5-Fluorouracil loaded guar gum microspheres for colon delivery: Preparation, characterization and in vitro release

Yaoxue Xuebao

Volumn 44, Issue 11, 2009, Pages 1278-1284

  Kaushik, Dinesh ^a   Sardana, Satish ^a   Mishra, D N ^b  

^a Hindu College   (India)

^b GURU JAMBHESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Biodegradable polymer; Colon delivery; Guar gum; In vitro release

Indexed keywords

FLUOROURACIL; GUAR GUM; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CECUM; COLON; COLORECTAL CANCER; CONTROLLED STUDY; DISPERSION; DRUG ANALYSIS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG RETENTION; DRUG SYNTHESIS; DRUG TARGETING; EMULSION; ENZYME INDUCTION; IN VITRO STUDY; INTESTINE FLUID; MALE; MICROSCOPY; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; RAT; SCANNING ELECTRON MICROSCOPY; SIMULATION; STOMACH JUICE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CECUM; COLON; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FLUOROURACIL; GALACTANS; MANNANS; MICROSPHERES; PARTICLE SIZE; PLANT GUMS; RATS;

EID: 76049100458     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Heidelberger C, Chaudhuri NK, Danneburg P. Fluorinated pyrimidine. A new class of tumor inhibitory compounds [J]. Nature, 1957, 179: 663-666.
2. Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems [J]. J Pharm Pharm Sci, 2003, 6: 33-66.
3. Wilding IR, Hardy JG, Sparrow RA, et al. In vivo evaluation of enteric coated naproxan tablets using gamma scintigraphy [J]. Pharm Res, 1992, 9: 1436-1441.
4. Khan MZ, Prebeg Z, Kurjakovic N. A pH dependent colon targeted oral drug delivery system using methacrylic acid copolymers I. Manipulation of drug release using Eudragit L100-55 and Eudragit S100 combinations [J]. J Control Release, 1999, 58: 215-222.
5. Lippold BH, Sutter BK, Lippold BC. Parameters controlling drug release from pellets coated with aqueous ethyl cellulose dispersions [J]. Int J Pharm, 1989,54: 15-25.
6. Ashford M, Fell JT, Attwood D, et al. An in vivo investigation into the suitability of pH-dependent polymers for colonic targeting [J]. Int J Pharm, 1993, 95: 193-199.
7. Van den Mooter G, Samyn C, Kinget R. Azo polymers for colon-specific drug delivery. Part II influence of the type of azo polymer on the degradation by intestinal microflora [J]. Int J Pharm, 1993, 97: 133-139.
8. Chourasia MK, Jain SK. Design and development of multi particulate system for targeted drug delivery to colon [J]. Drug Deliv, 2004, 11: 201-207.
9. Chourasia MK, Jain SK. Polysaccharides for colon targeted drug delivery [J]. Drug Deliv, 2004, 11: 129-148.
10. Gliko-Kabir I, Yagen B, Baluom M, et al. Phosphated cross-linked guar for colon-specific drug delivery. II. In vitro and in vivo evaluation in the rat [J]. J Control Release, 2000, 63: 129-134.
11. Sihna VR, Kumria R. Microbial triggered drug delivery to colon [J]. Eur J Pharm Sci, 2003, 18: 3-18.
12. Choursia MK, Jain SK. Potential of guar gum microspheres for target specific drug release to colon [J]. J Drug Target, 2004, 12: 435-442.