Effect of gamma irradiation sterilization on drug release from in situ forming injectable implant systems

Ankara Universitesi Eczacilik Fakultesi Dergisi

Volumn 37, Issue 1, 2008, Pages 1-10

  Alǧin Yapar, Evren ^a   Baykara, Tamer ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Gamma irradiation sterilization; Granisetron HCl; In situ implant; Injectable; Poly(DL lactide co glycolide)

Indexed keywords

BENZYL BENZOATE; GRANISETRON; PHOSPHATE BUFFERED SALINE; POLYGLACTIN; POLYMER;

ARTICLE; CONTROLLED STUDY; DISSOLUTION; DRUG RELEASE; DRUG SOLUBILITY; GAMMA IRRADIATION; HARDNESS; IMPLANTABLE PORT SYSTEM; IN VITRO STUDY; INSTRUMENT STERILIZATION; MOLECULAR WEIGHT; PH; RADIOSENSITIVITY; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 76049092497     PISSN: 10153918     EISSN: 25646524     Source Type: Journal    
DOI: 10.1501/eczfak_0000000487     Document Type: Article

References (17)

1. Wright, J.C., Leonard, S.T., Stevenson, C.L., Beck, J.C., Chen, G., Jao R.M. et al. "An in vivo/ in vitro comparison with a leuprolide osmotic implant for the treatment of prostate cancer" J. Control. Release, 75, 1-10, (2001).
2. Dunn, R.L., English, J.P., Cowsar, D.R., Vanderbilt, D.P. "Biodegradable in-situ forming implants and methods of producing" US Patent, 5990194, (1999).
3. Hatefi A., Amsden B. "Biodegradable injectable in-situ forming drug delivery systems" J. Control. Release, 80, 9-28, (2002).
4. Packhaueser, C.B., Schneiders, J., Oster, C.G., Kissel, T. "In situ forming parenteral drug delivery systems" Eur. J. Pharm Biopharm., 58, 445-455, (2004).
5. Astaneh, R., Moghimi, H.R., Erfan, M., Mobedi, H. "Formulation of an injectable implant for peptide delivery and mechanistic study of the effect of polymer molecular weight on its release behaviour" Daru, 14(2), 65-70, (2006).
6. Algin Yapar, E., Baykara, T. "Effects of solvent combinations on drug release from injectable phase sensitive liquid implants" Turkish J. Pharmaceutical Sciences, 7(1), xx, (2010), (in press).
7. Bernkopf, M. "Sterilisation of bioresorbable polymer implants" Medical Device Technology, 4, 26-29, (2007).
8. Hausberger, A.G., Kenley, R.A., Deluca, P.P. "Gamma- irradiation effects on molecular weight and in vitro degradation of poly(DL-lactide-co-glycolide) microparticles" Pharm. Res., 12(6), 851-856, (1995).
9. Igartua, M., Hernández, R.M., Rosas, J.E., Patarroyo, M.E., Pedraz. J.L. "γ-Irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine" Eur. J. Pharm. Biopharm, 65(1), 91-102, (2008).
10. Friess, W., Schlapp, M. "Sterilization of gentamicin containing collagen/PLGA microparticle composites" Eur. J. Pharm. Biopharm., 63(2), 176-187, (2006).
11. Aapro, M. "Granisetron: an update on its clinical use in the management of nausea and vomiting" The Oncologist, 9, 673, (2004).
12. European Pharmacopoeia, 6th, Council of Europe, Strasbourg Cedex, France, (2007).
13. Moore, J.W., Flanner, H.H. "Mathematical Comparison of curves with an emphasis on in vitro dissolution profiles" Pharm. Tech., 20(6), 64-74, (1996).
14. Luan, X., Bodmeier, R. "In situ forming microparticle system for controlled delivery of leuprolide acetate: influence of the formulation and processing parameters" Eur. J. of Pharm. Sci., 27, 143-149, (2006).
15. Astaneh, R., Erfan, M., Moghimi, H.R., Mobedi, H. "Changes in morphology of in situ forming plga implant prepared by different polymer molecular weight and its effect on release behavior" J. of Pharm. Sci., DOI 10.1002/jps.21415, (2008).
16. Ravivarapu, H.B., Moyer, K.L., Dunn, R.L. "Sustained activity and release of leuprolide acetate from an in situ forming polymeric implant" AAPS Pharm. Sci.Tech., 1(1), 1-8, (2000).
17. Bushell, J. A., Claybourn, M., Williams, H.E., Murphy, D.M. "An EPR and ENDOR study of g- and h-radiation sterilization in poly (lactide-co-glycolide) polymers and microspheres" J. Control. Release, 110, 49-57, (2005).