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Volumn 125, Issue 2, 2010, Pages

Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants

Author keywords

Antiretroviral treatment; Bayley scales; Low birth weight; Maternal health; Mental development; Motor development

Indexed keywords

ANTIRETROVIRUS AGENT; ILLICIT DRUG; LAMIVUDINE; ZIDOVUDINE;

EID: 76049110308     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2009-1112     Document Type: Article
Times cited : (72)

References (44)
  • 1
    • 0028003766 scopus 로고
    • Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group
    • Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994;331(18):1173-1180
    • (1994) N Engl J Med , vol.331 , Issue.18 , pp. 1173-1180
    • Connor, E.M.1    Sperling, R.S.2    Gelber, R.3
  • 2
    • 0036239507 scopus 로고    scopus 로고
    • Combination antiretroviral strategies for the treatment of pregnant HIV-1 infected women and prevention of perinatal HIV-1 transmission
    • Cooper ER, Charurat M, Mofenson L, et al. Combination antiretroviral strategies for the treatment of pregnant HIV-1 infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr. 2002;29(5):484-494
    • (2002) J Acquir Immune Defic Syndr , vol.29 , Issue.5 , pp. 484-494
    • Cooper, E.R.1    Charurat, M.2    Mofenson, L.3
  • 3
    • 0035865870 scopus 로고    scopus 로고
    • Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads < 1000 copies/ml
    • Ioannidis JP, Abrams EJ, Ammann A, et al. Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads < 1000 copies/ml. J Infect Dis. 2001;183(4):539 -545
    • (2001) J Infect Dis , vol.183 , Issue.4 , pp. 539-545
    • Ioannidis, J.P.1    Abrams, E.J.2    Ammann, A.3
  • 4
    • 34247872923 scopus 로고    scopus 로고
    • Systematic review of the efficacy of antiretroviral therapies for reducing the risk of mother-to-child transmission of HIV infection
    • Suksomboon N, Poolsup N, Ket-aim S. Systematic review of the efficacy of antiretroviral therapies for reducing the risk of mother-to-child transmission of HIV infection. J Clin Pharm Ther. 2007;32(3):293-311
    • (2007) J Clin Pharm Ther , vol.32 , Issue.3 , pp. 293-311
    • Suksomboon, N.1    Poolsup, N.2    Ket-aim, S.3
  • 5
    • 76049130099 scopus 로고    scopus 로고
    • Perinatal HIV Guidelines Working Group. Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1 infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. April 29, 2009; pp. 1-90. Available at http://aidsinfo.nih. gov/ContentFiles/PerinatalGL.pdf. Accessed November 23, 2009.
    • Perinatal HIV Guidelines Working Group. Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1 infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. April 29, 2009; pp. 1-90. Available at http://aidsinfo.nih. gov/ContentFiles/PerinatalGL.pdf. Accessed November 23, 2009.
  • 6
    • 85033050931 scopus 로고    scopus 로고
    • Nonclinical toxicology studies with zidovudine: Genetic toxicity and carcinogenicity bioassays in mice and rates
    • Ayers KM, Clive D, Tucker WE Jr, Haijian G, de Miranda P. Nonclinical toxicology studies with zidovudine: genetic toxicity and carcinogenicity bioassays in mice and rates. Fundam Appl Toxicol. 1996;32(2):148-158
    • (1996) Fundam Appl Toxicol , vol.32 , Issue.2 , pp. 148-158
    • Ayers, K.M.1    Clive, D.2    Tucker Jr, W.E.3    Haijian, G.4    de Miranda, P.5
  • 7
    • 0030715604 scopus 로고    scopus 로고
    • Transplacental effects of 3′-azido-2′,3′-dideoxythymidine (AZT): Tumorigenicity in mice and genotoxicity in mice and monkeys
    • Olivero OA, Anderson LM, Diwan BA, et al. Transplacental effects of 3′-azido-2′,3′-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys. J Natl Cancer Inst. 1997;89(21):1602-1608
    • (1997) J Natl Cancer Inst , vol.89 , Issue.21 , pp. 1602-1608
    • Olivero, O.A.1    Anderson, L.M.2    Diwan, B.A.3
  • 8
    • 4143074797 scopus 로고    scopus 로고
    • Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs
    • Poirier MC, Olivero OA, Walker DM, Walker VE. Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs. Toxicol Appl Pharmacol. 2004;199(2):151-161
    • (2004) Toxicol Appl Pharmacol , vol.199 , Issue.2 , pp. 151-161
    • Poirier, M.C.1    Olivero, O.A.2    Walker, D.M.3    Walker, V.E.4
  • 9
    • 0033550472 scopus 로고    scopus 로고
    • Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams
    • Culnane M, Fowler MG, Lee SS, et al. Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams. JAMA. 1999;281(2):151-157
    • (1999) JAMA , vol.281 , Issue.2 , pp. 151-157
    • Culnane, M.1    Fowler, M.G.2    Lee, S.S.3
  • 10
    • 33947275035 scopus 로고    scopus 로고
    • Safety of agents used to prevent mother-to-child transmission of HIV: Is there any cause for concern?
    • Thorne C, Newell ML. Safety of agents used to prevent mother-to-child transmission of HIV: is there any cause for concern? Drug Saf. 2007;30(30):203-213
    • (2007) Drug Saf , vol.30 , Issue.30 , pp. 203-213
    • Thorne, C.1    Newell, M.L.2
  • 11
    • 0037379462 scopus 로고    scopus 로고
    • Exposure to antiretroviral therapy in utero or early life: The health of uninfected children born to HIV-infected women
    • European Collaborative Study
    • European Collaborative Study. Exposure to antiretroviral therapy in utero or early life: the health of uninfected children born to HIV-infected women. J Acquir Immune Defic Syndr. 2003;32(4):380 -387
    • (2003) J Acquir Immune Defic Syndr , vol.32 , Issue.4 , pp. 380-387
  • 12
    • 7344221468 scopus 로고    scopus 로고
    • Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 study
    • Sperling RS, Shapiro DE, McSherry GD, et al. Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 study. AIDS. 1998;12(14):1805-1813
    • (1998) AIDS , vol.12 , Issue.14 , pp. 1805-1813
    • Sperling, R.S.1    Shapiro, D.E.2    McSherry, G.D.3
  • 13
    • 0033560997 scopus 로고    scopus 로고
    • Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine
    • Hanson IC, Antonelli A, Sperling RS, et al. Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20(5):463- 467
    • (1999) J Acquir Immune Defic Syndr Hum Retrovirol , vol.20 , Issue.5 , pp. 463-467
    • Hanson, I.C.1    Antonelli, A.2    Sperling, R.S.3
  • 14
    • 33646797733 scopus 로고    scopus 로고
    • In utero nucleoside reverse transcriptase inhibitor exposure and cancer in HIV-uninfected children: An update from the pediatric AIDS clinical trials group 219 and 219C cohorts
    • Brogly S, Williams P, Seage GR, et al. In utero nucleoside reverse transcriptase inhibitor exposure and cancer in HIV-uninfected children: an update from the pediatric AIDS clinical trials group 219 and 219C cohorts. J Acquir Immune Defic Syndr. 2006;41(4): 535-536
    • (2006) J Acquir Immune Defic Syndr , vol.41 , Issue.4 , pp. 535-536
    • Brogly, S.1    Williams, P.2    Seage, G.R.3
  • 15
    • 17144457068 scopus 로고    scopus 로고
    • Height, weight, and growth in children born to mothers with HIV-1 infection in Europe
    • The European Collaborative Study, Available at
    • The European Collaborative Study. Height, weight, and growth in children born to mothers with HIV-1 infection in Europe. Pediatrics. 2003;111(1). Available at: www.pediatrics.org/cgi/content/full/111/1/e52
    • (2003) Pediatrics , vol.111 , Issue.1
  • 16
    • 0030026873 scopus 로고    scopus 로고
    • Natural history of somatic growth in infants born to women infected by human immunodeficiency virus
    • Moye J, Rich KC, Kalish LA. Natural history of somatic growth in infants born to women infected by human immunodeficiency virus. J Pediatr. 1996;128(1):58-69
    • (1996) J Pediatr , vol.128 , Issue.1 , pp. 58-69
    • Moye, J.1    Rich, K.C.2    Kalish, L.A.3
  • 17
    • 33749596526 scopus 로고    scopus 로고
    • Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: An analysis of the Women and Infants Transmission Study
    • Pacheco SE, McIntosh K, Lu M, Mofenson LM, et al. Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: an analysis of the Women and Infants Transmission Study. J Infect Dis. 2006;194(8):1089 -1097
    • (2006) J Infect Dis , vol.194 , Issue.8 , pp. 1089-1097
    • Pacheco, S.E.1    McIntosh, K.2    Lu, M.3    Mofenson, L.M.4
  • 18
    • 0142062006 scopus 로고    scopus 로고
    • Enquete Perinatale Francaise Study Group. Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants
    • Le Chenadec J, Mayaux M-J, Giuhenneuc-Jouyaux C, Blanche S, Enquete Perinatale Francaise Study Group. Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants. AIDS. 2003;17(14):2053-2061
    • (2003) AIDS , vol.17 , Issue.14 , pp. 2053-2061
    • Le Chenadec, J.1    Mayaux, M.-J.2    Giuhenneuc-Jouyaux, C.3    Blanche, S.4
  • 19
    • 28744449446 scopus 로고    scopus 로고
    • Haematological parameters of HIV-1-uninfected infants born to HIV-1-infected mothers
    • Bunders MJ, Bekker V, Scherpbier HJ, et al. Haematological parameters of HIV-1-uninfected infants born to HIV-1-infected mothers. Acta Paediatr. 2005;94(11):1571-1577
    • (2005) Acta Paediatr , vol.94 , Issue.11 , pp. 1571-1577
    • Bunders, M.J.1    Bekker, V.2    Scherpbier, H.J.3
  • 20
    • 7744228997 scopus 로고    scopus 로고
    • Levels and patterns of neutrophil cell counts over the first 8 years of life in children of HIV-1 infected mothers
    • European Collaborative Study
    • European Collaborative Study. Levels and patterns of neutrophil cell counts over the first 8 years of life in children of HIV-1 infected mothers. AIDS. 2004;18(15):2009 -2017
    • (2004) AIDS , vol.18 , Issue.15 , pp. 2009-2017
  • 21
    • 0034319154 scopus 로고    scopus 로고
    • absence of clear evidence for mitochondrial disease in children who died before 5 years of age in five United States cohorts
    • Nucleoside exposure in the children of HIV-infected women receiving antiretroviral drugs
    • Nucleoside exposure in the children of HIV-infected women receiving antiretroviral drugs: absence of clear evidence for mitochondrial disease in children who died before 5 years of age in five United States cohorts. J Acquir Immune Defic Syndr. 2000;25(3):261-268
    • (2000) J Acquir Immune Defic Syndr , vol.25 , Issue.3 , pp. 261-268
  • 22
    • 0033637597 scopus 로고    scopus 로고
    • Drug safety during pregnancy and in infants: Lack of mortality related to mitochondrial dysfunction among perinatally HIV-exposed children in pediatric HIV surveillance
    • Lindegren ML, Rhodes PH, Gordon L, et al. Drug safety during pregnancy and in infants: lack of mortality related to mitochondrial dysfunction among perinatally HIV-exposed children in pediatric HIV surveillance. Ann N Y Acad Sci. 2000;918:222-235
    • (2000) Ann N Y Acad Sci , vol.918 , pp. 222-235
    • Lindegren, M.L.1    Rhodes, P.H.2    Gordon, L.3
  • 23
    • 0036603054 scopus 로고    scopus 로고
    • Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants
    • Mofenson LM, Muderi P. Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants. J Acquir Immune Defic Syndr. 2002;30(2):200 -215
    • (2002) J Acquir Immune Defic Syndr , vol.30 , Issue.2 , pp. 200-215
    • Mofenson, L.M.1    Muderi, P.2
  • 24
    • 0033638030 scopus 로고    scopus 로고
    • Lack of evidence of mitochondrial dysfunction in the offspring of HIV-infected women: Retrospective review of perinatal exposure to antiretroviral drugs in the Perinatal AIDS Collaborative Transmission Study
    • Bulterys M, Nesheim S, Abrams EJ, et al. Lack of evidence of mitochondrial dysfunction in the offspring of HIV-infected women: retrospective review of perinatal exposure to antiretroviral drugs in the Perinatal AIDS Collaborative Transmission Study. Ann N Y Acad Sci. 2000;918:212-221
    • (2000) Ann N Y Acad Sci , vol.918 , pp. 212-221
    • Bulterys, M.1    Nesheim, S.2    Abrams, E.J.3
  • 25
    • 0033635635 scopus 로고    scopus 로고
    • Lack of definitive severe mitochondrial signs and symptoms among deceased HIV-uninfected and HIV-indeterminate children < 5 years of age
    • Dominguez K, Bertoli J, Fowler M, et al. Lack of definitive severe mitochondrial signs and symptoms among deceased HIV-uninfected and HIV-indeterminate children < 5 years of age. Ann N Y Acad Sci. 2000;918:236-246
    • (2000) Ann N Y Acad Sci , vol.918 , pp. 236-246
    • Dominguez, K.1    Bertoli, J.2    Fowler, M.3
  • 26
    • 0034648743 scopus 로고    scopus 로고
    • Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group
    • Lipshultz SE, Easley KA, Orav EJ, et al. Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med. 2000;343(11):759-766
    • (2000) N Engl J Med , vol.343 , Issue.11 , pp. 759-766
    • Lipshultz, S.E.1    Easley, K.A.2    Orav, E.J.3
  • 27
    • 0033604060 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
    • Blanche S, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet. 1999;354(9184):1084-1089
    • (1999) Lancet , vol.354 , Issue.9184 , pp. 1084-1089
    • Blanche, S.1    Tardieu, M.2    Rustin, P.3
  • 28
    • 0042232027 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: Clinical screening in a large prospective cohort
    • Barret B, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: clinical screening in a large prospective cohort. AIDS. 2003;17(12):1769-1785
    • (2003) AIDS , vol.17 , Issue.12 , pp. 1769-1785
    • Barret, B.1    Tardieu, M.2    Rustin, P.3
  • 29
    • 34247609876 scopus 로고    scopus 로고
    • In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children
    • Brogly SB, Ylitalo N, Mofenson LM, et al. In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children. AIDS. 2007;21(8):929-938
    • (2007) AIDS , vol.21 , Issue.8 , pp. 929-938
    • Brogly, S.B.1    Ylitalo, N.2    Mofenson, L.M.3
  • 30
    • 0038078685 scopus 로고    scopus 로고
    • Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers
    • Poirier MC, Divi RL, Al-Harthi L, et al. Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers. J Acquir Immune Defic Syndr. 2003;33(2):175-183
    • (2003) J Acquir Immune Defic Syndr , vol.33 , Issue.2 , pp. 175-183
    • Poirier, M.C.1    Divi, R.L.2    Al-Harthi, L.3
  • 31
    • 0034242893 scopus 로고    scopus 로고
    • Early cognitive and motor development among infants born to women infected with human immunodeficiency virus. Women and Infants Transmission Study Group
    • Available at
    • Chase C, Ware J, Hittelman J, Blasini I, et al. Early cognitive and motor development among infants born to women infected with human immunodeficiency virus. Women and Infants Transmission Study Group. Pediatrics. 2000;106(2). Available at: www.pediatrics.org/cgi/content/full/106/2/e25
    • (2000) Pediatrics , vol.106 , Issue.2
    • Chase, C.1    Ware, J.2    Hittelman, J.3    Blasini, I.4
  • 32
    • 33947096362 scopus 로고    scopus 로고
    • PACTG 219C Study Team. Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy
    • Available at
    • Lindsey JC, Malee KM, Brouwers P, Hughes MD, PACTG 219C Study Team. Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy. Pediatrics. 2007;119(3). Available at: www.pediatrics.org/cgi/content/full/119/3/e681
    • (2007) Pediatrics , vol.119 , Issue.3
    • Lindsey, J.C.1    Malee, K.M.2    Brouwers, P.3    Hughes, M.D.4
  • 33
    • 33750113221 scopus 로고    scopus 로고
    • A prospective controlled study of neurodevelopment in HIV-uninfected children exposed to combination antiretroviral drugs in pregnancy
    • Available at
    • Alimenti A, Forbes JC, Oberlander TF, et al. A prospective controlled study of neurodevelopment in HIV-uninfected children exposed to combination antiretroviral drugs in pregnancy. Pediatrics. 2006;118(4). Available at: www.pediatrics.org/cgi/content/full/118/4/e1139
    • (2006) Pediatrics , vol.118 , Issue.4
    • Alimenti, A.1    Forbes, J.C.2    Oberlander, T.F.3
  • 34
    • 0035936007 scopus 로고    scopus 로고
    • Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1
    • Gortmaker S, Hughes M, Cervia J, et al. Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1. N Engl J Med. 2001;345(21):1522-1528
    • (2001) N Engl J Med , vol.345 , Issue.21 , pp. 1522-1528
    • Gortmaker, S.1    Hughes, M.2    Cervia, J.3
  • 35
    • 33746100664 scopus 로고    scopus 로고
    • Incidence of opportunistic and other infections in HIV-infected children in the HAART era
    • Gona P, van Dyke R, Williams PL, et al. Incidence of opportunistic and other infections in HIV-infected children in the HAART era. JAMA. 2006;296(3):292-300
    • (2006) JAMA , vol.296 , Issue.3 , pp. 292-300
    • Gona, P.1    van Dyke, R.2    Williams, P.L.3
  • 38
    • 0142052969 scopus 로고    scopus 로고
    • Developmental outcome of drug-exposed children through 30 months: A comparison of Bayley and Bayley-II
    • Schuler ME, Nair P, Harrington D. Developmental outcome of drug-exposed children through 30 months: a comparison of Bayley and Bayley-II. Psychol Assess. 2003;15(3):435-438
    • (2003) Psychol Assess , vol.15 , Issue.3 , pp. 435-438
    • Schuler, M.E.1    Nair, P.2    Harrington, D.3
  • 39
    • 18244408516 scopus 로고    scopus 로고
    • Antiretroviral treatment in pediatric HIV in the United States: From clinical trials to clinical practice
    • Brogly S, Williams P, Seage GR III, et al. Antiretroviral treatment in pediatric HIV in the United States: from clinical trials to clinical practice. JAMA. 2005;293(18):2213-2220
    • (2005) JAMA , vol.293 , Issue.18 , pp. 2213-2220
    • Brogly, S.1    Williams, P.2    Seage III, G.R.3
  • 40
    • 0035940573 scopus 로고    scopus 로고
    • Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women
    • Macmillan C, Magder LS, Brouwers P, et al. Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women. Neurology. 2001;57(8):1402-1411
    • (2001) Neurology , vol.57 , Issue.8 , pp. 1402-1411
    • Macmillan, C.1    Magder, L.S.2    Brouwers, P.3
  • 41
    • 0027376087 scopus 로고
    • Maternal drug use in perinatal HIV studies: The Women and Infants Transmission Study
    • Rodriguez EM, Mendez H, Rich K, et al. Maternal drug use in perinatal HIV studies: the Women and Infants Transmission Study. Ann N Y Acad Sci. 1993;693:245-248
    • (1993) Ann N Y Acad Sci , vol.693 , pp. 245-248
    • Rodriguez, E.M.1    Mendez, H.2    Rich, K.3
  • 42
    • 0037313569 scopus 로고    scopus 로고
    • High rates of behavioral problems in perinatally HIV-infected children are not linked to HIV disease
    • Mellins CA, Smith R, O'Driscoll P, et al. High rates of behavioral problems in perinatally HIV-infected children are not linked to HIV disease. Pediatrics. 2003;111(2):384-393
    • (2003) Pediatrics , vol.111 , Issue.2 , pp. 384-393
    • Mellins, C.A.1    Smith, R.2    O'Driscoll, P.3
  • 43
    • 40449083885 scopus 로고    scopus 로고
    • Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets
    • Mercier F, Boulassel MR, Yassine-Diab B, et al. Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets. Clin Exp Immunol. 2008;152(1):72-80
    • (2008) Clin Exp Immunol , vol.152 , Issue.1 , pp. 72-80
    • Mercier, F.1    Boulassel, M.R.2    Yassine-Diab, B.3
  • 44
    • 34247467969 scopus 로고    scopus 로고
    • Challenges in using observational studies to evaluate adverse effects of treatment
    • Hughes MD, Williams PL. Challenges in using observational studies to evaluate adverse effects of treatment. N Engl J Med. 2007;356(17):1705- 1707
    • (2007) N Engl J Med , vol.356 , Issue.17 , pp. 1705-1707
    • Hughes, M.D.1    Williams, P.L.2


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