Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 2, 2010, Pages 872-878

  Carr, Richard D ^a,d   Larsen, Marianne O ^a   Jelic, Katarina ^a   Lindgren, Ola ^b   Vikman, Jenny ^b   Holst, Jens J ^c   Deacon, Carolyn F ^c   Ahrén, Bo ^b  

^a NOVO NORDISK A S   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INCRETIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DEGRADATION; ENZYME ACTIVITY; HORMONE METABOLISM; HORMONE RELEASE; HUMAN; INGESTION; LEAN BODY WEIGHT; MALE; MEAL; OBESITY; PRIORITY JOURNAL;

EID: 76149140857     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2054     Document Type: Article

References (28)

1. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V 1993 Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol 138:159-166
2. Orskov C, Wettergren A, Holst JJ 1996 Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol 31:665-670
3. Holst JJ, Vilsbøll T, Deacon CF 2009 The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 297:127-136
4. Dunning BE, Foley JE, Ahrén B 2005 α-Cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 48:1700-1713
5. Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ 1995 Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44:1126-1131
6. Mentlein R 1999 Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept 85:9-24
7. Deacon CF, Ahrén B, Holst JJ 2004 Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of type 2 diabetes? Expert Opin Investig Drugs 13:1091-1102
8. Lugari R, Dei Cas A, Ugolotti D, Barilli AL, Camellini C, Ganzerla GC, Luciani A, Salerni B, Mittenperger F, Nodari S, Gnudi A, Zandomeneghi R 2004 Glucagon-like peptide 1 (GLP-1) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion. Horm Metab Res 36:111-115
9. Toft-Nielsen MB, Damholt MB, Madsbad S, Hilsted LM, Hughes TE, Michelsen BK, Holst JJ 2001 Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetes patients. J Clin Endocrinol Metab 86:3717-3723
10. Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ 2001 Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50:609-613
11. Rask E, Olsson T, Söderberg S, Johnson O, Seckl J, Holst JJ, Ahrén B 2001 Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men. Diabetes Care 24:1640-1645
12. Vilsbøll T, Krarup T, Sonne J, Madsbad S, Vølund A, Juul AG,Holst JJ 2003 Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 88:2706-2713
13. Medhus AW, Lofthus CM, Bredesen J, Husebye E 2001 Gastric emptying: the validity of the paracetamol absorption test adjusted for individual pharmacokinetics. Neurogastroenterol Motil 13:179-185
14. Orskov C, Rabenhøj L, Wettergren A, Kofod H, Holst JJ 1994 Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes 43:535-539
15. Deacon CF, Nauck MA, Meier J, Hücking K, Holst JJ 2000 Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 85:3575-3581
16. Gunnarsson PT, Winzell MS, Deacon CF, Larsen MO, Jelic K, Carr RD, Ahrén B 2006 Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice. Endocrinology 147:3173-3180
17. Verdich C, Toubro S, Buemann B, Lysgård Madsen J, Juul Holst J, Astrup A 2001 The role of postprandial releases of insulin and incretin hormones in meal-induced satiety - effect of obesity and weight reduction. Int J Obes Relat Metab Disord 25:1206-1214
18. Ranganath LR, Beety JM, Morgan LM, Wright JW, Howland R, Marks V 1996 Attenuated GLP-1 secretion in obesity: cause or consequence? Gut 38:916-919
19. Muscelli E, Mari A, Casolaro A, Camastra S, Seghieri G, Gastaldelli A, Holst JJ, Ferrannini E 2008 Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 57:1340-1348
20. Rask E, Olsson T, Söderberg S, Holst Jj J, Tura A, Pacini G, Ahrén B 2004 Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose tolerance. Metabolism 53:624 -631
21. Vollmer K, Holst JJ, Baller B, Ellrichmann M, Nauck MA, Schmidt WE, Meier JJ 2008 Predictors of incretin concentrations in subjects with normal, impaired and diabetic glucose tolerance. Diabetes 57: 678-687
22. 1c levels, but is not acutely affected by food intake. Eur J Endocrinol 155: 485-493
23. Vollmer K, Gardiwal H, Menge BA, Goetze O, Deacon CF, Schmidt WE, Holst JJ, Meier JJ 2009 Hyperglycemia acutely lowers the postprandial excursions of glucagon-like peptide-1 and gastric inhibitory polypeptide in humans. J Clin Endocrinol Metab 94: 1379-1385
24. Miholic J, Orskov C, Holst JJ, Kotzerke J, Meyer HJ 1991 Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), reactive hypoglycemia after total gastrectomy. Dig Dis Sci 36:1361-1370
25. Verdich C, Madsen JL, Toubro S, Buemann B, Holst JJ, Astrup A 2000 Effect of obesity and major weight reduction on gastric emptying. Int J Obes Relat Metab Disord 24:899-905
26. Carr RD, Larsen MO, Winzell MS, Jelic K, Lindgren O, Deacon CF, Ahrén B 2008 Incretin and islet hormonal responses to fat and protein ingestion in healthy men. Am J Physiol Endocrinol Metab 295: E779-E784
27. Hansen L, Deacon CF, Orskov C, Holst JJ 1999 Glucagon-like peptide-1 (7-36)amide is transformed to glucagon-like peptide-1(9-36)amideby dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140:5356-5363
28. Ahrén B, Pacini G 2004 Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess β cell function in clinical studies. Eur J Endocrinol 150:97-104