Cabrol, F. Ferre, and M. Breuiller-Fouche Contraction of cultured human uterine smooth muscle cells after stimulation with endothelin-1 Biol. Reprod. 68 2003 937 942
13. C. Mehats, G. Tanguy, and E. Dallot Selective up-regulation of phosphodiesterase-4 cyclic adenosine 3′,5′-monophosphate (cAMP)-specific phosphodiesterase variants by elevated cAMP content in human myometrial cells in culture Endocrinology 140 1999 3228 3237
14. T.J. Torphy Phosphodiesterase isozymes: molecular targets for novel antiasthma agents Am. J. Respir. Crit. Care Med. 157 1998 351 370
15. S. Oger, C. Mehats, E. Dallot, F. Ferre, and M.J. Leroy Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2-cyclic adenosine 3'-5'-monophosphate-dependent pathway J. Clin. Endocrinol. Metab. 87 2002 5524 5531
16. S. Oger, C. Mehats, M.S. Barnette, F. Ferre, D. Cabrol, and M.J. Leroy Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors Biol. Reprod. 70 2 2004 458 464