Quantitative determination of dipyridamole in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 24, Issue 3, 2010, Pages 268-273

  Qin, Ting ^a   Qin, Feng ^a   Li, Ning ^a   Lu, Shan ^a   Liu, Wei ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dipyridamole; HPLC MS MS; Human plasma; Pharmacokinetic study

Indexed keywords

DISEASE CONTROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN);

CEREBROVASCULAR DISEASE; CLINICAL THERAPY; DIPYRIDAMOLE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS-MS; HUMAN PLASMAS; ITS APPLICATIONS; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION; QUANTITATIVE DETERMINATIONS;

METHANOL;

AMMONIUM ACETATE; DIAZEPAM; DIPYRIDAMOLE; METHANOL;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMICAL REACTION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FOOD AND DRUG ADMINISTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; STANDARD; TANDEM MASS SPECTROMETRY; THERMOSTABILITY; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 76149130392     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1283     Document Type: Article

References (12)

1. Al-Bahrani A, Taha S, Shaath H and Bakhiet M. TNF-alpha and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents. Current Neurovascular Research 2007; 4: 31-37.
2. Barberi M, Merlin JL and Weber B. Sensitive determination of free and plasma protein-bound dipyridamole by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 1991; 565: 511-515.
3. Chen M, Granvil C, Ji QC, Padval MV and Kansra VV. Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous quantitation of prednisolone and dipyridamole in human plasma and its application in a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 2009, DOI:10.1016/j.jpba.2009.02.017.
4. Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, May 2001. Available from: http://www.fda.gov/CVM.
5. Gresele P, Arnout J, Dechmyn H and Vermylen J. Mechanism of antiplatelet action of dipyridamole in whole blood: modulation of adenosine concentration and activity. Thrombosis and Haemostasis 1986; 55: 12-18.
6. Lugnier C, Schoeff ter P, Le Bec A, Strouthou E and Stoclet JC. Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta. Biochemical Pharmacology 1986; 35: 1743-1751.
7. Luliano L, Ghiselli A, Alessandri C, Bonavita MS and Violi F. Superoxide anion scavenging property of dipyridamole. Thrombosis and Haemostasis 1989; 61: 149.
8. Steyn JM. Spectrofl uorimetric determination of dipyridamole in serum - a comparison of two methods. Journal of Chromatography B: Biomedical Sciences and Applications 1979; 164: 487-494.
9. Wang N, Xu F, Zhang ZJ, Yang C, Sun XH and Li JH. Simultaneous determination of dipyridamole and salicylic acid in human plasma by high performance liquid chromatography-mass spectrometry. Biomedical Chromatography 2008; 22: 149-156.
10. Williams C, Huang CS, Erb R and Gonzalez MA. High-performance liquid chromatographic assay for plasma dipyridamole monitoring. Journal of Chromatography B: Biomedical Sciences and Applications 1981; 225: 225-230.
11. Wolfram KM and Bjornsson TD. High-performance liquid chromatographic analysis of dipyridamole in plasma and whole blood. Journal of Chromatography B: Biomedical Sciences and Applications 1980; 183: 57-64.
12. Yadavm M, Patel D, Singhal P, Prasad R, Goswami S, Shrivastav PS and Pande UC. Eff ect of collision-activated dissociation gas and collision energy on the fragmentation of dipyridamole and its rapid and sensitive liquid chromatography/electrospray ionization tandem mass spectrometric determination in human plasma. Rapid Communication in Mass Spectrometry 2008; 22: 511-518.