Occupational pesticides exposure of sprayers of grape gardens in western maharashtra (india): Effects on liver and kidney function

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 20, Issue 4, 2009, Pages 335-356

  Patil, Jyotsna A ^a   Patil, Arun J ^a   Sontakke, Ajit V ^a   Govindwar, Sanjay P ^b  

^a KRISHNA INSTITUTE OF MEDICAL SCIENCES   (India)

^b SHIVAJI UNIVERSITY   (India)

Author keywords

acetyl Cholinesterase; C reactive protein; hematologic parameters

Indexed keywords

ACETYLCHOLINESTERASE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; GLOBULIN; GLUCOSE; PESTICIDE; UREA;

ABSORPTION; ADULT; AGRICULTURAL WORKER; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; ERYTHROCYTE COUNT; GLUCOSE BLOOD LEVEL; GRAPE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; INDIA; KIDNEY FUNCTION; LEUKOCYTE; LEUKOCYTE COUNT; LIVER FUNCTION; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; NEPHROTOXICITY; OCCUPATIONAL EXPOSURE; PROTEIN BLOOD LEVEL; UREA BLOOD LEVEL; VENOUS BLOOD;

ADULT; AGRICULTURAL WORKERS' DISEASES; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; C-REACTIVE PROTEIN; HEMOGLOBINS; HUMANS; KIDNEY; LIVER; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PESTICIDES; VITIS;

EID: 76049109956     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.2009.20.4.335     Document Type: Article

References (86)

1. Glotfelty, DE. Pesticides in fog. Nature 1987:325:602-5.
2. Edwards, CA. Agrochemicals as environmental pollutants. In: van Hofsten, B & Ekstorm, G., ed. Control of pesticide application and residues in food. A guide and directory 1986, Uppsala, Swedish Science Press, 1986:1–19.
3. UNEP/FAO/WHO. Guidelines for predicting dietary intake of pesticide residues. Geneva, 1989.
4. Wolfe, HR. Durham, WF, Armstrong, JF. Exposure of workers to pesticides. Arch. Environ. Health 1967;14:622-33.
5. MacCollom, GB, Currier, WW, Baumann, GL. Drift comparisons between aerial and ground orchard application. J Econ Entomol 1986; 79:459-64.
6. World Health Organization. Environmental health criteria, No. 130, Endrin. Geneva: WHO, 1992.
7. World Health Organization Environmental health criteria, No. 145, Methyl Parathion. Geneva: WHO, 1993.
8. Patil, JA, Patil, AJ, Govindwar, SP. Biochemical effects of various pesticides on sprayers of grape gardens. Indian J Clin Biochem 2003;18:16–22.
9. Declaration of Helsinki. 1964 Amended by World Medical Assembly, Venice, Italy, 1983. 1996;31370:1448-9.
10. Knedel, B, Boettger, R, Klin, W. 1967 45. 325. Arbeitsgruppe enzyme der Deutschon Gesellschall fur, Klinische Chemie 1989 Mitt Dtsch Ges Klin Chemi Ps 20. 123-4.
11. Anderson, HC, McCarthy, M. Determination of C-reactive protein in the blood as a measure of the activity of the disease in acute rheumatic fever. Am J Med 1950;8:445-55.
12. Lothar, T. Clinical Laboratory Diagnostics, 1st Ed., Tlie Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology. Scand J Clin Lab Invest 1974;33:291.
13. Henry, RJ, Cannon, DC, Winkelman, JW. Method for increasing shelflite of a serum conjugated bilirubin reference composition and composition produced thereby. Clinical Chemistry, Principles and Techniques, Second Ed., New York, NY, USA: Harper Row Publishers, 1974; 1038-70.
14. Doumas, BT, Watson, WA, Biggs, HG. Albumin standards and the measurement of serum albumin with bromocresol green. Clin Chim Acta 1971;311:87–96.
15. Varely, H. Practical clinical Biochemistry Vol.1, Fifth edition, 1980; 1012.
16. Varley, H. Practical Clinical Biochemistry, Fourth Edition, 1975;453.
17. Kassirer, JP. Clinical evaluation of kidney function—Glomerular function. New Eng J Med 1971;285:385-9.
18. Larsen, K. Creatinine assay by a reaction-kinetic approach. Clin Chem Acta 1972;41:209-17.
19. Trinder, P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969;6, 24-7.
20. Young, DS, Pestaner, LC, Gibberman, V. Effects of drugs on clinical laboratory tests. Clin Chem 1975;21:1D–432D.
21. Tarbutton, PN, Gunter, CR. Enzymatic determination of total cholesterol in serum. Clin Chem 1974;20:724-5.
22. Schmidt-Kehl, L. Blood changes in chronic lead poisoning. Archiv Fuer Hygiene 1927;98:1–22.
23. Costa, LG. Interaction of neurotoxicants with neurotransmitters system. Toxicology 1988;49:359-66.
24. Avashia, BH. Is Carbaryl safe as its reputation, Letter to the Editor. Am JMed 1987;83:1168-9.
25. Kummer, R, Van Sittert, NJ. Field studies on health effects from the application of two OP insecticide formulations by handheld ULV to cotton. Toxicol Lett 1986;33:7–24.
26. European Centre for Ecotoxicology and toxicology of chemicals (ECETOC). Evaluation of the neurotoxic potential of chemicals. Brussels: ECETOC Monograph No. 18, 1992.
27. European Centre for Ecotoxicology and toxicology of chemicals ECETOC. OP pesticides and long-term effects on the nervous system. Brussels: ECETOC Technical Report No. 75, 1998.
28. Maxwell, DM, Lenz, DE, Croff, WA, Kaminskis, A, Froehlich, HL. The effects of blood flow & detoxification on in vivo Cholinesterase inhibition by soman in rats. Toxicol Appl Pharmacol 1987;88:66–76.
29. Padilla, S, Wilson, VZ, Bushnell, PJ. Studies on the correlation between blood Cholinesterase inhibition and tissue inhibition in pesticide treated rats. Toxicology 1994;92:11–25.
30. Meena, K, Gupta, PK, Bawa, SR. Endrin induced toxicity in normal and irradiated rats. Environ Res 1978;16:373-82.
31. Bushnell, P, Padilla, S, Ward, T, Pope, C, Oiszyk, V. Behavioral and nerochemical changes in rats dose repeated with diisopropyl fluoro-phosphate DEP. J Pharmacol Exp Ther 1991;256:741-50.
32. Tendon, P, Padilla, S, Pope, CN, Tilson, HA. Fenthion produces a persistent decrease in muscarinic receptor function in the adult rat retina. Toxicol Appl Pharmacol 1994;125:271-80.
33. Ray, DE. Chronic effects of low-level exposure to anticholinesterases a mechanistic review. Toxicol Lett 1999;103:527-33.
34. Fukuto, TR. Mechanism of action of organophosphorous and carbamate insecticides. Environ Health Persp 1990;87:245-54.
35. O'Malley, M. Clinical evaluation of pesticides exposure and poisonings. Lancet 1997;349:1161-6.
36. Lockridge, O, Bartels, CF, Vaughan, TA. Complete amino acid sequence of human serum Cholinesterase. J Biol Chem 1987;262:549-57.
37. Loewenstein-Lichtenstein, Y, Schwarz, M, Glick, D, Norgaard-Pedersen, B, Zakut, H, Soreq, H. Genetic predisposition to adverse consequences of anti-cholinesterases in ‘atypical’ BCHE carriers. Nat Med 1995;1 (10):1082-5.
38. Anderson, HC, Mccarty, M. Determination of C-reactive protein in the blood as a measure of the activity of the disease in acute rheumatic fever. Am J Med. 1950 Apr;8(4):445-55.
39. stEd, 1998.
40. Allazov, S. The role of pesticides in occurrence of pathological changes in kidneys. UrologiaI Nefrologiia. 1994:4:42-4.
41. International Agency for Research on Cancer (lARC). Occupational exposures in insecticide application and some pesticide. In: IARC Monographs on the evaluation of the Carcinogenic Risk of Chemical to Humans. Vol 53, Lyon, France: IARC, 1991.
42. Gomes, J, Dawodu, AH, Lloyd, O, Revitt, DM, Anilal, SV. Hepatic injury and disturbed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides. Hum Exp Toxicol 1999; 18(1):33-7.
43. Kossamann, S, Magner-Krezel, Z. Biochemical indices of liver functions in workers from repair brigades in chemical plants in Jaworz. Medycyna Pracy 1992;43:505-8.
44. Kulkami, AP, Mehrota, KN. Effect of dieldrin and sumithion on the amino acid nitrogen and protein in the haemolymph of desert locust Shistocerca gregaria Forsk. Pestic Biochem Physiol 1973;3:420-34.
45. Michalek, JE, Ketchum, NS, Longnecker, MP. Serum dioxin and hepatic abnormalities in veterans of operation Ranch Hand. Ann Epidemiol 2001;11(5):304-11.
46. Kagan, J. Topical questions about the toxicology of phosphorganic insecticides. Emahrungsforschung 1971;14:503-4 [in Genman]
47. lllahi, A, Amin, N, Hashmi, AS. Nawaz, M, Naeemur, R. Incidence of endrin residues in Cucumber and it's effect on biological system. J Pak Med Assoc 1986;36:209-11.
48. Luckens, MM, Phelps, KI. Serum enzyme patterns in acute poisoning with organochlorine insecticides. J Pharm Sci 1969;58:569-72.
49. El-Demerdash, FM, Yousef, Ml, Elagamy, El. Influence of paraquat, glyphosate, and cadmium on the activity of some serum enzymes and protein electrophoretic behavior in vitro. J Environ Sci Health B 2001; 36(1);29–42.
50. Mostafa, lY, Zayed, SM, Farghaly, M, Mahdy, F. Bioavailability to rats and toxicity in mice of carbofuran residues bound to faba beans. J Environ Sci Health B 1992;274:399–405.
51. Manna, S, Bhattacharyya, D, Mandai, TK, Das, S. Repeated dose toxicity of deltamethrin in rats. Indian J Pharmacol 2005;37:160-4.
52. Piñeiro-Carrero, VM, Piñeiro, EO. Liver. Pediatrics 2004; 113(4 Suppl): 1097-106.
53. Ram, RN, Singh, SK. Carbofuran-induced histopathological and biochemical changes in liver of the teleost fish. Ecotoxicol Environ Saf 1988;16(3):194–201.
54. Bomhard, E, Loser, E, Schilde, B. [E605-Methyl] Methyl parathion chronic toxicological studies in rats 2 year feeding trial Wuppartal— Elberfeld Bayer AG. Institute of Toxicology. IPCS 1981; 145:155.
55. Schilde, B, Bomhard, E. E 605-methyl Methyl parathion supplementary histopathological test further to the 2 year feeding trials on rats Addendum to report No. 9889. Wuppertal-Elberfeld, Bayer A. G. Ins. of toxicology. Unpublished report No. 12559 submitted to WHO by Bayer AG. Leverkusen Germany, 1984.
56. Subbotina, SG, Belonozhko, GA. The effect of Sevin on the thermoresistance and fractionary protein content of blood serum. Gig Primen Toxicol Pestic Klin Otrav 1968;442-4.
57. Khan, DA, Shabbir, S, Majid, M, Naqvi, TA, Khan, FA. Risk assessment of pesticide exposure on health of Pakistani tobacco farmers. J Expo Sci Environ Epidemiol. 2009 Jun 17. [Epub ahead of print]
58. Zavodnik, IB, Lapshina, EA, Zavodnik, LB, Soszy?ski, M, Bartosz, G, Bryszewska, M. Hypochlorous acid-induced oxidative damage of human red blood cells: effects of tert-butyl hydroperoxide and nitrite on the HOCl reaction with erythrocytes. Bioelectrochemistry 2002;58(2):127-35.
59. Koryagin, AS, Krylova, EV, Luk'yanova, LD. Effect of ubiquinone-10 on the blood system in rats exposed to radiation. Bull Exp Biol Med 2002;133(5):562-4.
60. John, S, Kale, M, Rathore, N, Bhatnagar, D. Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes. J Nutr Biochem. 2001 Sep;12(9):500–504.
61. Kumar, SS, Sika, HC, Saxena, J, Zweig, G. Membrane damage in human erythrocyte caused by captan and captafol. Pest Biochem Physiol 1975;5(4):338-47.
62. Thapar, A, Sandhir, R, Kiran, R. Acephate induced oxidative damage in erythrocytes. Indian J Exp Biol. 2002;40(8):963-6.
63. Altuntas, I, Delibas, N, Sutcu, R. The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: Role of vitamin E and C. Hum Exp Toxicol 2002;21(12):681-5.
64. Varshneya, C, Singh, T, Sharma, LD, Bahga, HS, Garg, SK. Immunotoxic responses of Cypermethrin, a synthetic pyrethroid insecticide in rats. Indian J Physiol Pharmacol. 1992 Apr;36(2): 123-6.
65. Hayes, WJ Jr. Clinical handbook on economic poisons. Public Health Service Publication No. 476, Washington DC, 1963.
66. Kessler, H, Mracek, JF. Non-fetal accidental OP pesticide intoxication in seven inmates of a correctional institution. J Med Assoc State Ala 1973;42:775-81.
67. Kar, PR, Matin, M.A. Duration of Diazinon induced changes in the brain acetycholine of rats. Pharmacol Res Commun 1971;3:351-4.
68. Bruce, RB, Howard, JW, Elsea, JR. Pesticide toxicity, toxicity of 0,0-diethyl 0-(2-Isopropyl-6-methyI-4-pyrimidyl) phosphorothioate (diazinon). J Agric Food Chem 1955;3:1017-21.
69. Holmstedt, B. Pharmacology of OP Cholinesterase inhibitors. Pharmacol Rev 1959;11:569–688.
70. Dybing, E, Sognen, E. Hyperglycaemia in rats after diazinon and other Cholinesterase inhibitors. Acta Pharmacol Toxicol 1958;14:231-5.
71. Weiss, LR, Bryant, J, Pitzhugh, CG. Blood sugar levels following acute poisoning with parathion and sevin in three species. Toxicol Appl Pharmacol 1960;6:363-4.
72. Matin, MA, Husain, K. changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals. J Appl Toxicol. 1987;7(2): 131-4.
73. Namba, T, Nolte, CT, Jackrel, J, Grob, D. Poisoning due to organophosphate insecticides. Acute and chronic manifestations. Am J Med. 1971 Apr;50(4):475-92.
74. Sutherland, WH, Woodhouse, SP. Physical activity and plasma lipoprotein lipid concentrations in men. Atherosclerosis 1980;372:285-92.
75. Al-Qarawi, AA, Adam SE. Effects of malathion plus superphosphate or urea on Najdi sheep. Vet Hum Toxicol 2003;45(1):3–6.
76. stedition. The Royal Pharmaceutical Society, London, 1996.
77. Abend, Y, Goland, S, Evron, E, Sthoeger, ZM, Geltner, D. Acute renal failure complicating organophosphate intoxication. Ren Fail 1994; 16(3):415-7.
78. Benjamin, N, Kushwah, A, Sharma, RK, Katiyar, AK. Histopathological changes in liver, kidney and muscles of pesticides exposed malnourished and diabetic rats. Indian J Exp Biol 2006;44(3):228-32.
79. Bhatnagar, VK, Sharma, RP, Malviya, AN. Effects of pesticidal stress amongst pesticide factory workers in Agra, India. Public Health. 1980;94(6):375-8.
80. Desai, I.G. Biological monitoring of group of green house pesticide sprayers. Toxicol Lett 1986;33:91–101.
81. Ray, PK, Prasad, AK. Pollution and health, New Delhi; Wiley Eastern Ltd, 1992.
82. Bomhard, E, Loser, E, Schilde, B. [E605-Methyl] Methyl parathion chronic toxicological studies in rats 2 year feeding trial Wuppartal -Elberfeld Bayer AG. Institute of toxicology. IPCS 1981;145:155.
83. Daly, IWA. Evaluation report for USEPA of a two-year chronic feeding study of methyl parathion in rats. East Millstone, New Jersey, Biodynamics Inc. Unpublished report, submitted to WHO by Bayer AG Leverkusen, Germany, 1983.
84. Merchant, MA, Mod, DN. Acute and chronic effects of aspirin on hematological parameters and hepatic ferritin expression in mice. Indian J. Pharmacol 2004;36:226-30.
85. Gallicchio, VS, Casale, GP, Bartholomew, PM, Watts, TD. Altered colony-forming activities of bone marrow hematopoietic stem cells in mice following short-term in vivo exposure to parathion. Int J Cell Cloning 1987;53:231-41.
86. Wu, ML, Deng, JF. Acute hemolysis caused by incidental trichlorfon exposure. J Chin Med Assoc 2009;724:214-8.