Mapping of quantitative trait loci affecting classical scrapie incubation time in a population comprising several generations of scrapie-infected sheep

Journal of General Virology

Volumn 91, Issue 2, 2010, Pages 575-579

  Moreno, Carole R ^a   Moazami Goudarzi, Katayoun ^b   Briand, Stephanie ^a   Robert Granié, Christèle ^a   Weisbecker, Jean Louis ^c   Laurent, Pascal ^b   Cribiu, Edmond Paul ^b   Haley, Christopher S ^d   Andréoletti, Olivier ^e   Bishop, Stephen C ^d   Pong Wong, Ricardo ^d  

^a CEMAGREF   (France)

^b UMR1313 GÉNÉTIQUE ANIMALE ET BIOLOGIE INTÉGRATIVE   (France)

^c Domaine Expérimental de Langlade   (France)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e IHAP   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 18; CHROMOSOME 6; CONTROLLED STUDY; FEMALE; GENOTYPE; INCUBATION TIME; INFECTION SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; SCRAPIE; SHEEP; ANIMAL; CHROMOSOME MAP; GENETIC PREDISPOSITION; GENETICS; PATHOLOGY; PEDIGREE; QUANTITATIVE TRAIT LOCUS; TIME;

OVIS ARIES;

ANIMALS; CHROMOSOME MAPPING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; MALE; PEDIGREE; PRPC PROTEINS; QUANTITATIVE TRAIT LOCI; SCRAPIE; SHEEP; TIME FACTORS;

EID: 76249104452     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.014134-0     Document Type: Article

References (42)

1. Sc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol 81, 3115-3126.
2. Andréoletti, O., Berthon, P., Levavasseur, E., Marc, D., Lantier, F., Monks, E., Elsen, J. M. & Schelcher, F. (2002a). Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry. J Histochem Cytochem 50, 1357-1370.
3. Sc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol 83, 2607-2616.
4. Carrell, R. W. & Gooptu, B. (1998). Conformational changes and disease - serpins, prions and Alzheimer's. Curr Opin Struct Biol 8, 799-809.
5. Ciesielski-Treska, J., Ulrich, G., Taupenot, L., Chasserot-Golaz, S., Corti, A., Aunis, D. & Bader, M. F. (1998). Chromogranin A induces a neurotoxic phenotype in brain microglial cells. J Biol Chem 273, 14339-14346.
6. Diaz, C., Vitezica, Z. G., Rupp, R., Andréoletti, O. & Elsen, J. M. (2005). Polygenic variation and transmission factors involved in the resistance/susceptibility to scrapie in a Romanov flock. J Gen Virol 86, 849-857.
7. Elsen, J. M., Amigues, Y., Schelcher, F., Ducrocq, V., Andreoletti, O., Eychenne, F., Khang, J. V., Poivey, J. P., Lantier, F. & Laplanche, J. L. (1999). Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch Virol 144, 431-445.
8. Evans, C. G., Wisen, S. & Gestwicki, J. E. (2006). Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. J Biol Chem 281, 33182-33191.
9. Faller, E. M. & Brown, D. L. (2009). Modulation of microtubule dynamics by the microtubule-associated protein 1a. J Neurosci Res 87, 1080-1089.
10. Fraser, H., Bruce, M. & McConnell, I. (1991). Murine scrapie strains, BSE models and genetics. In Sub-Acute Spongiform Encephalopathies, pp. 131-136. Edited by R. Bradley, M. Savey & B. Marchant: Commission of European Communities. The Netherlands: Kluwer Academic.
11. George, A. W., Visscher, P. M. & Haley, C. S. (2000). Mapping quantitative trait loci in complex pedigrees: a two-step variance component approach. Genetics 156, 2081-2092.
12. Gilmour, A., Gogel, B., Cullis, B., Welham, S. & Thompson, R. (2002). ASReml User Guide Release 1.0, p. 267. Hemel Hempstead, UK: VSN International Ltd.
13. Goldmann, W., Hunter, N., Foster, J. D., Salbaum, J. M., Beyreuther, K. & Hope, J. (1990). Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A 87, 2476-2480.
14. Goldmann, W., Hunter, N., Smith, G., Foster, J. & Hope, J. (1994). PrP genotypes and the Sip gene in Cheviot sheep form the basis for scrapie strain typing in sheep. Ann N Y Acad Sci 724, 296-299.
15. Gooptu, B. & Lomas, D. A. (2009). Conformational pathology of the serpins: themes, variations, and therapeutic strategies. Annu Rev Biochem 78, 147-176.
16. Hernandez-Sanchez, J., Waddington, D., Wiener, P., Haley, C. S. & Williams, J. L. (2002). Genome-wide search for markers associated with bovine spongiform encephalopathy. Mamm Genome 13, 164-168.
17. Hooper, C. & Pocock, J. M. (2007). Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia. Neurosci Lett 413, 227-232.
18. Houston, E. F., Halliday, S. I., Jeffrey, M., Goldmann, W. & Hunter, N. (2002). New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1). J Gen Virol 83, 1247-1250.
19. Ihara, N., Takasuga, A., Mizoshita, K., Takeda, H., Sugimoto, M., Mizoguchi, Y., Hirano, T., Itoh, T., Watanabe, T. & Reed, K. M. (2004). A Comprehensive Genetic Map of the Cattle Genome Based on 3802 Microsatellites, pp. 1987-1998. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
20. Jeffrey, M. & Gonzalez, L. (2004). Pathology and pathogenesis of bovine spongiform encephalopathy and scrapie. Curr Top Microbiol Immunol 284, 65-97.
21. Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke-Haerter, P. J. & other authors (2002). Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. FASEB J 16, 601-603.
22. Lander, E. S. & Botstein, D. (1989). Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199.
23. Lauren, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W. & Strittmatter, S. M. (2009). Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers. Nature 457, 1128-1132.
24. Laurent, P., Schibler, L., Vaiman, A., Laubier, J., Delcros, C., Cosseddu, G., Vaiman, D., Cribiu, E. P. & Yerle, M. (2007). A 12000-rad whole-genome radiation hybrid panel in sheep: application to the study of the ovine chromosome 18 region containing a QTL for scrapie susceptibility. Anim Genet 38, 358.
25. Lloyd, S. E., Onwuazor, O. N., Beck, J. A., Mallinson, G., Farrall, M., Targonski, P., Collinge, J. & Fisher, E. M. (2001). Identification of multiple quantitative trait loci linked to prion disease incubation period in mice. Proc Natl Acad Sci U S A 98, 6279-6283.
26. Lloyd, S. E., Uphill, J. B., Targonski, P. V., Fisher, E. M. & Collinge, J. (2002). Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice. Neurogenetics 4, 77-81.
27. Lomas, D. A. & Carrell, R. W. (2002). Serpinopathies and the conformational dementias. Nat Rev Genet 3, 759-768.
28. Manolakou, K., Beaton, J., McConnell, I., Farquar, C., Manson, J., Hastie, N. D., Bruce, M. & Jackson, I. J. (2001). Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice. Proc Natl Acad Sci U S A 98, 7402-7407.
29. Marcos-Carcavilla, A., Calvo, J. H., Gonzalez, C., Moazami-Goudarzi, K., Laurent, P., Bertaud, M., Hayes, H., Beattie, A. E., Serrano, C. & other authors (2008). Structural and functional analysis of the HSP90AA1 gene: distribution of polymorphisms among sheep with different responses to scrapie. Cell Stress Chaperones 13, 19-29.
30. Miele, G., Seeger, H., Marino, D., Eberhard, R., Heikenwalder, M., Stoeck, K., Basagni, M., Knight, R., Green, A. & other authors (2008). Urinary alpha1-antichymotrypsin: a biomarker of prion infection. PLoS One 3, e3870.
31. Miller, J. A., Oldham, M. C. & Geschwind, D. H. (2008). A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci 28, 1410-1420.
32. Moreno, C. R., Lantier, F., Lantier, I., Sarradin, P. & Elsen, J. M. (2003). Detection of new quantitative trait loci for susceptibility to transmissible spongiform encephalopathies in mice. Genetics 165, 2085-2091.
33. Moreno, C. R., Cosseddu, G. M., Schibler, L., Roig, A., Moazami-Goudarzi, K., Andréoletti, O., Eychenne, F., Lajous, D., Schelcher, F. & other authors (2008). Identification of new quantitative trait loci (other than the PRNP gene) modulating the scrapie incubation period in sheep. Genetics 179, 723-726.
34. Palmer, M. S., Dryden, A. J., Hughes, J. T. & Collinge, J. (1991). Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease. Nature 352, 340-342.
35. Pong Wong, R., George, A. W., Woolliams, J. A. & Haley, C. S. (2001). A simple and rapid method for calculating identity by descent matrices using multiple markers. Genet Sel Evol 33, 453-471.
36. Sanchez, M., De Givry, S. & Schiex, T. (2008). Mendelian error detection in complex pedigrees using weighted constraint satisfaction techniques. Constraints 13, 130-154.
37. SAS Institute (1990). SAS/STAT User's Guide, 4 edn. Cary, NC: SAS Institute.
38. Schibler, L., Roig, A., Mahe, M. F., Laurent, P., Hayes, H., Rodolphe, F. & Cribiu, E. P. (2006). High-resolution comparative mapping among man, cattle and mouse suggests a role for repeat sequences in mammalian genome evolution. BMC Genomics 7, 194.
39. Self, S. & Liang, K. (1987). Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82, 605-610.
40. Stephenson, D. A., Chiotti, K., Ebeling, C., Groth, D., DeArmond, S. J., Prusiner, S. B. & Carlson, G. A. (2000). Quantitative trait loci affecting prion incubation time in mice. Genomics 69, 47-53.
41. van Keulen, L. J., Vromans, M. E., Dolstra, C. H., Bossers, A. & van Zijderveld, F. G. (2007). Pathogenesis of bovine spongiform encephalopathy in sheep. Arch Virol 153, 445-453.
42. Zhang, C., De Koning, D. J., Hernandez-Sanchez, J., Haley, C. S., Williams, J. L. & Wiener, P. (2004). Mapping of multiple quantitative trait loci affecting bovine spongiform encephalopathy. Genetics 167, 1863-1872.