Cancer research on non-small cell lung cancer in smokers and non-smokers: Snapshots from the AACR annual meeting 2009

Cancer Biology and Therapy

Volumn 8, Issue 14, 2009, Pages 1309-1312

  Cho, William C S ^a  

^a QUEEN ELIZABETH HOSPITAL   (Hong Kong)

Author keywords

AACR annual meeting report; American Association for Cancer Research (AACR); EGFR tyrosine kinase inhibitor (TKI); Epidermal growth factor receptor (EGFR); Genome wide association study (GWAS); Non small cell lung cancer (NSCLC); Non smokers; Smokers

Indexed keywords

ADH 1; ANTINEOPLASTIC AGENT; BIBW 2992; CETUXIMAB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR; GEFITINIB; MICRORNA; PEMETREXED; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; VANDETANIB; EGFR PROTEIN, HUMAN; NEW DRUG; TUMOR PROTEIN;

ADVANCED CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER INCIDENCE; CANCER RESEARCH; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHRNA3 GENE; CHRNA5 GENE; CHRNB4 GENE; CHROMOSOME 15Q; CIGARETTE SMOKING; CLINICAL TRIAL; CONFERENCE PAPER; DRUG ANTAGONISM; ETHNIC DIFFERENCE; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MEDICAL SOCIETY; MOLECULAR BIOLOGY; MONOTHERAPY; NONHUMAN; OXIDATIVE STRESS; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; FEMALE; GENETICS; LUNG TUMOR; MALE; PHYSIOLOGY; RESEARCH; RISK; SMOKING; TUMOR GENE;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; DRUGS, INVESTIGATIONAL; FEMALE; GENES, NEOPLASM; HUMANS; LUNG NEOPLASMS; MALE; NEOPLASM PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESEARCH; RISK; SMOKING;

EID: 76249128598     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.14.9195     Document Type: Conference Paper

References (27)

1. Au JS, Cho WC, Yip TT, Law SC. Proteomic approach to biomarker discovery in cancer tissue from lung adenocarcinoma among nonsmoking Chinese women in Hong Kong. Cancer Invest 2008; 26:128-35.
2. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008; 452:633-7.
3. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008; 452:638-42.
4. Cho WC. A future of cancer prevention and cures: highlights of the Centennial Meeting of the American Association for Cancer Research. Ann Oncol 2008; 19:205-11.
5. Cho WC. Latest discoveries and trends in translational cancer research: highlights of the 2008 Annual Meeting of the American Association for Cancer Research. Technol Cancer Res Treat 2008; 7:269-77.
6. Amos CI, Wu XF, Wei CJ, Frazier M, Mills G, Spitz MS. Variation in nicotinic acetylcholine receptor genes CHRNA3 and CHRNA5 influences both smoking behavior and lung cancer risk: characterization of risk in multiethnic populations. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
7. Schwartz AG, Wenzlaff AS, Cote ML, Dyke AV, Bock C, Ruterbusch J, et al. Lung cancer, smoking and genetic susceptibility in African Americans. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
8. Brennan PJ, Lips EH, McKay J, Boffetta P, Hashibe M, Heath S, et al. Post genome-wide association research: lessons from lung cancer studies. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
9. Spitz MR, Amos CI, D'Amelio AM, Dong Q, Etzel C. Molecular epidemiology of lung cancer in never smokers. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
10. Li YJ, Chen CF, Yang SY, Liao KM, Chen CJ. Polymorphisms of estrogen-related genes and risk of female lung adenocarcinoma in Taiwan. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
11. Yang SY, Chen CF, Li YJ, Liao KM, Chen CJ. Glutathione S-transferase P1 gene polymorphism and the risk of female lung adenocarcinoma. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
12. Goldkorn T, Khan E. EGF receptor exposed to cigarette smoke undergoes aberrant activation and trafficking. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
13. Chmielecki J, Foo J, Somwar R, Regales L, Vivanco I, Shen RL, et al. EGFR T790M decreases growth potential of lung tumor cells with drug-sensitive EGFR mutant alleles in the absence of drug selection. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
14. Herynk MH, Cascone T, Xu L, Heymach JV. A role for c-Src in EGFR-induced upregulation of HIF-1α. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
15. Gao M, Yeh PY, Lu YS, Lin HM, Cheng AL. EGFR variant 4 complexes with NFκB p50 to upregulate VEGF receptor 2 expression in lung cancer cells. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
16. Dulak AM, Siegfried JM. The Src family kinases mediate EGFR-induced prolonged c-Met phosphorylation in non-small cell lung cancer. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
17. Ware KE, Heasley LE, Marek L, Marshall ME, Hercule P. Identification of transcriptional target pathways of FGFR and EGFR in NSCLC. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
18. Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005; 97:339-46.
19. Cho WC. OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 2007; 6:60.
20. Cho WC, Chow AS, Au JS. Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer 2009; doi:10.1016/j.ejca.2009,01.039.
21. Chan DC, Gupta M, Zheng D, Zhang ZY, Sui XM, Peters WP, et al. Superior antitumor activity of ADH-1 in vivo compared to erlotinib (Tarceva) in lung cancer cell lines. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
22. Luo J, Peet CR, Bertics PJ. Examination of mutant EGF receptors linked to non-small cell lung cancer and their responses to gefitinib. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
23. Regales L, Gong YX, Politi K, Shen RL, Spassova M, Ouerfelli O, et al. EGFR T790M-driven murine lung tumors respond to dual EGFR targeting with cetuximab and BIBW-2992. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
24. Ichihara E, Ohashi K, Takigawa N, Osawa M, Takeda H, Ochi N, et al. Effects of vandetanib on lung adenocarcinoma cells harboring an EGFR T790M mutation in vivo. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
25. Kubo T, Ohashi K, Osawa M, Takeda H, Ichihara E, Fujii M, et al. Chemopreventive effect of vandetanib on tumorigenesis in a mouse model of non-smoking related lung cancer. In: American Association for Cancer Research Annual Meeting: Proceedings, 2009 Apr 18-22, Denver CO. Philadelphia, PA: AACR 2009.
26. Cho WC. Potentially useful biomarkers for the diagnosis, treatment and prognosis of lung cancer. Biomed Pharmacother 2007; 61:515-9.
27. Cho WC. Updates in cancer research: insights from the AACR 100th Annual Meeting. Expert Rev Mol Diagn 2009; in press.