Measurement of fexofenadine concentration in micro-sample human plasma by a rapid and sensitive LC-MS/MS employing protein precipitation: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 24, Issue 3, 2010, Pages 335-341

  Guo, Daqing ^a,b,c   Zou, Jianjun ^a   Zhu, Yubing ^a   Lou, Sheng ^a   Fan, Hongwei ^a   Qin, Qun ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Fexofenadine; LC MS MS; Pharmacokinetic; Protein precipitation

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); POSITIVE IONS; PROTEINS;

CLINICAL PHARMACOKINETICS; FEXOFENADINE; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS; MEASUREMENTS OF; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION; SIMPLE++;

PHARMACOKINETICS;

AMMONIUM ACETATE; FEXOFENADINE; FORMIC ACID; GLIPIZIDE;

ACCURACY; ARTICLE; CHROMATOGRAPHY; DRUG FORMULATION; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PRECIPITATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; STANDARD;

EID: 76149118427     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1296     Document Type: Article

References (12)

1. Bharathi VD, Radharani K, Jagadeesh B, Ramulu G, Bhushan I, Naidu A and Mullangi R. LC-MS-MS assay for simultaneous quantifi cation of fexofenadine and pseudoephedrine in human plasma. Chromatographia 2008; 67: 461-466.
2. Dams R, Huestis MA, Lambert WE and Murphy CM. Matrix eff ect in bioanalysis of illicit drugs with LC-MS/MS: infl uence of ionization type, sample preparation, and biofl uid. Journal of American Society for Mass Spectrometry 2003; 14: 1290-1294.
3. Hofmann U, Seiler M, Drescher S and Fromm MF. Determination of fexofenadine in human plasma and urine by liquid chromatography-mass spectrometry. Journal of Chromatography B 2002; 766: 227-233.
4. Hubert Ph, Chiap P, Crommen J, Boulanger B, Chapuzet E, Mercier N, Bervoas-Martin S, Chevalier P, Grandjean D, Lagorce P, Lallier M, Laparra MC, Laurentie M and Nivet JC. The SFSTP guide on the validation of chromatographic methods for drug bioanalysis Washington conférence to the laboratory. Analytica Chimica Acta 1999; 391: 135-148.
5. Isleyen EAO, Ozden T, Ozilhan S and Toptan S. Quantitative determination of fexofenadine in human plasma by HPLC-MS. Chromatographia 2007; 66: S109-S113.
6. Miura M, Unob T, Tateishi T and Suzuki T. Determination of fexofenadine enantiomers in human plasma with high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 2007; 43: 741-745.
7. Nirogi RV, Kandikere VN, Shukla M, Mudigonda K, Maurya S and Komarneni P. Quantifi cation of fexofenadine in human plasma by liquid chromatography coupled to electrospray tandem mass spectrometry using mosapride as internal standard. Biomedical Chromatography 2007; 21: 209-216.
8. Pathak SM, Kumar AR, Musmade P and Udupa N. A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma-application to preclinical pharmacokinetics. Talanta 2008; 76: 338-346.
9. Robbins DK, Castles MA, Pack DJ, Bhargava VO and Weir SJ. Dose proportionality and comparison of single and multiple dosepharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers. Biopharmaceutics and Drug Disposition 1998; 19: 455-563.
10. Unoa T, Yasui-Furukori N, Takahata T, Sugawara K and Tateishi T. Liquid chromatographic determination of fexofenadine in human plasma with fl uorescence detection. Journal of Pharmaceutical and Biomedical Analysis 2004; 35: 937-942.
11. US DHHS, FDA and CDER. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine, 2001. Available at: www/fda.gov/ cder/guidance/index.htm (accessed 29 June 2009).
12. Viswanathan CT, Bansal S, Booth B, DeStefano AJ, Rose MJ, Sailstad J, Shah VP, Skelly JP, Swann PG and Weiner R. Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. Pharmaceutical Research 2007; 24: 1962-1973.