Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam

Pharmacoepidemiology and Drug Safety

Volumn 19, Issue 2, 2010, Pages 175-182

  Gidai, János ^a   Ács, Nándor ^a   Bánhidy, Ferenc ^a   Czeizel, Andrew E ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b FOUNDATION FOR THE COMMUNITY CONTROL OF HEREDITARY DISEASES   (Hungary)

Author keywords

Congenital abnormalities; Nitrazepam; Pregnancy age at delivery; Suicide attempt during pregnancy

Indexed keywords

DIAZEPAM; MEGADON; NITRAZEPAM; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIRTH WEIGHT; CHILD; COMPARATIVE ANATOMY; CONGENITAL DISORDER; CONTROLLED STUDY; DELIVERY; DRUG INTOXICATION; DRUG MEGADOSE; FEMALE; HOSPITAL ADMISSION; HUMAN; LIVE BIRTH; MAJOR CLINICAL STUDY; NEWBORN; PREGNANCY; PRIORITY JOURNAL; SELF POISONING; SUICIDE ATTEMPT; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; ANTI-ANXIETY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEVELOPMENT; HUMANS; INFANT; MALE; MODELS, BIOLOGICAL; NITRAZEPAM; PREGNANCY; SUICIDE, ATTEMPTED;

EID: 76149097187     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.1885     Document Type: Article

References (30)

1. Czeizel AE, Gidai J, Petik D, Timmermann G, Puhó HE. Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugs. Toxic Indust Health 2008; 24: 11-28.
2. Skegg K. Self-harm. Lancet 2005; 366: 1471-1483.
3. Schmidtke A, Bille-Brahe U, DeLeo D. Attempted suicide in Europe: rates, trends and sociodemographic characteristics of suicide attempters during the period 1989-1992. Acta Psychiatr Scand 1996; 93: 327-338.
4. Hawton K, Rodham K, Evans E, Weatherall R. Deliberate self-harm in adolescents: self report survey in schools in England. Br Med J 2002; 32: 1207-1211.
5. Bertolote LM, Fleischmann A. Suicidal behaviour prevention WHO perspectives on research. Am J Med Genet (Semin Med Genet) 2005; 133: 8-12.
6. Czeizel AE. The estimation of human teratogenic/fetotoxic risk of exposures to drugs on the basis of Hungarian experience: a critical evaluation of clinical and epidemiological models of human teratology. Expert Opin Drug Saf 2009; 8: 283-303.
7. Erös E, Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J. A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolam and clonazepam treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol 2002; 101: 147-154.
8. Czeizel AE. Budapest registry of self-poisoned patients. Mutat Res 1994; 312: 157-163.
9. Czeizel AE, Szentesi I, Szekeres I, Glauber A, Bucski P, Molnár G. Pregnancy outcome and health conditions of offspring of self-poisoned pregnant women. Acta Paediatr Hung 1984; 5: 209-236.
10. Czeizel AE, Szentesi I, Szekeres I, Molnár G, Glauber A, Bucski P. A study of adverse effects on the progeny after intoxication during pregnancy. Arch Toxicol 1988; 62: 1-7.
11. Czeizel AE, Lendvay A. Attempted suicide and pregnancy. Am J Obstet Gynecol 1989; 161: 497.
12. Lendvay A, Czeizel AE. A behavioural teratologic study on offspring of self -poisoned pregnant women. Acta Paediatr Hung 1992; 32: 347-369.
13. Czeizel AE, Tomcsik J, Tímár L. Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstet Gynecol 1997; 90: 195-201.
14. Vitéz M, Korányi G, Gönczy E, Rudas T, Czeizel AE. A semiquantitative score system for epidemiological studies of fetal alcohol syndrome. Am J Epidemiol 1984; 119: 301-308.
15. Czeizel AE. Specified critical period of different congenital abnormalities: a new approach for human teratological studies. Cong Anom (Kyoto) 2008; 48: 103-109.
16. Czeizel AE, Rockenbauer M, Siffel C, Varga E. Description and mission evaluation of the Hungarian case-control surveillance of congenital abnormalities, 1980-1996. Teratology 2001; 63: 176-185.
17. Hojer J, Baehrendtz S, Gustafsson L. Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14-year period. J Intern Med 1989; 226: 117-122.
18. McElhatton PR. The effects of benzodiazepines use during pregnancy and lactation. Reprod Toxicol 1994; 8: 461-475.
19. Jorgensen NP, Thurmann-Nielsen E, Walstad RA. Pharmacokinetics and distribution of diazepam and oxazepam in early pregnancy. Acta Obstet Gynecol Scand 1988; 67: 493-497.
20. USP DI. Benzodiazepine. In USP Dispensing Information, Vol. I. Drug Information for the Health Care Professional, 1996, (15th edn), US Pharmacopeial Convention: Rockville, MD, 1995; 460.
21. Kangas L, Kanto J, Erkkola R. Transfer of nitrazepam across the human placental Eur J Clin Pharmac. 1977; 12: 355-357.
22. Czeizel AE, Intocombining double acute accentdy Cs, Modell B. What proportions of congenital abnormalities can be prevented? Brit Med J 1993; 306: 499-503.
23. Czeizel AE, Gardonyi J. A family study of congenital inguinal hernia. Am J Med Genet 1979; 4: 305-313.
24. Bracken MB, Holford TR. Exposure of prescribed drugs in pregnancy and association with congenital malformations. Obstet Gynecol 1981; 5: 336-344.
25. Rosenberg L, Mitchell AA, Parsells JL, Pashayan H, Louik C, Shapiro S. Lack of correlation of oral clefts to diazepam use during pregnancy. N Engl J Med 1983; 309: 1282-1285.
26. Belenkaya TY, Wu Y, Tang X, et al. The Retromer complex influences Wnt secretion by recycling Wntless from endosomes to the Trans-Golgi network. Develop Cell 2008; 1: 120-131.
27. Yang P-T, Lorenowicz MJ, Silhankova MS, Coulreuse DYM, Betist MC, Korswagen HK. Wnt signalling requires Retromer-dependent recycling of MIG-14/Wntless in WNT-producing cells. Develop Cell 2008; 14: 140-147.
28. Takeno S, Nakagawa M, Sakai T. Teratogenic effects of nitrazepam in rats. Res Commun Chemical Pathol Pharmacol 1990; 69: 59-70. cit. Shepard TH, Lemire RJ. Catalog of Teratogenic Agents. (11th edn), Johns Hopkins Univ Press: Baltimore, 2004; p. 2134.
29. Saito H, Kobayashi H, Takemo S, Sakai T. Fetal toxicity of benzodiazepines in rats. Res Commun Chemical Pathol Pharmacol 1984; 46: 437-447 cit. Shepard TH, Lemire RJ. Catalog of Teratogenic Agents. (11th ed), Johns Hopkins Univ Press: Baltimore, 2004; p. 2134.
30. Czeizel AE, Petik D, Puhó E. Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Centr Eur J Publ Health 2004; 12: 179-183.