Synthesis and characterization of methotrexate polyethylene glycol esters as a drug delivery system

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 2, 2010, Pages 147-153

  Yousefi, Gholamhossein ^a   Foroutan, Seyed Mohsen ^a   Zarghi, Afshin ^a   Shafaati, Alireza ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Drug targeting; Methotrexate; Pegylation; Stability

Indexed keywords

DICYCLOHEXYLCARBODIIMIDE; ESTER; MACROGOL; MACROGOL 3500; MACROGOL 5000; MACROGOL 750; METHOTREXATE; POLYMER; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ARTICLE; CATALYST; CHEMICAL BOND; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG PURIFICATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; PHYSICAL CHEMISTRY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

ANTIMETABOLITES, ANTINEOPLASTIC; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; METHOTREXATE; POLYETHYLENE GLYCOLS; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 76149135715     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.147     Document Type: Article

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