Polymorphisms of the macrophage migration inhibitory factor gene in a UK population with Type 1 diabetes mellitus

Diabetic Medicine

Volumn 27, Issue 2, 2010, Pages 143-149

  Martin, R J L ^a   Savage, D A ^a   Carson, D J ^a   McKnight, A J ^a   Maxwell, A P ^a   Patterson, C C ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Haplotype; Macrophage migration inhibitory factor; Polymorphism; Type 1 diabetes mellitus

Indexed keywords

MACROPHAGE MIGRATION INHIBITION FACTOR; MICROSATELLITE DNA;

ADOLESCENT; ALLELE; ARTICLE; CASE CONTROL STUDY; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE COURSE; DISEASE PREDISPOSITION; DNA FLANKING REGION; EXON; FEMALE; FLUORESCENCE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SCREENING; GENOTYPE; HAPLOTYPE; HIGH RISK POPULATION; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTRON; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARENT; PEDIGREE ANALYSIS; PROGENY; PYROSEQUENCING; SEGREGATION DISTORTION; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; DNA SEQUENCE; FAMILY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS;

ADOLESCENT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GREAT BRITAIN; HAPLOTYPES; HUMANS; INTRONS; LINKAGE DISEQUILIBRIUM; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA;

EID: 76249087108     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2009.02916.x     Document Type: Article

References (30)

1. Atkinson MA, MacLaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994 331 : 1428 1436.
2. Pirot P, Cardozo AK, Eizirik DL. Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arq Bras Endrocrinol Metab 2008 52 : 156 165.
3. Imamura K, Nishihira J, Suzuki M, Yasuda K, Sasaki S, Kusunoki Y et al. Identification and immunohistochemical localization of macrophage migration inhibitory factor in human kidney. Biochem Mol Biol Int 1996 40 : 1233 1242. (Pubitemid 27032402)
4. Calandra T, Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 2003 3 : 791 800. (Pubitemid 37328657)
5. Calandra T, Bernhagen J, Metz CN, Spiegel M, Bacher T, Donnelly T et al. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995 377 : 68 71.
6. Toso C, Emamaullee JA, Merani S, Shapiro AMJ. The role of macrophage migration inhibitory factor on glucose metabolism and diabetes. Diabetologia 2008 51 : 1937 1946.
7. Plaisance V, Thompson N, Niederhauser G, Haefliger JA, Nicod P, Waeber G et al. The mif gene is transcriptionally regulated by glucose in insulin-secreting cells. Biochem Biophys Res Commun 2002 295 : 174 181.
8. Waeber G, Calandra T, Bonny C, Bucala R. A role for the endocrine and pro-inflammatory mediator MIF in the control of insulin secretion during stress. Diabetes Metab Res Rev 1999 15 : 47 54.
9. Hanifi-Moghaddam P, Schloot NC, Kappler S, Seibler J, Kolb H. An association of autoantibody status and serum cytokine levels in type diabetes. Diabetes 2003 52 : 1137 1142.
10. Bojunga J, Kusterer K, Bacher M, Kurek R, Usadel KH, Renneberg H. Macrophage migration inhibitory factor and development of type 1 diabetes in non-obese diabetic mice. Cytokine 2003 21 : 179 186.
11. Stosic-Grujicic S, Stojanovic I, Maksimovoc-Ivanic D, Momcilovic M, Popadic D, Harhaji L et al. Macrophage migration inhibitory factor (MIF) is necessary for progression of autoimmune diabetes mellitus. J Cell Physiol 2008 215 : 665 675.
12. Cvetkovic I, Al-Abed Y, Miljkovic D, Maksimovic-Ivanic D, Bacher M, Lan HY et al. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune disease. Endocrinology 2005 146 : 2942 2951.
13. Paralkar V, Wistow G. Cloning the human gene for macrophage migration inhibitory factor (MIF). Genomics 1994 19 : 48 51.
14. Donn R, Alourfi Z, de Beneditti F, Meazza C, Zeggini E, Lunt M et al. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum 2002 46 : 2402 2409.
15. Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ et al. A functional promoter polymorphism in the macrophage migration inhibitor factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun 2002 3 : 170 176.
16. Barton A, Lamb R, Symmons D, Silman A, Thomson W, Worthington J et al. Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis. Genes Immun 2003 4 : 487 491.
17. Donn RP, Alourfi Z, Zeggini E, Lamb R, Jury F, Lunt M et al. A functional promoter haplotype of macrophage migration inhibitory factor (MIF) is linked and associated with juvenile idiopathic arthritis. Arthritis Rheum 2004 50 : 1604 1610.
18. Waeber G, Thompson N, Chautard T, Steinmann M, Nicod P, Pralong FP et al. Transcriptional activation of the macrophage-inhibitory factor gene by the corticotrophin-releasing factor by the cyclic adenosine 3′,5′- monophosphate responsive element-binding protein CREB in pituitary cells. Mol Endocrinol 1998 12 : 698 705.
19. Nobrega MA, Ovcharenko I, Afzal V, Rubin EM. Scanning human gene deserts for long-range enhancers. Science 2003 302 : 413.
20. Patterson CC, Carson DJ, Hadden DR. Epidemiology of childhood IDDM in Northern Ireland 1989-1994: low incidence in areas with highest population density and most household crowding. Diabetologia 1996 39 : 1063 1069.
21. McGartland CP, Robson PJ, Murray LJ, Cran GW, Savage MJ, Watkins DC et al. Fruit and vegetable consumption and bone mineral density: the Northern Ireland Young Hearts Project. Am J Clin Nutr 2004 80 : 1019 1023.
22. Lewontin RC. The interaction of selection and linkage. I: general considerations; heterotic models. Genetics 1964 49 : 49 67.
23. Clayton DG. SNPHAP: a program for estimating frequencies of large haplotypes of single nucleotide polymorphisms. Available at http://www-gene. cimr.cam.ac.uk/clayton/software/snphap.txt Last accessed 8th March 2006.
24. Johnson GC, Espositi L, Barrat BJ, Smith AN, Heward J, DiGenova G et al. Haplotype tagging for the identification of common disease genes. Nat Genet 2001 29 : 233 237.
25. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualisation of LD and haplotype maps. Bioinformatics 2005 21 : 263 265.
26. Sakaue S, Ishimaru S, Hizawa N, Ohtsuka Y, Tsujino I, Honda T et al. Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity. Int J Obes 2006 30 : 238 242.
27. The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007 449 : 851 861.
28. Plant BJ, Ghani S, O'Mahony MJ, Morgan L, O'Connor CM, Morgan K et al. Sarcoidosis and MIF gene polymorphism: a case-control study in an Irish population. Eur Respir J 2007 29 : 325 329.
29. Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of Type 1 diabetes. Nat Genet 2009 41 : 703 707.
30. Herder C, Klopp N, Baumert J, Muller M, Khuseyinova N, Meisinger C et al. Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Diabetologia 2008 51 : 276 284.