Simple and sensitive HPLC method for determination of amrubicin and amrubicinol in human plasma: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 24, Issue 3, 2010, Pages 301-306

  Ando, Reiko ^a   Makino, Yoshinori ^a   Tamura, Tomohide ^a   Yamamoto, Noboru ^a   Nishigaki, Rena ^a   Kimura, Takehiro ^a   Yokote, Nobuaki ^a   Yamamoto, Hiroshi ^a  

^a NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Amrubicin; Amrubicinol; Cancer; Monolithic column; Protein precipitation

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PLASMA (HUMAN); PROTEINS;

AMRUBICIN; AMRUBICINOL; CANCER; CLINICAL PHARMACOKINETICS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; HUMAN PLASMAS; MONOLITHIC COLUMNS; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION; SIMPLE++;

DISEASES;

ACETIC ACID; AMRUBICIN; AMRUBICINOL; DRUG METABOLITE; GYRASE INHIBITOR; METHANOL; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; EVAPORATION; EXCITATION; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PLASMA; PRECIPITATION;

EID: 76149120424     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1289     Document Type: Article

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