Risk of serious bacterial infection in isolated and unsuspected neutropenia

Academic Emergency Medicine

Volumn 17, Issue 2, 2010, Pages 163-167

  Melendez, Elliot ^a   Harper, Marvin B ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Absolute neutrophil count; Bacteremia; Neutropenia; Sepsis; Serious bacterial infection

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BACTEREMIA; BACTERIAL INFECTION; BACTERIUM CULTURE; BLOOD CELL COUNT; BLOOD CULTURE; CEREBROSPINAL FLUID CULTURE; CHILD; CLINICAL EVALUATION; EMERGENCY CARE; EMERGENCY WARD; FEMALE; HUMAN; INFANT; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MENINGITIS; NEUTROPENIA; NEUTROPHIL COUNT; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SCHOOL CHILD; URINARY TRACT INFECTION; URINE CULTURE;

ADOLESCENT; BACTEREMIA; BACTERIAL INFECTIONS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; MENINGITIS, BACTERIAL; NEUTROPENIA; PREVALENCE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; YOUNG ADULT;

EID: 76049085273     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/j.1553-2712.2009.00649.x     Document Type: Article

References (14)

1. Pincus SH, Boxer LA, Stossel TP. Chronic neutropenia in childhood. Analysis of 16 cases and a review of the literature. Am J Med. 1976; 61:849-61.
2. Howard MW, Strauss RG, Johnston RB Jr. Infections in patients with neutropenia. Am J Dis Child. 1977; 131:788-90.
3. Conway LT, Clay ME, Kline WE, Ramsay NK, Krivit W, McCullough J. Natural history of primary autoimmune neutropenia in infancy. Pediatrics. 1987; 79:728-33.
4. Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med. 1966; 64:328-40.
5. Lucas KG, Brown AE, Armstrong D, Chapman D, Heller G. The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis. Cancer. 1996; 77:791-8.
6. Dale DC, Guerry D 4th, Wewerka JR, Bull JM, Chusid MJ. Chronic neutropenia. Medicine (Baltimore). 1979; 58:128-44.
7. Serwint JR, Dias MM, Chang H, Sharkey M, Walker AR. Outcomes of febrile children presumed to be immunocompetent who present with leukopenia or neutropenia to an ambulatory setting. Clin Pediatr (Phila). 2005; 44:593-600.
8. Vlacha V, Feketea G. The clinical significance of non-malignant neutropenia in hospitalized children. Ann Hematol. 2007; 86:865-70.
9. Bonadio WA, Stremski E, Shallow K. Clinical characteristics of children with fever and transient neutropenia who experience serious bacterial infections. Pediatr Emerg Care. 1989; 5:163-5.
10. Leibovici L, Drucker M, Samra Z, Konisberger H, Pitlik SD. Prognostic significance of the neutrophil count in immunocompetent patients with bacteraemia. QJM. 1995; 88:181-9.
11. Bonadio WA, Smith DS, Mathews S, Rock A. Clinical significance of newly documented neutropenia in febrile young infants evaluated for sepsis. Pediatr Infect Dis J. 1991; 10:407-8.
12. Alario AJ, O'Shea JS. Risk of infectious complications in well-appearing children with transient neutropenia. Am J Dis Child. 1989; 143:973-6.
13. Hughes WT, Armstrong D, Bodey GP, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002; 34:730-51.
14. Bachur RG, Harper MB. Predictive model for serious bacterial infections among infants younger than 3 months of age. Pediatrics. 2001; 108:311-6.