BRCA1/2 predictive testing and gender: Uptake, motivation and psychological characteristics

Genetic Counseling

Volumn 20, Issue 4, 2009, Pages 293-305

  Denayer, L ^a   Boogaerts, A ^a   Philippe, K ^a   Legius, E ^a   Evers Kiebooms, G ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

BRCA1; BRCA2; Gender; Offspring; Predictive testing; Psychology; Uptake

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SCREENING; COPING BEHAVIOR; DISTRESS SYNDROME; EARLY DIAGNOSIS; EDUCATIONAL STATUS; EMOTIONALITY; FEMALE; GENETIC COUNSELING; HEALTH CARE UTILIZATION; HELP SEEKING BEHAVIOR; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MASTECTOMY; MOTIVATION; MUTATIONAL ANALYSIS; OVARIECTOMY; OVARY CANCER; PREGNANCY; PROGENY; PSYCHOLOGICAL ASPECT; SEX DIFFERENCE; SIBLING; SOCIAL STATUS;

ADAPTATION, PSYCHOLOGICAL; ADOLESCENT; ADULT; AGED; BELGIUM; BREAST NEOPLASMS, MALE; FAMILY HEALTH; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC TESTING; HETEROZYGOTE DETECTION; HUMANS; MALE; MIDDLE AGED; MOTIVATION; PATIENT ACCEPTANCE OF HEALTH CARE; SEX FACTORS;

EID: 76049120566     PISSN: 10158146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. ARRINDELL W.A., ETTEMA J.H.: SCL-90 Handlei-ding bij een Multidimensionele Psychopathologie-indicator. Lisse, Swets & Zeitlinger, 1986.
2. BODD T.L., REICHELT J., HEIMDAL K., MØLLER P.: Uptake of BRCA1 genetic testing in adult sisters and daughters of known mutation carriers in Norway. J. Genet. Couns., 2003, 12, 405-417.
3. BOWEN D.J., BOURCIER E., PRESS N., LEWIS F.M., BURKE W.: Effects of individual and family functioning on interest in genetic testing. Community Genet., 2004, 7, 25-32.
4. BROOKS L., LENNARD F., SHENTON A., LALLOO F., AMBUS I., ARDERN-JONES A., BELK., R., KERR B., CRAUFURD D., EELES R., EVANS D.G.: BRCA 1/2 predictive testing: a study of uptake in two centres. Eur. J. Hum. Gen., 2004, 12, 654-662.
5. CLAES E., EVERS-KIEB00MS G., DENAYER L., DECRUYENAERE M., BOOGAERTS A., PHILIPPE K., EVERS-KIEBOOMS G., LEGIUS E.: Predictive genetic testing for hereditary breast and ovarian cancer: psychological distress and illness representations one year following disclosure. J. Genet. Couns., 2005, 14, 349-363.
6. CLAES E., EVERS-KIEBOOMS G., DENAYER L., DECRUYENAERE M., BOOGAERTS A., PHILIPPE K., EVERS-KIEBOOMS G., LEGIUS E.: Surveillance behavior and prophylactic surgery after predictive testing for hereditary breast/ovarian cancer. Behav. Med., 2005, 31, 93-105.
7. DALY P.A., NOLAN C., GREEN A., ORMISTON W., CODY N., MCDEVITT T., O'HICI B., BYRNE D., MCDERMOTT E., CARNEY D. N., O'HIGGINS N., BARTON D.E.: Predictive testing for BRCA1 and 2 mutations: a male contribution. Ann. Oncol., 2003, 14, 549-553.
8. DECRUYENAERE M., EVERS-KIEBOOMS G., DENAYER L., WELKENHUYSEN M., CLAES E., LEGIUS E., DEMYTTENAERE K.: Predictive testing for hereditary breast and ovarian cancer: a psychological framework for pre-test counselling. Eur. J. Hum. Genet., 2000, 8, 130-136.
9. DUDOK DE WIT A.C., TlBBEN A., FRETS P.G., MEIJERS-HEIJBOER E.J., DEVILEE P., NIERMEIJER M.F.: Males at-risk for the BRCA1-gene, the psychological impact. Psychooncology, 1996, 5, 251-257.
10. EVANS D.G.R., BINCHY A., SHENTON A., HOPWOOD P., CRAUFURD D.: Comparison of proactive and usual approaches to offering predictive testing for BRCA 1/2 mutations in unaffected relatives. Clin. Genet. 2009, 75, 124-132.
11. FINLAY E., STOPFER J.E., BURLINGAME E., GOLDFEDER EVANS K., NATHANSON K.L., WEBER B.L., ARMSTRONG K., REBBECK T.R., DOMCHEK S.M.: Factors determining dissemination of results and uptake of genetic testing in families with known BRCA 1/2 mutations. Genet. Test., 2008, 12, 81-91.
12. FOSTER C., EVANS D.G.R., EELES R., ECCLES D., ASHLEY S., BROOKS L., DAVIDSON R., MACKAY J., MORRISON P.J., WATSON M.: Predictive testing for BRCA 1/2: attributes, risk perception and management in a multi-centre clinical cohort. Br. J. Cancer, 2002, 86, 1209-1216.
13. HALLOWELL N., ARDERN-JONES A., EELES R., FOSTER C., LUCASSEN A., MOYNIHAN C., WATSON M.: Men's decision-making about predictive BRCA 1/2 testing: the role of family. J. Genet. Couns., 2005, 14, 207-217.
14. HOROWITZ M., WILNER N., ALVAREZ W.: Impact of Event Scale: a measure of subjective stress. Psychosom. Med., 1979, 41, 209-218.
15. KENNEDY R.D., QUINN J.E., JOHNSTON P.G., HARKIN D.P.: BRCA1: mechanisms of inactivation and implications for management of patients. The Lancet, 2002, 360, 1007-1014.
16. LIEDE A., METCALFE K., HANNA D., HOODFAR E., SNYDER C., DURHAM C. LYNCH H., NAROD S.: Evaluation of the needs of male carriers of mutations in BRCA1 or BRCA2 who have undergone genetic counselling. Am. J. Hum. Genet., 2000, 67, 1494-1504.
17. LIEDE A., KARLAN B.Y., NAROD S.A.: Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature. J. Clin. Oncol., 2004, 22, 735-742.
18. LODDER L., FRETS P.G., TRIJSBURG R.W., TIBBEN A., MEIJERS-HEIJBOER E.J., DUIVEN-VOORDEN H.J., WAGNER A., VAN DER MEER C.A., DEVILEE P., CORNELISSE C.J., NIERMEIJER M.F.: Men at risk of being a mutation carrier for hereditary breast/ovarian cancer: an exploration of attitudes and psychological functioning during genetic testing. Eur. J. Hum. Gen., 2001, 9, 492-500.
19. MATUD M.P.: Gender differences in stress and coping styles. Personality and Individual Differences, 2004, 37, 1401-1415.
20. McALLISTER M.F., EVANS D.G., ORMISTON W., DALY P.: Men in breast cancer families: a preliminary qualitative study of awareness and experience. J. Med. Genet., 1998, 35, 739-744.
21. MEIJERS-HEIJBOER E.J., VERHOOG L.C., BREKELMANS C.T., SEYNAEVE C., TILANUSLINTHORST M.M., WAGNER A., DUKEL L., DEVILEE P., VAN DEN OUWELAND A.M., VAN GEEL A.N., KLIJN J.G.: Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation. The Lancet, 2000, 355, 2015-20.
22. MEISER B.: Psychological impact of genetic testing for cancer susceptibility: an update of the literature. Psychooncology, 2005, 14, 1060-1074.
23. MEISER B., GAFF C., JULIAN-REYNIER C., BIESECKER B.B., ESPLEN M.J., VODERMAIER A., TIBBEN A.: International perspectives on genetic counseling and testing for breast cancer risk. Breast. Dis., 2006, 2007, 27, 109-125.
24. REICHELT J.G., DAHL A.A., HEIMDAL K., MOLLER P.: Uptake of genetic testing and pre-test levels of mental distress in Norwegian families with known BRCA1 mutations. Dis. Markers, 1999,15, 139-143.
25. ROBICHAUD M., DUGAS M.J., CONWAY M.: Gender differences in worry and associated cognitive-behavioral variables. J. Anxiety Disord., 2003, 17, 501-516.
26. ROPKA M.E., WENZEL J., PHILLIPS E., SIADATY M., PHILBRICK J.T.: Uptake rates for breast cancer genetic testing: a systematic review. Cancer Epidemiol. Biomarkers Prev, 2006, 15, 840-855.
27. SCHREURS P.J., VAN DE WILLIGE G., TELLEGEN B., BROSSCHOT J.F.: De Utrechtse Copinglijst. Omgaan met Problemen en Gebeurtenissen. Lisse, Swets & Zeitlinger, 1988.
28. SIEGEL S., CASTELLAN N.J: Nonparametric Statistics for the Behavioral Sciences. New York, Mc Graw-Hill Book Company, 1988.