Effect of recombinant human bone morphogenetic protein-2 on bone regeneration in large defects of the growing canine skull after dura mater replacement with a dura mater substitute: Laboratory investigation

Journal of Neurosurgery

Volumn 112, Issue 2, 2010, Pages 319-328

  He, Dongmei ^a,e   Genecov, Davi D G ^a   Herbert, Morley ^a   Barcelo, Raul ^a   Elsalanty, Mohammed E ^b   Weprin, Bradley E ^c   Opperman, Lynne A ^d  

^a Cleft Lip and Palate Treatment Center   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d BAYLOR COLLEGE OF DENTISTRY   (United States)

^e SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Bone generation; Dura mater repair; Large cranial defect; Recombinant human bone morphogenetic protein 2

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BOVINE SKIN COLLAGEN; COLLAGEN; COLLAGEN CERAMIC MATRIX; COLLAGEN SPONGE; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEMINERALIZATION; BONE MATRIX; BONE REGENERATION; CONTROLLED STUDY; DRUG EFFECT; DURA MATER; EXPERIMENTAL DOG; HISTOPATHOLOGY; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; SKULL DEFECT; SKULL DEVELOPMENT;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CATTLE; COLLAGEN; DOGS; DRUG IMPLANTS; DURA MATER; HUMANS; MALE; RECOMBINANT PROTEINS; SKULL; TREATMENT OUTCOME;

EID: 76149126738     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2009.1.JNS08976     Document Type: Article

References (49)

1. Alam I, Asahina I, Ohmamiuda K, Enomoto S: Comparative study of biphasic calcium phosphate ceramics impregnated with rhBMP-2 as bone substitutes. J Biomed Mater Res 54: 129-138, 2001
2. Barnes B, Boden SD, Louis-Ugbo J, Tomak PR, Park JS, Park MS, et al: Lower dose of rhBMP-2 achieves spine fusion when combined with an osteoconductive bulking agent in non-human primates. Spine 30:1127-1133, 2005
3. Bauer TW: An overview of the histology of skeletal substitute materials. Arch Pathol Lab Med 131:217-224, 2007
4. Boyne PJ, Lilly LC, Marx RE, Moy PK, Nevins M, Spagnoli DB, et al: De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg 63:1693-1707, 2005
5. Burkus JK, Gornet MF, Dickman CA, Zdeblick TA: Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337-349, 2002
6. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, et al: Identification of transforming growth factor beta family members present in bone-inductive protein puri-fied from bovine bone. Proc Natl Acad Sci U S A 87:9843-9847, 1990
7. Chang SC, Chuang H, Chen YR, Yang LC, Chen JK, Mardini S, et al: Cranial repair using BMP-2 gene engineered bone marrow stromal cells. J Surg Res 119:85-91, 2004
8. Chang SC, Wei FC, Chuang H, Chen YR, Chen JK, Lee KC, et al: Ex vivo gene therapy in autologous critical-size craniofacial bone regeneration. Plast Reconstr Surg 112:1841-1850, 2003
9. Chen TM, Wang HJ: Cranioplasty using allogeneic perforated demineralized bone matrix with autogenous bone paste. Ann Plast Surg 49:272-277, 2002
10. Cho YR, Gosain AK: Biomaterials in craniofacial reconstruction. Clin Plast Surg 31:377-385, 2004
11. Ducic Y: Titanium mesh and hydroxyapatite cement cranioplasty: a report of 20 cases. J Oral Maxillofac Surg 60:272-276, 2002
12. Elsalanty ME, Por YC, Genecov DG, Salyer KE, Wang Q, Barcelo CR, et al: Recombinant human BMP-2 enhances the effects of materials used for reconstruction of large cranial defects. J Oral Maxillofac Surg 66:277-285, 2008
13. Eppley BL, Hollier L, Stal S: Hydroxyapatite cranioplasty: 2. Clinical experience with a new quick-setting material. J Craniofac Surg 14:209-214, 2003
14. Fiorellini JP, Howell TH, Cochran D, Malmquist J, Lilly LC, Spagnoli D, et al: Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. J Periodontol 76:605-613, 2005
15. Fleckenstein KB, Cuenin MF, Peacock ME, Billman MA, Swiec GD, Buxton TB, et al: Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium. J Periodontol 77:39-45, 2006
16. Gazdag AR, Lane JM, Glaser D, Forster RA: Alternatives to autogenous bone graft: Efficacy and indications. J Am Acad Orthop Surg 3:1-8, 1995
17. Genecov DG, Kremer M, Agarwal R, Salyer KE, Barcelo CR, Aberman HM, et al: Norian craniofacial repair system: compatibility with resorbable and nonresorbable plating materials. Plast Reconstr Surg 120:1487-1495, 2007
18. Glassman SD, Dimar JR, Carreon LY, Campbell MJ, Puno RM, Johnson JR: Initial fusion rates with recombinant human bone morphogenetic protein-2/compression resistant matrix and a hydroxyapatite and tricalcium phosphate/collagen carrier in posterolateral spinal fusion. Spine 30:1694-1698, 2005
19. Glowacki J, Altobelli D, Mulliken JB: The fate of mineralized and demineralized osseous implants in cranial defects. Calcif Tissue Int 33:71-76, 1981
20. Gosain AK: Plastic Surgery Educational Foundation DATA Committee. Biomaterials for reconstruction of the cranial vault. Plast Reconstr Surg 116:663-666, 2005
21. Gosain AK, Santoro TD, Song LS, Capel CC, Sudhakar PV, Matloub HS: Osteogenesis in calvarial defects: contribution of the dura, the pericranium, and the surrounding bone in adult versus infant animals. Plast Reconstr Surg 112:515-527, 2003
22. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, et al: Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 84:2123-2134, 2002
23. Greenwald JA, Mehrara BJ, Spector JA, Chin GS, Steinbrech DS, Saadeh PB, et al: Biomolecular mechanisms of calvarial bone induction: immature versus mature dura mater. Plast Reconstr Surg 105:1382-1392, 2000
24. Greenwald JA, Mehrara BJ, Spector JA, Fagenholz PJ, Saadeh PB, Steinbrech DS, et al: Immature versus mature dura mater: II. Differential expression of genes important to calvarial reossification. Plast Reconstr Surg 106:630-638, 2000
25. Haddad AJ, Peel SA, Clokie CM, Sándor GK: Closure of rabbit calvarial critical-sized defects using protective composite allogeneic and alloplastic bone substitutes. J Craniofac Surg 17: 926-934, 2006
26. Handschel J, Wiesmann HP, Stratmann U, Kleinheinz J, Meyer U, Joos U: TCP is hardly resorbed and not osteoconductive in a non-loading calvarial model. Biomaterials 23:1689-1695, 2002
27. Hobar PC, Masson JA, Wilson R, Zerwekh J: The importance of the dura mater in craniofacial surgery. Plast Reconstr Surg 98:217-225, 1996
28. Hobar PC, Schreiber JS, McCarthy JG, Thomas PA: The role of the dura mater in cranial bone regeneration in the immature animal. Plast Reconstr Surg 92:405-410, 1993
29. Hollinger JO, Batistone GC: Biodegradable bone repair materials. Synthetic polymers and ceramics. Clin Orthop Relat Res 207:290-305, 1986
30. Hopper RA, Zhang JR, Fourasier VL, Morova-Protzner I, Protzner KF, Pang CY, et al: Effect of isolation of periosteum and dura mater on the healing of rabbit calvarial inlay bone grafts. Plast Reconstr Surg 107:454-462, 2001
31. Kao ST, Scott DD: A review of bone substitutes. Oral Maxillofac Surg Clin North Am 19:513-521, 2007
32. Khan SN, Fraser JF, Sandhu HS, Cammisa FP Jr, Girardi FP, Lane JM: Use of osteopromotive growth factors, demineralized bone matrix, and ceramics to enhance spinal fusion. J Am Acad Orthop Surg 13:129-137, 2005
33. Laffargue P, Hildebrand HF, Rtaimate M, Frayssinet P, Amoureux JP, Marchandise X: Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects. Bone 25:55S-58S, 1999
34. Martin GJ Jr, Boden SD, Marone MA, Marone MA, Moskovitz PA: Posterolateral intertransverse process spinal arthrodesis with rhBMP-2 in a nonhuman primate: important lessons learned regarding dose, carrier, and safety. J Spinal Disord 12:179-186, 1999
35. McKay B, Sandhu HS: Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications. Spine 27 (16 Suppl):S66-S85, 2002
36. Moreira-Gonzalez A, Jackson IT, Miyawaki T, Barakat K, DiNick V: Clinical outcome in cranioplasty: critical review in long-term follow-up. J Craniofac Surg 14:144-153, 2003
37. Moss SD, Joganic E, Manwaring KH, Beals SP: Transplanted demineralized bone graft in cranial reconstructive surgery. Pediatr Neurosurg 23:199-204, 1995
38. Neigel JM, Ruzicka PO: Use of demineralized bone implants in orbital and craniofacial reconstruction and a review of the literature. Ophthal Plast Reconstr Surg 12:108-120, 1996
39. Ozcelik D, Turan T, Kabukcuoglu F, Ugurlu K, Ozturk O, Basak M, et al: Bone induction capacity of the periosteum and neonatal dura mater in the setting of the rat zygomatic arch fracture model. Arch Facial Plast Surg 5:301-308, 2003
40. Por YC, Barcelo CR, Salyer KE, Genecov DG, Troxler K, Gendler E, et al: Bone generation in the reconstruction of a critical size calvarial defect in an experimental model. J Craniofac Surg 19:383-392, 2008
41. Ripamonti U, Richter PW, Nilen RW, Renton L: The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus. J Cell Mol Med 12:2609-2621, 2008
42. Salyer KE, Bardach J, Squier CA, Gendler E, Kelly KM: Cranioplasty in the growing canine skull using demineralized perforated bone. Plast Reconstr Surg 96:770-779, 1995
43. Salyer KE, Gendler E, Menendez J, Simon TR, Kelly KM, Bardach J: Demineralized perforated bone implants in craniofacial surgery. J Craniofac Surg 3:55-62, 1992
44. Salyer KE, Gendler E, Squier CA: Long-term outcome of extensive skull reconstruction using demineralized perforated bone in Siamese twins joined at the skull vertex. Plast Reconstr Surg 99:1721-1726, 1997
45. Schmitz JP, Hollinger JO: A preliminary study of the osteogenic potential of a biodegradable alloplastic-osteoinductive alloimplant. Clin Orthop Relat Res 237:245-255, 1988
46. Schwartz Z, Somers A, Mellonig JT, Carnes DL Jr, Wozney JM, Dean DD, et al: Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material. J Periodontol 69:1337-1345, 1998
47. Seeherman H, Wozney J, Li R: Bone morphogenetic protein delivery systems. Spine 27 (16 Suppl):S16-S23, 2002
48. Sheehan JP, Sheehan JM, Seeherman H, Quigg M, Helm GA: The safety and utility of recombinant human bone morphogenetic protein-2 for cranial procedures in a nonhuman primate model. J Neurosurg 98:125-130, 2003
49. Shi L, Shi WJ, Zhai SQ, Yang WY: Histological study of experimental reconstructive materials for repair of lateral skull base and dura mater defects in dogs. Acta Otolaryngol 123:552-554, 2003