Chemoprevention of MNU and testosterone induced prostate carcinogenesis by Calcitriol (vitamin D3) in adult male albino Wistar rats

Annals of Cancer Research and Therapy

Volumn 14, Issue 1, 2006, Pages 12-18

  Senthilkumar, K ^a   Arunkumar, A ^a   Sridevi, N ^a   Vijayababu, M R ^a   Kanagaraj, P ^a   Venkataraman, P ^a   Aruldhas, M M ^a   Srinivasan, N ^a   Arunakaran, J ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Calcitriol; Chemoprevention; Methyl nitroso urea; Prostate cancer; Prostatic intraepithelial neoplasia

Indexed keywords

EID: 76149137446     PISSN: 13446835     EISSN: None     Source Type: Journal    
DOI: 10.4993/acrt.14.12     Document Type: Article

References (34)

1. American Cancer society (2003) Cancer Facts and Figures 2003.
2. Quinn, M. and Babb, P. (2002) Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons, BJU International 90: 162-164.
3. Leav, I., Ho, S.M., Ofner, P., Merk, F.B., Kwan, P.W. and Damassa D. (1988) Biochemical alterations in sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats. J. Natl. Cancer Inst. 80: 1045-1053.
4. Wong, Y.C., Wang, Y.Z. and Tam, N.N.C. (1998) The prostate gland and carcinogenesis It. J. Anat. Embryol. 103: 237-252.
5. Mccormick, D.L. and Rao, K.V.N. (1999) Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever Rat. Eur. Urol. 35: 464-467.
6. Arunkumar, A., Vijayababu, M.R., Venkataraman, P., Senthilkumar, K. and Arunakaran, J. (2006) Chemoprevention of rat prostate carcinogenesis by diallyl disulfide, an organosulfur compound of garlic. Biological and Pharmaceutical Bulletin. (29: 375-379).
7. Bostwick, D.G., Pacelli, A. and Antonio, L.B. (1996) Molecular biology of prostatic intraepithelial neoplasia. Prostate 29: 117-134.
8. Haggman, M.J., Wojno, K.J., Pearsall, C.P. and Macoska, J.A. (1997) Allelic loss of 8p sequences in prostatic intraepithelial neoplasia and carcinoma. Urology 50: 643-647.
9. Bostwick, D.G. (1995) High-grade prostatic intraepithelial neoplasia: the most likely precursor of prostate cancer. Cancer 75: 1823-1836.
10. Schwartz, G.G. and Hulka, B.S. (1990) Is vitamin D deficiency a risk factor for prostate carcinoma? (hypothesis). Anticancer Res. 10: 1307-1311.
11. Hanchette C.L., Schwartz G.G. (1992) Geographic patterns of prostate cancer mortality evidence for a protective effect of ultraviolet radiation. Cancer 70: 2861-2869.
12. MacLaughulin, J. and Holick, M. (1985) Aging decreases the capacity of human skin to produce vitamin D3. J. Clin. Invest. 76: 1536-1538.
13. Fife, R.S., Sledge, G.W. and Proctor, C. (1997) Effects of vitamin D3 on proliferation of cancer cells in vitro. Cancer Lett 120: 65-69.
14. Van den Bemd, G.J., Pols, H.A. and Van Leewen, J.P. (2000) Antitumor effects of 1,25-dihydroxyvitamin D3 and vitamin D analogs. Curr. Pharm. Des. 6: 717-732.
15. Colston, K.W., Chander, S.K., Mackay, A.G. and Coombes, R.C. (1992) Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro. Biochem. Pharmacol. 44: 693-702.
16. Stewart, L.V. and Weigel, N.L. (2004) Minireview: Vitamin D and prostate cancer. Exp. Biol. Med. 229: 277-284.
17. Carlos, M., Stable, P., Schwartz, G.G., Farinas. A., Finegold, M., Binderup, L., Howard, G.A. and Roos, B.A. (2002) The Gγ/T15 Transgenic mouse model of androgen independent prostate cancer: Target cells of carcinogenesis and the effect of the vitamin D analogue EB1089. Cancer Epid. Biol. Prev. 11: 555-563
18. Tenniswood, M., Bird, C.E. and Clark, A.F. (1976) Acid phosphatases: Androgen dependent markers of rat prostate. Can. J. Biochem. 54: 350-357.
19. Verlinden, L., Verstuyf, A., Convents, R., Marcelis, S., Van Camp, M. and Bouillon, R. (1998) Action of 1,25(OH) 2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells. Mol. Cell. Endocrinol. 142: 57-65.
20. Otoshi, T., Iwata, H., Kitano, M., Nishizawa, Y., Morii, H., Yano, Y., Otoni, S. and Fukushima, S. (1995) Inhibition of intestinal tumor development in rat multiorgan carcinogenesis and abberant crypt foci in rat colon carcinogenesis by 22-oxa-calcitriol, a syntheteic analogue of 1α,25-dihydroxyvitamin D3. Carcinogenesis 16: 2091-2097.
21. Kensler, T.W., Dolan, P.M., Gange, S.J., Lee, J.K., Wang, Q. and Posner, G.H. (2000) Conceptually new deltenoids (vitamin D analogs) inhibit multistage skin tumorogenesis. Carcinogenesis 21: 1341-1345.
22. Liao, Z., Boileau, T.W.M., Erdman, J.W. and Clinton, S.K. (2002) Interrelationships among angiogenesis, proliferation, and apoptosis in the tumor microenvironment during N-methyl-N-nitrosourea androgen-induced prostate carcinogenesis in rats. Carcinogenesis 23: 1701-1712.
23. Zuke, M.C. and Coffey, D.S. (1994) The male accessory tissue: structure, Androgen action and physiology. In: Knobil E. and Neul J.D., editors, The physiology of Reproduction. New York: Raven Press Ltd.; p. 1436-1479.
24. Shao, T.C., Kong, A.Y. and Cunningham, G.R. (1987) Acid phosphatase activity a marker of androgen status action in prostate explant cultures. Prostate 10: 69-77.
25. Reif, A.F., Schilesinger, R.M., Fish, C.A. and Robinson, C.M. (1973) Acid phosphatase isoenzyme in cancer of the prostate. Cancer 31: 689-699.
26. Bosland, M.C. (1996) Chemical and hormonal induction of prostate cancer in animal models. Urol. Oncol. 2: 103-110.
27. Foster, C.S., Bostwick, D.G., Bonkhoff, H., Damber, J.E., van der Kwast, T., Montironi, R. and Sakr, W.A. (2000) Cellular and molecular pathology of prostate cancer precursors. Scand. J. Urol. Nephrol. Suppl. 205: 19-43.
28. Christov, K.T., Moon, R.C., Lantvit, D.D., Boone, C.W., Steele V.E., Lubet, R.A., Kelloff, G.J. and Pezzuto, J.M. (2002) 9-cis-Retinoic Acid but Not 4- (Hydroxyphenyl) retinamide Inhibits Prostate Intraepithelial Neoplasia in Noble Rats. Cancer Res. 62: 5178-5182.
29. Bosland, M.C., Prinsen, M.K., Dirksen, T.J.M. and Spit, B.J. (1990) Characterization of adenocarcinomas of the dorsolateral prostate induced wistar rats by N-methyl-N-nitrosourea, 7,12-di-methyl-4-aminobenz(a)anthrazene and 3,2′-dimethyl-4-aminobiphenyl following sequential treatment with cyproterone acetate and testosterone propionate. Cancer Res. 50: 7000-709.
30. Rao, K.V.N., Johnson, W.D., Bosland, M.C., Lubet, R.A., Steele, V.E., Kellof, G.A. and Mccormick, D.L. (1999) Chemoprevention of rat carcinogenesis by early and delayed administration of dehydroepiandrosterone. Cancer Res. 59: 3084-3089.
31. Miller, G.J., Stapleton, G.E., Ferrara, J.A., Lucia, M.S., Pfister, S., Hedlund, T.E. and Upadhya, P. (1992) The huma prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25 dihydroxyvitamin D3. Cancer Res. 52: 515-520.
32. Miller, G. (1999) Vitamin D and prostate cancer: biologic interactions and clinical potentials. Cancer metastasis Rev. 17: 353-360.
33. Oikawa, T., Yoshida, Y., Shimamura, M., Ashino-Fuse, H., Iwaguchi, T. and Tominaga, T. (1991) Antitumor effect of 22-oxa-1α,25dihydroxyvitamin D3, a potent angiogenesis inhibitor, on rat mammary tumors induced by 7,12-dimethylben-z(a)anthracene. Anticancer Drugs 2: 475-480.
34. Shokravi, M.T., Marcus, D.M., Alroy, J., Egan, K., Saornil, M.A. and Albert. D.M. (1995) Vitamin D inhibits angiogenesis in transgenic murine retinoblastoma stomas. Invest. Opthalmol. 36: 83-87.