Ultrasonographic prediction of homozygous α 0-thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: Alone or in combination?

Ultrasound in Obstetrics and Gynecology

Volumn 35, Issue 2, 2010, Pages 149-154

  Leung, K Y ^a   Cheong, K B ^a   Lee, C P ^a   Chan, V ^a   Lam, Y H ^b   Tang, M ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b TSAN YUK HOSPITAL   (Hong Kong)

Author keywords

Thalassemia; Cardiomegaly; Doppler; Middle cerebral artery; Placenta; Prenatal ultrasonography

Indexed keywords

ALPHA THALASSEMIA; ARTICLE; BLOOD FLOW VELOCITY; CARDIOMEGALY; COMPARATIVE STUDY; ECHOGRAPHY; FEMALE; FETUS ECHOGRAPHY; GENETICS; GESTATIONAL AGE; HOMOZYGOTE; HUMAN; METHODOLOGY; MIDDLE CEREBRAL ARTERY; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; PREDICTION AND FORECASTING; PREGNANCY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; THORACIC AORTA;

ALPHA-THALASSEMIA; AORTA, THORACIC; BLOOD FLOW VELOCITY; CARDIOMEGALY; FEMALE; GESTATIONAL AGE; HOMOZYGOTE; HUMANS; MIDDLE CEREBRAL ARTERY; PLACENTA; PREDICTIVE VALUE OF TESTS; PREGNANCY; RISK FACTORS; SENSITIVITY AND SPECIFICITY; ULTRASONOGRAPHY, PRENATAL;

EID: 76249125841     PISSN: 09607692     EISSN: 14690705     Source Type: Journal    
DOI: 10.1002/uog.7443     Document Type: Article

References (17)

1. Todd D, Lai MCS, Braga CA. Thalassemia and hydrops fetalis - family studies. BMJ 1967; 3: 347-352.
2. Weatherall DJ, Clegg JB, Wong HB. The hemoglobin constitution of infants with hemoglobin Bart's hydrops fetalis syndrome. Br J Haematol 1970; 18: 357-367.
3. Liang ST, Wong V, So WK, Ma HK, Chan V, Todd D. Homozygous a-thalassemia: clinical presentation, diagnosis and management. A review of 46 cases. Br J Obstet Gynaecol 1985; 92: 680-684.
4. Singer ST, Styles L, Bojanowski J, Quirolo K, Foote D, Vichinsky EP. Changing outcome of homozygous alpha-thalassemia: cautious optimism. J Pediatr Hematol Oncol 2000; 22: 539-542.
5. Ghosh A, Tang MHY, Lam YH, Fung E, Chan V. Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous a-thalassemia-1. Lancet 1994; 344: 988-989.
6. Lam YH, Ghosh A, Tang MHY, Lee CP, Sin SY. Early ultrasound prediction of pregnancies affected by homozygous athalassemia-1. Prenat Diagn 1997; 17: 327-332.
7. Lam YH, Tang MHY, Lee CP, Tse HY. Prenatal ultrasonographic prediction of homozygous type 1 alpha-thalassemia at 12-13 weeks of gestation. Am J Obstet Gynecol 1999; 180: 148-150.
8. Tongsong T, Wanapirak C, Sirichotiyakul S. Placental thickness at midpregnancy as a predictor of Hb Bart's Disease. Prenat Diagn 1999; 19: 1027-1030.
9. Tongsong T, Wanapirak C, Sirchotiyakul S, Piyamongkol W, Chanprapaph P. Fetal sonographic cardiothoracic ratio at midpregnancy as a predictor of Hb Bart disease. J Ultrasound Med 1999; 18: 807-811.
10. Tongsong T, Wanapirak C, Sirchotiyakul S, Chanprapaph P. Sonographic markers of hemoglobin Bart disease at midpregnancy. J Ultrasound Med 2004; 23: 49-55.
11. Leung KY, Liao C, Li QM, Ma SY, Tang MHY, Lee CP, Chan V, Lam YH. A new strategy for prenatal diagnosis of homozygous alpha-thalassaemia. Ultrasound Obstet Gynecol 2006; 28: 173-177.
12. Mari G, Deter RL, Carpenter RL, Rahman F, Zimmerman R, Moise KJ Jr, Dorman KF, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel JA, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell SC. Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. N Engl J Med 2000; 342: 9-14.
13. Leung WC, Oepkes D, Seaward G, Ryan G. Serial sonographic findings of four fetuses with homozygous alpha-thalassemia-1 from 21 weeks onwards. Ultrasound Obstet Gynecol 2002; 19: 56-59.
14. Leung KY, Lee CP, Tang MHY, Chan HY, Chan V. Prenatal diagnosis of alpha-thalassaemia in a twin pregnancy. Ultrasound Obstet Gynecol 2005; 25: 201-202.
15. Hanif F, Drennan K, Mari G. Variables that affect the middle cerebral artery peak systolic velocity in fetuses with anemia and intrauterine growth restriction. Am J Perinatol 2007; 24: 501-505.
16. Lam YH, Tang MH. Middle cerebral artery Doppler study in fetuses with homozygous alpha-thalassaemia-1 at 12-13 weeks of gestation. Prenat Diagn 2002; 22: 56-58. 17.
17. Chui DH, Waye JS. Hydrops fetalis caused by alphathalassemia: an emerging health care problem. Blood 1998; 91: 2213-2222.