Unexplained gastrointestinal symptoms and joint hypermobility: Is connective tissue the missing link?

Neurogastroenterology and Motility

Volumn 22, Issue 3, 2010, Pages

  Zarate, N ^a   Farmer, A D ^a   Grahame, R ^b   Mohammed, S D ^a   Knowles, C H ^a   Scott, S M ^a   Aziz, Q ^a,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c Princess Grace Hospital   (United Kingdom)

Author keywords

Benign joint hypermobility syndrome; Ehlers Danlos syndrome hypermobility type; Functional gastrointestinal disorders; Hereditary disorders of connective tissue; Joint hypermobility; Pathophysiology

Indexed keywords

DOMPERIDONE; ERYTHROMYCIN; LAXATIVE; PROTON PUMP INHIBITOR; RADIOISOTOPE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ANOREXIA NERVOSA; ARTHRALGIA; ARTICLE; BLOATING; CIRCADIAN RHYTHM; CONNECTIVE TISSUE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; ESOPHAGUS MOTILITY; FEMALE; FOOD INTAKE; FUNCTION TEST; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY DISORDER; GASTROINTESTINAL SYMPTOM; HUMAN; INTESTINE MOTILITY; JOINT HYPERMOBILITY; MAJOR CLINICAL STUDY; MALE; MANOMETRY; NAUSEA; OUTCOME ASSESSMENT; PATIENT REFERRAL; PRIORITY JOURNAL; QUESTIONNAIRE; RETROSPECTIVE STUDY; RHEUMATOLOGY; SCORING SYSTEM; STOMACH EMPTYING; VOMITING; WEIGHT REDUCTION;

ADOLESCENT; ADULT; AGED; CONNECTIVE TISSUE; FEMALE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL MOTILITY; HUMANS; JOINT INSTABILITY; MALE; MIDDLE AGED; PREVALENCE; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX;

EID: 76349094448     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01421.x     Document Type: Article

References (46)

1. Azpiroz F, Bouin M, Camilleri M et al. Mechanisms of hypersensitivity in IBS and functional disorders. Neurogastroenterol Motil 2007 19 : 62 88.
2. Hakim AJ, Grahame R. Non-musculoskeletal symptoms in joint hypermobility syndrome. Indirect evidence for autonomic dysfunction? Rheumatology (Oxford) 2004 43 : 1194 1195.
3. Hakim A, Grahame R. Joint hypermobility. Best Prac Res 2003 17 : 989 1004.
4. Matheis A, Martens U, Kruse J, Enck P. Irritable bowel syndrome and chronic pelvic pain: a singular or two different clinical syndrome? World J Gastroenterol 2007 13 : 3446 3455.
5. Grahame R, Bird HA, Child A. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 2000 27 : 1777 1779.
6. Drossman DA. Rome III : The Functional Gastrointestinal Disorders. 3rd edn. McLean, Va Degnon Associates, 2006.
7. Ofluoglu D, Gunduz OH, Kul-Panza E, Guven Z. Hypermobility in women with fibromyalgia syndrome. Clin Rheumatol 2006 25 : 291 293.
8. Chang L. The association of functional gastrointestinal disorders and fibromyalgia. Eur J Surg Suppl 1998 583 : 32 6.
9. Nijs J, Aerts A, De Meirleir K. Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy control subjects. J Manipulative Physiol Ther 2006 29 : 32 9.
10. Frissora CL, Koch KL. Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Current Gastroenterol Rep 2005 7 : 264 271.
11. North CS, Hong BA, Alpers DH. Relationship of functional gastrointestinal disorders and psychiatric disorders: implications for treatment. World J Gastroenterol 2007 13 : 2020 2027.
12. Gazit Y, Nahir AM, Grahame R, Jacob G. Dysautonomia in the joint hypermobility syndrome. Am J Med 2003 115 : 33 40.
13. Lacy BE. IBS and autonomic nervous system responses to pain. J Clin Gastroenterol 2006 40 : 767 768.
14. Martin-Santos R, Bulbena A, Porta M, Gago J, Molina L, Duro JC. Association between joint hypermobility syndrome and panic disorder. Am J Psychiatry 1998 155 : 1578 1583.
15. Lydiard RB. Increased prevalence of functional gastrointestinal disorders in panic disorder: clinical and theoretical implications. CNS Spectr 2005 10 : 899 908.
16. Cole JA, Rothman KJ, Cabral HJ, Zhang Y, Farraye FA. Migraine, fibromyalgia, and depression among people with IBS: a prevalence study. BMC Gastroenterol 2006 6 : 26.
17. Tobin MC, Moparty B, Farhadi A, Demeo MT, Bansal PJ, Keshavarzian A. Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Ann Allergy Asthma Immunol 2008 100 : 49 53.
18. Klemp P, Williams SM, Stansfield SA. Articular mobility in Maori and European New Zealanders. Rheumatology (Oxford) 2002 41 : 554 557.
19. Grahame R, Hakim AJ. Hypermobility. Current Opin Rheumatol 2008 20 : 106 110.
20. Hakim AJ, Cherkas LF, Grahame R, Spector TD, Macgregor AJ. The genetic epidemiology of joint hypermobility: a population study of female twins. Arthritis Rheum 2004 50 : 2640 2644.
21. Mccormack M, Briggs J, Hakim A, Grahame R. Joint laxity and the benign joint hypermobility syndrome in student and professional ballet dancers. J Rheumatol 2004 31 : 173 178.
22. Mikkelsson M, El-Metwally A, Kautiainen H, Auvinen A, Macfarlane GJ, Salminen JJ. Onset, prognosis and risk factors for widespread pain in schoolchildren: a prospective 4-year follow-up study. Pain 2008 138 : 681 687.
23. Seow CC, Chow PK, Khong KS. A study of joint mobility in a normal population. Ann Acad Med Singapore 1999 28 : 231 236.
24. Birrell FN, Adebajo AO, Hazleman BL, Silman AJ. High prevalence of joint laxity in West Africans. Br J Rheumatol 1994 33 : 56 9.
25. Remvig L, Jensen DV, Ward RC. Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol 2007 34 : 804 809. (Pubitemid 46641389)
26. Talley NJ. Functional gastrointestinal disorders as a public health problem. Neurogastroenterol Motil 2008 20 (Suppl. 1 121 129.
27. Riedl A, Schmidtmann M, Stengel A et al. Somatic comorbidities of irritable bowel syndrome: a systematic analysis. J Psychosom Res 2008 64 : 573 582.
28. Beighton P, Solomon L, Soskolne CL. Articular mobility in an African population. Ann Rheum Dis 1973 32 : 413 418.
29. Hakim AJ, Grahame R. A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract 2003 57 : 163 166.
30. Beighton P. Hypermobility scoring. Br J Rheumatol 1988 27 : 163.
31. Danquechin Dorval E, Barbieux JP, Picon L, Alison D, Codjovi P, Rouleau P. [Simplified measurement of colonic transit time by one radiography of the abdomen and a single type of marker. Normal values in 82 volunteers related to the sexes]. Gastroenterol Clin Biol 1994 18 : 141 144.
32. Abell TL, Camilleri M, Donohoe K et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am J Gastroenterol 2008 103 : 753 763.
33. Rikken-Bultman DG, Wellink L, Van Dongen PW. Hypermobility in two Dutch school populations. Eur J Obstet Gynecol Reprod Biol 1997 73 : 189 192.
34. Seckin U, Tur BS, Yilmaz O, Yagci I, Bodur H, Arasil T. The prevalence of joint hypermobility among high school students. Rheumatol Int 2005 25 : 260 263.
35. Chang L. Review article: epidemiology and quality of life in functional gastrointestinal disorders. Aliment Pharmacol Ther 2004 20 (Suppl. 7 31 9.
36. Soykan I, Sivri B, Sarosiek I, Kiernan B, Mccallum RW. Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis. Dig Dis Sci 1998 43 : 2398 2404.
37. Grundy D, Schemann M. Enteric nervous system. Current Opin Gastroenterol 2006 22 : 102 110.
38. Gregersen H, Liao D, Pedersen J, Drewes AM. A new method for evaluation of intestinal muscle contraction properties: studies in normal subjects and in patients with systemic sclerosis. Neurogastroenterol Motil 2007 19 : 11 9.
39. Meier-Ruge WA, Bruder E. Pathology of chronic constipation in pediatric and adult coloproctology. Pathobiology 2005 72 : 1 102.
40. Kellow JE, Azpiroz F, Delvaux M et al. Applied principles of neurogastroenterology: physiology/motility sensation. Gastroenterology 2006 130 : 1412 1420.
41. Van Der Veek PP, Steenvoorden M, Steens J, Van Der Schaar PJ, Brussee J, Masclee AA. Recto-colonic reflex is impaired in patients with irritable bowel syndrome. Neurogastroenterol Motil 2007 19 : 653 659.
42. Van Der Veek PP, Swenne CA, Vooren H, Schoneveld AL, Maestri R, Masclee AA. Viscerosensory-cardiovascular reflexes: altered baroreflex sensitivity in irritable bowel syndrome. Am J Physiol 2005 289 : R970 6.
43. Knowles CH, Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. Gut 2008 57 : 674 683.
44. Moshiree B, Zhou Q, Price DD, Verne GN. Central sensitisation in visceral pain disorders. Gut 2006 55 : 905 908.
45. Delvaux M. Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome. Gut 2002 51 (Suppl. 1 i67 71.
46. Reilly DJ, Chase JW, Hutson JM et al. Connective tissue disorder - a new subgroup of boys with slow transit constipation? J Pediatr Surg 2008 43 : 1111 1114.