Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 2, 2010, Pages 888-893

  Olsen, Randall J ^a   Sitkiewicz, Izabela ^a   Ayeras, Ara A ^a   Gonulal, Vedia E ^a   Cantu, Concepcion ^a   Beres, Stephen B ^a   Green, Nicole M ^a   Lei, Benfang ^b   Humbird, Tammy ^c   Greaver, Jamieson ^c   Chang, Ellen ^a   Ragasa, Willie P ^a   Montgomery, Charles A ^d   Cartwright Jr , Joiner ^e   McGeer, Allison ^f   Low, Donald E ^g   Whitney, Adeline R ^h   Cagle, Philip T ^a   Blasdel, Terry L ^c   DeLeo, Frank R ^h   Musser, James M ^a   more..

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF HOUSTON   (United States)

^d ComPath ^*  (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f MOUNT SINAI HOSPITAL   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

^h NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Group A streptococcus; Invasive infection; Molecular epidemiology of strain genotype patient phenotype relationships; Nonhuman primate

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENOME; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; FEMALE; GENE MUTATION; GROUP A STREPTOCOCCAL INFECTION; MACACA; MICROARRAY ANALYSIS; MOUSE; NECROTIZING FASCIITIS; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; FASCIITIS, NECROTIZING; GENETIC VARIATION; HUMANS; MACACA FASCICULARIS; MALE; MICE; NEUTROPHILS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEROTYPING; SHOCK, SEPTIC; STREPTOCOCCUS PYOGENES; UP-REGULATION; VIRULENCE;

BACTERIA (MICROORGANISMS); MUS; PRIMATES; STREPTOCOCCUS SP. 'GROUP A';

EID: 76249128672     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911811107     Document Type: Article

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