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Volumn 70, Issue 3, 2010, Pages 1101-1110

Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTANE; DEATH RECEPTOR 5; PROTEIN P53; RESVERATROL;

EID: 76249094425     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2889     Document Type: Article
Times cited : (95)

References (48)
  • 1
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)
    • Ashkenazi A, Holland P, Eckhardt SG. Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). J Clin Oncol 2008;26:3621-30.
    • (2008) J Clin Oncol , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 3
    • 0030880548 scopus 로고    scopus 로고
    • TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL
    • Walczak H, Degli-Esposti MA, Johnson RS, et al. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J 1997;16:5386-97.
    • (1997) EMBO J , vol.16 , pp. 5386-5397
    • Walczak, H.1    Degli-Esposti, M.A.2    Johnson, R.S.3
  • 4
    • 62449166171 scopus 로고    scopus 로고
    • Newsom-Davis T, Prieske S, Walczak H. Is TRAIL the holy grail of cancer therapy? Apoptosis 2009;14:607-23.
    • Newsom-Davis T, Prieske S, Walczak H. Is TRAIL the holy grail of cancer therapy? Apoptosis 2009;14:607-23.
  • 7
    • 58149116500 scopus 로고    scopus 로고
    • TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death
    • Kuribayashi K, Krigsfeld G, Wang W, et al. TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther 2008;7:2034-8.
    • (2008) Cancer Biol Ther , vol.7 , pp. 2034-2038
    • Kuribayashi, K.1    Krigsfeld, G.2    Wang, W.3
  • 9
    • 76249114175 scopus 로고    scopus 로고
    • In: Litwack G, editor. TRAIL. Academic Press; 2004.
    • In: Litwack G, editor. TRAIL. Academic Press; 2004.
  • 10
    • 0035911242 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon γ-dependent natural killer cell protection from tumor metastasis
    • Smyth MJ, Cretney E, Takeda K, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon γ-dependent natural killer cell protection from tumor metastasis. J Exp Med 2001;193:661-70.
    • (2001) J Exp Med , vol.193 , pp. 661-670
    • Smyth, M.J.1    Cretney, E.2    Takeda, K.3
  • 11
    • 0036467427 scopus 로고    scopus 로고
    • Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    • Cretney E, Takeda K, Yagita H, Glaccum M, Peschon JJ, Smyth MJ. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 2002;168:1356-61.
    • (2002) J Immunol , vol.168 , pp. 1356-1361
    • Cretney, E.1    Takeda, K.2    Yagita, H.3    Glaccum, M.4    Peschon, J.J.5    Smyth, M.J.6
  • 12
    • 0035137696 scopus 로고    scopus 로고
    • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    • Takeda K, Hayakawa Y, Smyth MJ, et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 2001;7:94-100.
    • (2001) Nat Med , vol.7 , pp. 94-100
    • Takeda, K.1    Hayakawa, Y.2    Smyth, M.J.3
  • 13
    • 0037148518 scopus 로고    scopus 로고
    • Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    • Takeda K, Smyth MJ, Cretney E, et al. Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med 2002;195:161-9.
    • (2002) J Exp Med , vol.195 , pp. 161-169
    • Takeda, K.1    Smyth, M.J.2    Cretney, E.3
  • 14
    • 10744220151 scopus 로고    scopus 로고
    • Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    • Takeda K, Yamaguchi N, Akiba H, et al. Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med 2004;199:437-48.
    • (2004) J Exp Med , vol.199 , pp. 437-448
    • Takeda, K.1    Yamaguchi, N.2    Akiba, H.3
  • 15
    • 34547628869 scopus 로고    scopus 로고
    • Combined natural killer T-cell based immunotherapy eradicates established tumors in mice
    • Teng MW, Westwood JA, Darcy PK, et al. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Cancer Res 2007;67:7495-504.
    • (2007) Cancer Res , vol.67 , pp. 7495-7504
    • Teng, M.W.1    Westwood, J.A.2    Darcy, P.K.3
  • 16
    • 27144489394 scopus 로고    scopus 로고
    • Cutting edge: TRAIL deficiency accelerates hematological malignancies
    • Zerafa N, Westwood JA, Cretney E, et al. Cutting edge: TRAIL deficiency accelerates hematological malignancies. J Immunol 2005;175:5586-90.
    • (2005) J Immunol , vol.175 , pp. 5586-5590
    • Zerafa, N.1    Westwood, J.A.2    Cretney, E.3
  • 17
    • 25444495618 scopus 로고    scopus 로고
    • Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor
    • Altucci L, Rossin A, Hirsch O, et al. Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor. Cancer Res 2005;65:8754-65.
    • (2005) Cancer Res , vol.65 , pp. 8754-8765
    • Altucci, L.1    Rossin, A.2    Hirsch, O.3
  • 18
    • 0034961181 scopus 로고    scopus 로고
    • Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL
    • Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H. Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. Nat Med 2001;7:680-6.
    • (2001) Nat Med , vol.7 , pp. 680-686
    • Altucci, L.1    Rossin, A.2    Raffelsberger, W.3    Reitmair, A.4    Chomienne, C.5    Gronemeyer, H.6
  • 19
    • 4143116932 scopus 로고    scopus 로고
    • Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL
    • Clarke N, Jimenez-Lara AM, Voltz E, Gronemeyer H. Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL. EMBO J 2004;23:3051-60.
    • (2004) EMBO J , vol.23 , pp. 3051-3060
    • Clarke, N.1    Jimenez-Lara, A.M.2    Voltz, E.3    Gronemeyer, H.4
  • 20
    • 13444306459 scopus 로고    scopus 로고
    • Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
    • Nebbioso A, Clarke N, Voltz E, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 2005;11:77-84.
    • (2005) Nat Med , vol.11 , pp. 77-84
    • Nebbioso, A.1    Clarke, N.2    Voltz, E.3
  • 21
    • 13444274622 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    • Insinga A, Monestiroli S, Ronzoni S, et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 2005;11:71-6.
    • (2005) Nat Med , vol.11 , pp. 71-76
    • Insinga, A.1    Monestiroli, S.2    Ronzoni, S.3
  • 22
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999;5:157-63.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3
  • 23
    • 0035437171 scopus 로고    scopus 로고
    • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
    • Mitsiades CS, Treon SP, Mitsiades N, et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood 2001;98:795-804.
    • (2001) Blood , vol.98 , pp. 795-804
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3
  • 24
    • 0037108712 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice
    • Naka T, Sugamura K, Hylander BL, Widmer MB, Rustum YM, Repasky EA. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res 2002;62:5800-6.
    • (2002) Cancer Res , vol.62 , pp. 5800-5806
    • Naka, T.1    Sugamura, K.2    Hylander, B.L.3    Widmer, M.B.4    Rustum, Y.M.5    Repasky, E.A.6
  • 25
    • 24944458177 scopus 로고    scopus 로고
    • Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: Induction of apoptosis and enhancement of doxorubicin- and bortezomibinduced cell death
    • Georgakis GV, Li Y, Humphreys R, et al. Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomibinduced cell death. Br J Haematol 2005;130:501-10.
    • (2005) Br J Haematol , vol.130 , pp. 501-510
    • Georgakis, G.V.1    Li, Y.2    Humphreys, R.3
  • 26
    • 20244378961 scopus 로고    scopus 로고
    • Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2
    • Motoki K, Mori E, Matsumoto A, et al. Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2. Clin Cancer Res 2005;11:3126-35.
    • (2005) Clin Cancer Res , vol.11 , pp. 3126-3135
    • Motoki, K.1    Mori, E.2    Matsumoto, A.3
  • 27
    • 21044441651 scopus 로고    scopus 로고
    • HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
    • Pukac L, Kanakaraj P, Humphreys R, et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br J Cancer 2005;92:1430-41.
    • (2005) Br J Cancer , vol.92 , pp. 1430-1441
    • Pukac, L.1    Kanakaraj, P.2    Humphreys, R.3
  • 28
    • 38149122326 scopus 로고    scopus 로고
    • TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
    • Grosse-Wilde A, Voloshanenko O, Bailey SL, et al. TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest 2008;118:100-10.
    • (2008) J Clin Invest , vol.118 , pp. 100-110
    • Grosse-Wilde, A.1    Voloshanenko, O.2    Bailey, S.L.3
  • 29
    • 45749098451 scopus 로고    scopus 로고
    • To kill a tumor cell: The potential of proapoptotic receptor agonists
    • Ashkenazi A, Herbst RS. To kill a tumor cell: the potential of proapoptotic receptor agonists. J Clin Invest 2008;118:1979-90.
    • (2008) J Clin Invest , vol.118 , pp. 1979-1990
    • Ashkenazi, A.1    Herbst, R.S.2
  • 30
    • 66349130221 scopus 로고    scopus 로고
    • Discovery and optimization of a TRAIL R2 agonist for cancer therapy
    • Angell YM, Bhandari A, De Francisco MN, et al. Discovery and optimization of a TRAIL R2 agonist for cancer therapy. Adv Exp Med Biol 2009;611:101-3.
    • (2009) Adv Exp Med Biol , vol.611 , pp. 101-103
    • Angell, Y.M.1    Bhandari, A.2    De Francisco, M.N.3
  • 31
    • 33746694185 scopus 로고    scopus 로고
    • Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists
    • Li B, Russell SJ, Compaan DM, et al. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. J Mol Biol 2006;361:522-36.
    • (2006) J Mol Biol , vol.361 , pp. 522-536
    • Li, B.1    Russell, S.J.2    Compaan, D.M.3
  • 32
    • 60549106191 scopus 로고    scopus 로고
    • The Fas-FADD death domain complex structure unravels signalling by receptor clustering
    • Scott FL, Stec B, Pop C, et al. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 2009;457:1019-22.
    • (2009) Nature , vol.457 , pp. 1019-1022
    • Scott, F.L.1    Stec, B.2    Pop, C.3
  • 33
    • 36248942022 scopus 로고    scopus 로고
    • Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L
    • Berg D, Lehne M, Muller N, et al. Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death Differ 2007;14:2021-34.
    • (2007) Cell Death Differ , vol.14 , pp. 2021-2034
    • Berg, D.1    Lehne, M.2    Muller, N.3
  • 34
    • 34548713016 scopus 로고    scopus 로고
    • LY303511 amplifies TRAILinduced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization
    • Poh TW, Huang S, Hirpara JL, Pervaiz S. LY303511 amplifies TRAILinduced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. Cell Death Differ 2007;14:1813-25.
    • (2007) Cell Death Differ , vol.14 , pp. 1813-1825
    • Poh, T.W.1    Huang, S.2    Hirpara, J.L.3    Pervaiz, S.4
  • 35
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat Rev Cancer 2002;2:331-41.
    • (2002) Nat Rev Cancer , vol.2 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 36
    • 45949123116 scopus 로고
    • Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin
    • Rink H. Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin. Tetrahedron Lett 1987;28:3787-90.
    • (1987) Tetrahedron Lett , vol.28 , pp. 3787-3790
    • Rink, H.1
  • 37
    • 49549139072 scopus 로고    scopus 로고
    • Castro B, Dormoy JR, Evin G, Selve C. Reactifs de couplage peptidique I (1) - l'hexafluorophosphate de benzotriazolyl N-oxytrisdimethylamino phosphonium (B.O.P.). Tetrahedron Lett 1975;16:1219-22.
    • Castro B, Dormoy JR, Evin G, Selve C. Reactifs de couplage peptidique I (1) - l'hexafluorophosphate de benzotriazolyl N-oxytrisdimethylamino phosphonium (B.O.P.). Tetrahedron Lett 1975;16:1219-22.
  • 38
    • 60549097550 scopus 로고    scopus 로고
    • Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting
    • Humblet V, Misra P, Bhushan KR, et al. Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting. J Med Chem 2009;52:544-50.
    • (2009) J Med Chem , vol.52 , pp. 544-550
    • Humblet, V.1    Misra, P.2    Bhushan, K.R.3
  • 39
    • 0032550366 scopus 로고    scopus 로고
    • Conversion of membranebound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
    • Schneider P, Holler N, Bodmer JL, et al. Conversion of membranebound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med 1998;187:1205-13.
    • (1998) J Exp Med , vol.187 , pp. 1205-1213
    • Schneider, P.1    Holler, N.2    Bodmer, J.L.3
  • 40
    • 10644296258 scopus 로고    scopus 로고
    • The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation
    • Thomas LR, Johnson RL, Reed JC, Thorburn A. The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation. J Biol Chem 2004;279:52479-86.
    • (2004) J Biol Chem , vol.279 , pp. 52479-52486
    • Thomas, L.R.1    Johnson, R.L.2    Reed, J.C.3    Thorburn, A.4
  • 41
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003;114:181-90.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 43
    • 33646068410 scopus 로고    scopus 로고
    • Resveratrol as a chemopreventive agent: A promising molecule for fighting cancer
    • Delmas D, Lancon A, Colin D, Jannin B, Latruffe N. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 2006;7:423-42.
    • (2006) Curr Drug Targets , vol.7 , pp. 423-442
    • Delmas, D.1    Lancon, A.2    Colin, D.3    Jannin, B.4    Latruffe, N.5
  • 44
    • 35748944093 scopus 로고    scopus 로고
    • A new era of cancer therapy: Cancer cell targeted therapies are coming of age
    • Voltz E, Gronemeyer H. A new era of cancer therapy: cancer cell targeted therapies are coming of age. Int J Biochem Cell Biol 2008;40:1-8.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1-8
    • Voltz, E.1    Gronemeyer, H.2
  • 45
    • 33845190564 scopus 로고    scopus 로고
    • Cancer: Novel therapeutic strategies that exploit the TNF-related apoptosis-inducing ligand (TRAIL)/ TRAIL receptor pathway
    • Cretney E, Takeda K, Smyth MJ. Cancer: novel therapeutic strategies that exploit the TNF-related apoptosis-inducing ligand (TRAIL)/ TRAIL receptor pathway. Int J Biochem Cell Biol 2007;39:280-6.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 280-286
    • Cretney, E.1    Takeda, K.2    Smyth, M.J.3
  • 46
    • 45849115453 scopus 로고    scopus 로고
    • TRAIL death receptors as tumor suppressors and drug targets
    • Finnberg N, El-Deiry WS. TRAIL death receptors as tumor suppressors and drug targets. Cell Cycle 2008;7:1525-8.
    • (2008) Cell Cycle , vol.7 , pp. 1525-1528
    • Finnberg, N.1    El-Deiry, W.S.2
  • 47
    • 16644372319 scopus 로고    scopus 로고
    • Following a TRAIL: Update on a ligand and its five receptors
    • Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors. Cell Res 2004;14:359-72.
    • (2004) Cell Res , vol.14 , pp. 359-372
    • Kimberley, F.C.1    Screaton, G.R.2
  • 48
    • 35948945062 scopus 로고    scopus 로고
    • Small multivalent architectures mimicking homotrimers of the TNF superfamily member CD40L: Delineating the relationship between structure and effector function
    • Trouche N, Wieckowski S, Sun W, et al. Small multivalent architectures mimicking homotrimers of the TNF superfamily member CD40L: delineating the relationship between structure and effector function. J Am Chem Soc 2007;129:13480-92.
    • (2007) J Am Chem Soc , vol.129 , pp. 13480-13492
    • Trouche, N.1    Wieckowski, S.2    Sun, W.3


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