Obesity and abdominal wound healing in rats

Acta Cirurgica Brasileira

Volumn 25, Issue 1, 2010, Pages 86-92

  Biondo Simões, Maria De Lourdes Pessole ^a,b   Zammar, Guilherme Roberto ^a,c   Fernandes, Rodrigo Dos Santos ^a   Biondo Simões, Rachel ^a   De Mello, Flavia Stica Ritzdorf ^a   De Noronha, Lucia ^a,b  

^a PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^c UFPR ^*

Author keywords

Collagen; Obesity; Rats; Wound healing

Indexed keywords

COLLAGEN;

ABDOMINAL INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APONEUROSIS; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; EUTHANASIA; HISTOPATHOLOGY; LAPAROTOMY; MALE; NONHUMAN; OBESITY; RAT; WOUND HEALING; ABDOMINAL WALL; ANIMAL; DISEASE MODEL; METABOLISM; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SCAR; WISTAR RAT;

ABDOMINAL WALL; ANIMALS; CICATRIX; COLLAGEN; DISEASE MODELS, ANIMAL; ENERGY INTAKE; MALE; OBESITY; RANDOM ALLOCATION; RATS; RATS, WISTAR; WOUND HEALING;

EID: 76149146388     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/s0102-86502010000100018     Document Type: Article

References (34)

1. WHO - World Health Organization. Obesity and overweight. Fact sheet No 311 September 2006. Disponível em [http://www.who.int/mediacentre/ factsheets/fs311/en/index.html]. Acesso em 03/03/2009.
2. Stevens VJ, Obarzanek E, Cook NR, Lee IM, Appel LJ, Smith West D, Milas NC; Mattfeldt-Beman M; Belden L, Bragg C; Millstone M, Raczynski J, Brewer A, Singh B, Cohen J, Trials for the Hypertension Prevention Research Group. Trials for the Hypertension Prevention Research Group. Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II. Ann Intern Med. 2001;134(1):1-11.
3. Bult MJ, van Dalen T, Muller AF. Surgical treatment of obesity. Eur J Endocrinol. 2008;158(2):135-45.
4. Puzziferri N, Austrheim-Smith IT, Wolfe BM, Wilson SE, Nguyen NT. Three-year follow-up of a prospective randomized trial comparing laparoscopic versus open gastric bypass. Ann Surg. 2006;243(2):181-8.
5. Byrne TK. Complications of surgery for obesity. Surg Clin North Am. 2001;81(5):1181-93.
6. Livingston EH. Complications of bariatric surgery. Surg Clin North Am. 2005;85(4):853-68.
7. Nguyen NT, Goldman C, Rosenquist CJ, Arango A, Cole CJ, Lee SJ, Wolfe BM. Laparoscopic versus open gastric bypass: a randomized study of outcomes, quality of life, and costs. Ann Surg. 2001;234(3):279-89.
8. Nguyen NT, Ho HS, Palmer LS, Wolfe BM. A comparison study of laparoscopic versus open gastric bypass for morbid obesity. J Am Coll Surg. 2000;191(2):149-55.
9. Sugerman HJ, Kellum JM, Reines HD, DeMaria EJ, Newsome HH, Lowry JW. Greater risk of incisional hernia with morbidly obese than steroid-dependent patients and low recurrence with prefascial polypropylene mesh. Am J Surg. 1996;171(1):80-4.
10. Yahchouchy-Chouillard E, Aura T, Picone O, Etienne JC, Fingerhut A. Incisional hernias. I. Related risk factors. Dig Surg. 2003;20(1):3-9.
11. Bellon JM, Duran HJ. [Biological factors involved in the genesis of incisional hernia. Cir Esp. 2008;83(1):3-7.
12. Wilson JA, Clark JJ. Obesity: impediment to postsurgical wound healing. Adv Skin Wound Care. 2004;17(8):426-35.
13. Gårdlund B, Bitkover CY, Vaage J. Postoperative mediastinitis in cardiac surgery - microbiology and pathogenesis. Eur J Cardiothorac Surg. 2002;21(5):825-30.
14. Nascimento AP, Costa AM. Overweight induced by high-fat diet delays rat cutaneous wound healing. Br J Nutr. 2006;96(6):1069-77.
15. Sauerland S, Korenkov M, Kleinen T, Arndt M, Paul A. Obesity is a risk factor for recurrence after incisional hernia repair. Hernia. 2004; 8(1):42-6.
16. Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat Med. 2009;15(2):159-68.
17. Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab. 2000;11(8):327-32.
18. Levin BE, Hogan S, Sullivan AC. Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol. 1989;256(3):R766-71.
19. American Veterinary Medical Association. Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia). June 2007. Available from http://www.avma.org/resources/euthanasia.pdf, acesso 11 mar. 2009.
20. BRASIL. Resolução n.o 714 do Conselho Federal de Medicina Veterinária, de 20 de junho de 2002. Dispõe sobre procedimentos e métodos de eutanásia em animais e dá outras providências.
21. Johnson DW, Isbel NM, Brown AM, Kay TD, Franzen K, Hawley CM, Campbell SB, Wall D, Griffin A, Nicol DL. The effect of obesity on renal transplant outcomes. Transplantation. 2002;74(5):675-81.
22. Chang DW, Wang B, Robb GL, Reece GP, Miller MJ, Evans GR, Langstein HN, Kroll SS. Effect of obesity on flap and donor-site complications in free transverse rectus abdominis myocutaneous flap breast reconstruction. Plast Reconstr Surg. 2000;105(5):1640-8.
23. Almahmeed T, Gonzalez R, Nelson LG, Haines K, Gallagher SF, Murr MM. Morbidity of anastomotic leaks in patients undergoing Roux-en-Y gastric bypass. Arch Surg. 2007;142(10):954-7.
24. Lorden JF, Caudle A. Behavioral and endocrinological effects of single injections of monosodium glutamate in the mouse. Neurobehav Toxicol Teratol. 1986;8(5):509-19.
25. Chen Y, Heiman ML. Increased weight gain after ovariectomy is not a consequence of leptin resistance. Am J Physiol Endocrinol Metab. 2001;280(2):E315-22.
26. Naderali EK, Fatani S, Williams G. Chronic withdrawal of a high-palatable obesity-inducing diet completely reverses metabolic and vascular abnormalities associated with dietary-obesity in the rat. Atherosclerosis. 2004;172(1):63-9.
27. Lima-Leopoldo AP, Sugizaki MM, Leopoldo AS, Carvalho RF, Nogueira CR, Nascimento AF, Martinez PF; Luvizotto RA; Padovani CR; Cicogna AC. Obesity induces upregulation of genes involved in myocardial Ca2+ handling. Braz J Med Biol Res. 2008;41(7):615-20.
28. Nascimento AF, Sugizaki MM, Leopoldo AS, Lima-Leopoldo AP, Luvizotto RA, Nogueira CR, Cicogna AC. A hypercaloric pellet-diet cycle induces obesity and co-morbidities in Wistar rats. Arq Bras Endocrinol Metabol. 2008;52(6):968-74.
29. Montesano R, Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci USA. 1988;85(13):4894-7.
30. Clark RA, Folkvord JM, Hart CE, Murray MJ, McPherson JM. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J Clin Invest. 1989;84(3):1036-40.
31. Schiro JA, Chan BM, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Martinez PF, Luvizotto RA, Padovani CR, Cicogna AC. Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 1991;67(2):403-10.
32. Woodley DT, Yamauchi M, Wynn KC, Mechanic G, Briggaman RA. Collagen telopeptides (cross-linking sites) play a role in collagen gel lattice contraction. J Invest Dermatol. 1991;97(3):580-5.
33. Garner WL, Karmiol S, Rodriguez JL, Smith DJ, Jr., Phan SH. Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts. J Invest Dermatol. 1993;101(6):875-9.
34. Cooney R, Iocono J, Maish G, Smith JS, Ehrlich P. Tumor necrosis factor mediates impaired wound healing in chronic abdominal sepsis. J Trauma. 1997;42(3):415-20.