Radiation-Related Heart Disease: Current Knowledge and Future Prospects

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 3, 2010, Pages 656-665

  Darby, Sarah C ^a   Cutter, David J ^a   Boerma, Marjan ^b   Constine, Louis S ^c   Fajardo, Luis F ^d   Kodama, Kazunori ^e   Mabuchi, Kiyohiko ^f   Marks, Lawrence B ^g   Mettler, Fred A ^h   Pierce, Lori J ⁱ   Trott, Klaus R ^j   Yeh, Edward T H ^k   Shore, Roy E ^e  

^a CLINICAL TRIAL SERVICE UNIT   (United Kingdom)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^f NATIONAL CANCER INSTITUTE   (United States)

^g UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^h NEW MEXICO VA HEALTH CARE SYSTEM   (United States)

ⁱ UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^j UNIVERSITY COLLEGE LONDON   (United Kingdom)

^k UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMIFOSTINE; ANTHRACYCLINE; CAPTOPRIL; IBUPROFEN; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOXIFYLLINE; TAXANE DERIVATIVE; TRASTUZUMAB;

ATHEROSCLEROTIC PLAQUE; BREAST CANCER; CANCER RADIOTHERAPY; CARDIOMYOPATHY; CARDIOTOXICITY; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; HEART DISEASE; HEART INFARCTION; HEART MUSCLE FIBROSIS; HODGKIN DISEASE; HUMAN; NONHUMAN; PATHOGENESIS; PATIENT MONITORING; PERICARDIAL EFFUSION; PERICARDIECTOMY; PERICARDIOCENTESIS; PERICARDITIS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; RADIATION RELATED HEART DISEASE; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TESTIS CANCER; VALVULAR HEART DISEASE; X IRRADIATION;

ANIMALS; BREAST NEOPLASMS; CORONARY ARTERY DISEASE; FEMALE; FIBROSIS; FORECASTING; HEART; HODGKIN DISEASE; HUMANS; MALE; MODELS, ANIMAL; MYOCARDIUM; OCCUPATIONAL EXPOSURE; PERICARDITIS; RADIATION INJURIES; RADIOACTIVE FALLOUT; RADIOTHERAPY DOSAGE;

EID: 76049097881     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.09.064     Document Type: Review

References (56)

1. Fajardo L.F., Berthrong M., and Anderson R.E. Radiation pathology (2001), Oxford University Press, New York
2. Schultz-Hector S., and Trott K.R. Radiation-induced cardiovascular diseases: Is the epidemiologic evidence compatible with the radiobiologic data?. Int J Radiat Oncol Biol Phys 67 (2007) 10-18
3. Fajardo L.F., and Stewart J.R. Pathogenesis of radiation-induced myocardial fibrosis. Lab Invest 29 (1973) 244-257
4. Fajardo L.F. The pathology of ionizing radiation as defined by morphologic patterns. Keynote lecture, 5th Nordic Conference on Radiation Oncology, Bergen, Norway. Acta Oncologica 44 (2005) 13-22
5. Veinot J.P., and Edward W.D. Pathology of radiation-induced heart disease: A surgical and autopsy study of 27 cases. Hum Pathol 8 (1996) 766-773
6. Lauk S. Strain differences in the radiation response of the rat heart. Radiother Oncol 5 (1986) 333-335
7. McChesney S.L., Gillette E.L., and Powers B.E. Radiation-induced cardiomyopathy in the dog. Radiat Res 113 (1988) 120-132
8. Lauk S., Kiszel Z., Buschmann J., et al. Radiation-induced heart disease in rats. Int J Radiat Oncol Biol Phys 11 (1985) 801-808
9. Schultz-Hector S., Sund M., and Thames H.D. Fractionation sensitivity and repair kinetics of radiation-induced heart failure in rats. Radiother Oncol 23 (1992) 33-40
10. Schulz-Hector S., and Balz K. Radiation-induced loss of endothelial alkaline phosphatase activity and development of myocardial degeneration. An ultrastructural study. Lab Invest 71 (1994) 252-260
11. -/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. Am J Pathol 168 (2006) 649-658
12. Reeves W.C., Cunningham D., Schwiter E.J., et al. Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease. Circulation 65 (1982) 924-927
13. Yarom R., Harper I.S., Wynchank S., et al. Effect of captopril on changes in rats' hearts induced by long-term irradiation. Radiat Res 133 (1993) 187-197
14. Kruse J.J., Strootman E.G., and Wondergem J. Effects of amifostine on radiation-induced cardiac damage. Acta Oncol 42 (2003) 4-9
15. Boerma M., Roberto K.A., and Hauer-Jensen M. Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol. Int J Radiat Oncol Biol Phys 72 (2008) 170-177
16. Carmel R.J., and Kaplan H.S. Mantle irradiation in Hodgkin's disease. An analysis of technique, tumor eradication, and complications. Cancer 37 (1976) 2813-2825
17. Clare G.C., and Troughton R.W. Management of constrictive pericarditis in the 21st century. Curr Treat Options Cardiovasc Med 9 (2007) 436-442
18. Heidenreich P.A., Hancock S.L., Lee B.K., et al. Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol 42 (2003) 743-749
19. Glanzmann C., Kaufman P., Jenni R., et al. Cardiac risk after mediastinal irradiation for Hodgkin's disease. Radiother Oncol 46 (1998) 51-62
20. Hull M.C., Morris C.G., Pepine C.J., et al. Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of Hodgkin lymphoma treated with radiation therapy. JAMA 290 (2003) 2831-2837
21. Carlson R.G., Mayfield W.R., Normann S., et al. Radiation-associated valvular disease. Chest 99 (1991) 538-545
22. Mertens A.C., Liu Q., Neglia J.P., et al. Cause-specific late mortality among 5-year survivors of childhood cancer: The Childhood Cancer Survivor Study. J Natl Cancer Inst 100 (2008) 1368-1379
23. Hancock S.L., Donaldson S.S., and Hoppe R.T. Cardiac disease following treatment of Hodgkin's disease in children and adolescents. J Clin Oncol 7 (1993) 1208-1215
24. Lipshultz S.E., and Sallan S.E. Cardiovascular abnormalities in long-term survivors of childhood malignancy. J Clin Oncol 11 (1993) 1199-1203
25. Adams M.J., Lipsitz S.R., Colan S.D., et al. Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapy. J Clin Oncol 22 (2004) 3139-3148
26. Hancock S.L., Tucker M.A., and Hoppe R.T. Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. JAMA 270 (1993) 1949-1955
27. Brown M.L., Schaff H.V., and Sundt T.M. Conduit choice for coronary artery bypass grafting after mediastinal radiation. J Thorac Cardiovasc Surg 136 (2008) 1167-1171
28. Fosså S.D., Gilbert E., Dores G.M., et al. Noncancer causes of death in survivors of testicular cancer. J Natl Cancer Inst 99 (2007) 533-544
29. Carr Z.A., Land C.E., Kleinerman R.A., et al. Coronary heart disease after radiotherapy for peptic ulcer disease. Int J Radiat Oncol Biol Phys 61 (2005) 842-850
30. Aleman B.M., van den Belt-Dusebout A.W., De Bruin M.L., et al. Late cardiotoxicity after treatment for Hodgkin's lymphoma. Blood 109 (2007) 1878-1886
31. Swerdlow A.J., Higgins C.D., Smith P., et al. Myocardial infarction mortality risk after treatment for Hodgkin disease: A collaborative British cohort study. J Natl Cancer Inst 99 (2007) 206-214
32. Henry-Amar M., Hayat M., Meerwaldt J.H., et al., EORTC Lymphoma Cooperative Group. Causes of death after therapy for early stage Hodgkin's disease entered on EORTC protocols. Int J Radiat Oncol Biol Phys 19 (1990) 1155-1157
33. Myrehaug S., Pintilie M., Tsang R., et al. Cardiac morbidity following modern treatment for Hodgkin lymphoma: Supra-additive cardiotoxicity of doxorubicin and radiation therapy. Leuk Lymphoma 49 (2008) 1486-1493
34. Cuzick J., Stewart H., Peto R., et al. Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. Cancer Treat Rep 71 (1987) 15-29
35. Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 366 (2005) 2087-2106
36. Taylor C.W., Nisbet A., McGale P., et al. Cardiac exposures in breast cancer radiotherapy: 1950's-1990's. Int J Radiat Oncol Biol Phys 69 (2007) 1484-1495
37. Early Breast Cancer Trialists' Collaborative Group. Long term toxicity of radiation therapy. In: 2006 Update of the Early Breast Cancer Trialists' Collaborative group overview of radiation therapy for early breast cancer. 2007 American Society of Clinical Oncology Annual Meeting, June 1-5 2007, Chicago.
38. McGale P., and Darby S.C. Commentary: A dose-response relationship for radiation-induced heart disease--C-urrent issues and future prospects. Int J Epidemiol 37 (2008) 518-523
39. Darby S.C., McGale P., Taylor C.W., et al. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: Prospective study of about 300,000 women in US SEER cancer registries. Lancet Oncol 6 (2005) 557-565
40. Correa C.R., Litt H.I., Hwang W.T., et al. Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer. J Clin Oncol 25 (2007) 3031-3037
41. Goethals I., Dierckx R., De Meerler G., et al. The role of nuclear medicine in the prediction and detection of radiation-associated normal pulmonary and cardiac damage. J Nucl Med 44 (2003) 1531-1539
42. Marks L.B., Xiaoli Y., Prosnitz R.G., et al. The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 63 (2005) 214-223
43. Prosnitz R.G., Hubbs J.L., Evans E.S., et al. Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: Analysis of data 3 to 6 years after treatment. Cancer 110 (2007) 1840-1850
44. Preston D.L., Shimizu Y., Pierce D.A., et al. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 160 (2003) 381-407
45. Yamada M., Wong F.L., Fujiwara S., et al. Noncancer disease incidence in atomic bomb survivors, 1958-1998. Radiat Res 161 (2004) 622-632
46. Hakoda M., Kasagi F., Kusunoki Y., et al. Levels of antibodies to microorganisms implicated in atherosclerosis and of C-reactive protein among atomic bomb survivors. Radiat Res 166 (2006) 360-366
47. Wong F.L., Yamada M., Sasaki H., et al. Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors. Radiat Res 151 (1999) 736-746
48. Matanoski G.M., Sartwell P.E., Elliott E.A., et al. Cancer risks in radiologists and radiation workers. In: Boice J.D., and Fraumeni J.F. (Eds). Radiation carcinogenesis: Epidemiology and biological significance (1984), Raven Press, New York
49. Berrington A., Darby S.C., Weiss H.A., et al. 100 years of observation on British radiologists: Mortality from cancer and other causes 1897-1997. Br J Radiol 74 (2001) 507-519
50. Hauptmann M., Mohan A.K., Doody M.M., et al. Mortality from diseases of the circulatory system in radiologic technologists in the United States. Am J Epidemiol 157 (2003) 239-248
51. CARDIORISK--The mechanism of cardiovascular risks after low radiation doses. http://www.cardiorisk.eu/.
52. Collaborative Group on Observational Studies of Breast Cancer Survivors (COBS). http://www.ctsu.ox.ac.uk/projects/cobs/.
53. RACE---Radiation associated cardiac events. http://www.race.ki.se/.
54. Taylor C.W., Povall J.M., McGale P., et al. Cardiac dose from tangential breast cancer radiotherapy in the year 2006. Int J Radiat Oncol Biol Phys 72 (2008) 501-507
55. Pierce L.J., Butler J.B., Martel M.K., et al. Post-mastectomy radiotherapy of the chest wall: dosimetric comparison of common techniques. Int J Radiat Oncol Biol Phys 52 (2002) 1220-1230
56. Carver J.R., Shapiro C.L., Ng A., et al. American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: Cardiac and pulmonary late effects. J Clin Oncol 25 (2007) 3991-4008