Ribonuclease activity of cationic structures conjugated to lipophilic groups

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 6-7, 2004, Pages 977-981

  Koval'ov, N ^a   Kuznetsova, I ^a   Burakova, E ^a   Sil'nikov, V ^a   Zenkova, M ^a   Vlassov, V ^a  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

Author keywords

Artificial ribonuclease; Conformational stress; DABCO; RNA

Indexed keywords

1,4 DIAZABICYCLO[2.2.2]OCTANE; BENZENE; CATION; RIBONUCLEASE; RIBONUCLEASE T1;

AUTORADIOGRAPHY; CATALYSIS; CHEMICAL BOND; CONFERENCE PAPER; ENZYME PHOSPHORYLATION; LIPOPHILICITY; PROTEIN SECONDARY STRUCTURE; RNA CLEAVAGE; TRANSESTERIFICATION;

AUTORADIOGRAPHY; CATIONS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTERIFICATION; RIBONUCLEASES;

EID: 7644226771     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200026050     Document Type: Conference Paper

References (5)

1. Zenkova, M.; Beloglazova, N.; Sil'nikov, V.; Vlassov, V.; Giege, R. RNA cleavage by 1,4-diazabicyclo[2.2.2]octane-imidazole conjugates. Methods Enzymol. 2001, 341, 468-490.
2. Podyminogin, M.A.; Vlassov, V.V.; Giege, R. Synthetic RNA-cleaving molecules mimicking ribonuclease A active center. Design and cleavage of tRNA transcripts. Nucleic Acids Res. 1993, 25, 5950-5956.
3. Tyulkina, L.G.; Mankin, A.S. Inhibition of ribonuclease contamination in preparations of T4 RNA ligase, polynucleotide kinase and bacterial alkaline phosphatase with bentonite. Anal. Biochem. 1984, 138, 285-290.
4. Breslow, R.; Huang, D.-L.; Anslyn, E. On the mechanism of action of ribonucleases: dinucleotide cleavage catalyzed by imidazole and Zn2+. Proc. Natl. Acad. Sci. U. S. A. 1989, 86, 1746-1750.
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