Younger children with MS have a distinct CSF inflammatory profile at disease onset

Neurology

Volumn 74, Issue 5, 2010, Pages 399-405

  Chabas, D ^a   Ness, J ^b   Belman, A ^c   Yeh, E A ^d   Kuntz, N ^e   Gorman, M P ^f   Strober, J B ^a   De Kouchkovsky, I ^a   McCulloch, C ^g   Chitnis, T ^f   Rodriguez, M ^e   Weinstock Guttman, B ^d   Krupp, L B ^c   Waubant, E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UAB Center for Pediatric Onset Demyelinating Disease   (United States)

^c STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^d JACOBS NEUROLOGICAL INSTITUTE   (United States)

^e MAYO CLINIC   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; OLIGOCLONAL BAND;

ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID CYTOLOGY; CHILD; CONTROLLED STUDY; DATA BASE; FEMALE; HUMAN; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTE; MALE; MULTIPLE SCLEROSIS; NEUTROPHIL; PRIORITY JOURNAL;

EID: 76349099319     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181ce5db0     Document Type: Article

References (19)

1. Chabas D, Strober J, Waubant E. Pediatric multiple sclerosis. Curr Neurol Neurosci Rep 2008;8:434-441.
2. Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG. Acute disseminated encephalomyelitis, mul-tiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain 2000;12:2407-2422.
3. Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology 2002;59:1224-1231.
4. Banwell B, Krupp L, Kennedy J, et al. Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study. Lancet Neurol 2007;6:773-781.
5. Chabas D, Castillo-Trivino T, Mowry EM, Strober J, Glenn OA, Waubant E. Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? Neurology 2008;71:1090-1093.
6. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria." Ann Neurol 2005;58:840-846.
7. Freedman MS, Thompson EJ, Deisenhammer F, et al. Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement. Arch Neurol 2005;62:865-870.
8. Tintore M, Rovira A, Brieva L, et al. Isolated demyelinat-ing syndromes: comparison of CSF oligoclonal bands and different MR imaging criteria to predict conversion to CDMS. Mult Scler 2001;7:359-363.
9. Riikonen R. The role of infection and vaccination in the genesis of optic neuritis and multiple sclerosis in children. Acta Neurol Scand 1989;80:425-431.
10. Hanefeld F, Bauer HJ, Christen HJ, Kruse B, Bruhn H, Frahm J. Multiple sclerosis in childhood: report of 15 cases. Brain Dev 1991;13:410-416.
11. Ruggieri M, Polizzi A, Pavone L, Grimaldi LM. Multiple sclerosis in children under 6 years of age. Neurology 1999; 53:478-484.
12. Ghezzi A, Pozzilli C, Liguori M, et al. Prospective study of multiple sclerosis with early onset. Mult Scler 2002;8:115-118.
13. Pohl D, Rostasy K, Reiber H, Hanefeld F. CSF characteristics in early-onset multiple sclerosis. Neurology 2004;63: 1966-1967.
14. Atzori M, Battistella PA, Perini P, et al. Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients: a single centre prospective study. Mult Scler 2009;15:363-370.
15. Krupp LB, Banwell B, Tenembaum S. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology 2007;68:S7-S12.
16. Lee PA, Guo SS, Kulin HE. Age of puberty: data from the United States of America. APMIS 2001;109:81-88.
17. Mazor SS, McNulty JE, Roosevelt GE. Interpretation of traumatic lumbar punctures: who can go home? Pediatrics 2003;111:525-528.
18. Zeman D, Adam P, Kalistova H, Sobek O, Andel J, Andel M. Cerebrospinal fluid cytologic findings in multiple sclerosis: a comparison between patient subgroups Acta Cytol 2001;45:51-59.
19. Weiner HL. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann Neurol 2009;65:239-248.