Levetiracetam as add-on therapy in different subgroups of "benign" idiopathic focal epilepsies in childhood

Epilepsy and Behavior

Volumn 17, Issue 2, 2010, Pages 193-198

  von Stulpnagel C ^a   Kluger, G ^a   Leiz, S ^b   Holthausen, H ^a  

^a Clinic for Neuropediatrics and Neurologic Rehabilitation   (Germany)

^b Klinikum Dritter Orden   (Germany)

Author keywords

Benign idiopathic focal epilepsies of childhood; Electrical status epilepticus during sleep; Landau Kleffner syndrome; Levetiracetam; Rolandic epilepsy

Indexed keywords

CLOBAZAM; CLONAZEPAM; ETHOSUXIMIDE; ETIRACETAM; LAMOTRIGINE; LORAZEPAM; OXCARBAZEPINE; STIRIPENTOL; SULTIAME; TETRACOSACTIDE; VALPROIC ACID;

ADD ON THERAPY; ADOLESCENT; ARTICLE; BEHAVIOR DISORDER; BENIGN CHILDHOOD EPILEPSY; CHILD; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DECREASED APPETITE; DISEASE CLASSIFICATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; EPILEPTIC DISCHARGE; FATIGUE; FECES INCONTINENCE; FEMALE; FOCAL EPILEPSY; GAIT DISORDER; HALITOSIS; HUMAN; HYPERSALIVATION; IDIOPATHIC DISEASE; INCONTINENCE; IRRITABILITY; LANDAU KLEFFNER SYNDROME; LANGUAGE; MALE; MONOTHERAPY; OUTCOME ASSESSMENT; PRESCHOOL CHILD; ROLANDIC EPILEPSY; SCHOOL CHILD; SEIZURE; SIDE EFFECT; SLEEP DISORDER; SPEECH DISORDER; SPIKE WAVE; TREATMENT DURATION; TREATMENT RESPONSE; URINE INCONTINENCE;

ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; COGNITION DISORDERS; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; FEMALE; HUMANS; LANDAU-KLEFFNER SYNDROME; LANGUAGE DISORDERS; LANGUAGE TESTS; MALE; NEUROPSYCHOLOGICAL TESTS; PIRACETAM; SEVERITY OF ILLNESS INDEX;

EID: 75949117145     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.10.024     Document Type: Article

References (63)

1. Klitgaard H., Matagne A., Gobert J., and Wülfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur J Pharmacol 24 353 (1998) 191-206
2. Klitgaard H. Levetiracetam: the preclinical profile of a new class of antiepileptic drugs?. Epilepsia 42 Suppl. 4 (2001) 13-18
3. Aksu F. Levetriracetam bei Kindern-neue Ergebnisse und erste Langzeiterfahrungen: eine Literaturübersicht. Neuropaediatrie 4 (2004) 126-130
4. Vigevano F. Levetiracetam in pediatrics: topical review. J Child Neurol 20 (2005) 87-93
5. Aeby A., Poznanski N., Verheulpen D., Wetzburger C., and Van Bogaert P. Levetiracetam efficacy in epileptic syndromes with continuous spikes and waves during slow sleep: experience in 12 cases. Epilepsia 46 (2005) 1937-1942
6. Bello-Espinosa L.E., and Roberts S.L. Levetiracetam for benign epilepsy of childhood with centrotemporal spikes: three cases. Seizure 12 (2003) 157-159
7. Gustafson M.C., Ritter F.J., Frost M.D., Karney V.L., and Hoskin C. Clinical experience with levetiracetam treating refractory, symptomatic seizures in children. Epilepsia 42 Suppl. 7 (2001) 55 [abstract 1.171]
8. Hoppen T., Sandrieser T., and Rister M. Successful treatment of pharmacoresistent continuous spike wave activity during slow sleep with levetiracetam. Eur J Pediatr 162 (2003) 59-61
9. Martland T., Osman A., and Huyton M. The effectiveness of levetiracetam in children with complex epilepsy. Epilepsia 43 Suppl. 8 (2002) 36
10. Nieto Barrera M., Martinez Anton J., Candau R., et al. Efficacy of levetiracetam in children with partial seizures. Epilepsia 45 Suppl. 3 (2004) 143
11. Opp J., Tuxhorn I., May Th., et al. Levetiracetam in children with refractory epilepsy: a multicenter open label study in Germany. Seizure 14 (2005) 476-484
12. Rasmini P., et al. Levetiracetam (LEV) as add-on therapy in childhood drug resistant epilepsy. Epilepsia 45 Suppl. 3 (2004) 143
13. Coppola G. Treatment of partial seizures in childhood: an overview. CNS Drugs 18 (2004) 133-156
14. Glauser T.A., Ayala R., Elterman R.D., et al. Double-blind placebo-controlled trial of adjunctive levetiracetam in paediatric partial seizures. Neurology 66 (2006) 1654-1666
15. Mikati M.A., and Shamseddine A.N. Management of Landau-Kleffner syndrome. Paediatr Drugs 7 (2005) 377-389
16. Khurana D.S., Kothare S.V., Valencia I., Melvin J.J., and Legido A. Levetiracetam monotherapy in children with epilepsy. Pediatr Neurol 36 (2007) 227-230
17. Lagae L., Buyse G., and Ceulemans B. Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial. Seizure 14 (2005) 66-71
18. Grosso S., Franzoni E., Coppola G., et al. Efficacy and safety of levetiracetam: an add-on trial in children with refractory epilepsy. Seizure 14 (2005) 248-253
19. Deonna T. Rolandic epilepsy: neuropsychology of the active epilepsy phase. Epileptic Disord 2 Suppl. 1 (2000) S59-S61
20. Nicolai J., Aldenkamp A.P., Arends J., Weber J.W., and Vles J.S. Cognitive and behavioral effects of nocturnal epileptiform discharges in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav 8 (2006) 56-70
21. Yung A.W., Park Y.D., Cohen M.J., and Garrison T.N. Cognitive and behavioural problems in children with centrotemporal spikes. Pediatr Neurol 23 (2000) 391-395
22. De Tiège X., Goldman S., Verheulpen D., Aeby A., Poznanski N., and Van Bogaert P. Coexistence of idiopathic rolandic epilepsy and CSWS in two families. Epilepsia 47 (2006) 1723-1727
23. Tassinari C.A., Rubboli G., Volpi L., Billard C., and Bureau M. Electrical status epilepticus during slow sleep (ESES or CSWS) including acquired epileptic aphasia (Landau-Kleffner syndrome). In: Roger J., Dravet Ch., Bureau M., Genton P., Tassinari C.A., and Wolf P. (Eds). Epileptic syndromes in infancy, childhood and adolescence. 4th ed. (2005), John Libbey Eurotext, London p. 305
24. Pinton F., Ducot B., Motte J., et al. Cognitive functions in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Epileptic Disord 8 (2006) 11-23
25. Aicardi J., and Chevrie J.J. Atypical benign partial epilepsy of childhood. Dev Med Child Neurol 24 (1982) 281-292
26. Panayiotopoulos C.P., Michael M., Sanders S., Valeta T., and Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 131 Pt. 9 (2008) 2264-2286
27. Wheless J.W., Clarke D.F., Arzimanoglou A., and Carpenter D. Treatment of paediatric epilepsy: European expert opinion 2007. Epileptic Disord 9 (2007) 353-412
28. Wheless J.W., Clarke D.F., and Carpenter D. Treatment of paediatric epilepsy: expert opinion. J Child Neurol Suppl. 1 (2005) S1-56
29. Rating D., Wolf C., and Bast T. For the Sulthiame Study Group. Sulthiame as monotherapy in children with benign childhood epilepsy with centrotemporal spikes: a 6-month randomized, double-blind, placebo-controlled study. Epilepsia 41 (2000) 1284-1288
30. Bast T., Volp A., Wolf C., and Rating D. For the Sulthiame Group. The influence of sulthiame on EEG in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Epilepsia 44 (2003) 215-220
31. Engler F., Maeder-ingvar M., Roulet E., and Deonna T. Treatment with sulthiame (Ospolot) in benign partial epilepsy of childhood and related syndromes: an open clinical and EEG study. Neuropediatrics 34 (2003) 105-109
32. Dalla B.B., Sgrò V., and Fejerman N. Epilepsy with centro-temporal spikes and related syndromes. In: Roger J., Dravet Ch., Bureau M., Genton P., Tassinari C.A., and Wolf P. (Eds). Epileptic syndromes in infancy, childhood and adolescence. 4th ed (2005), John Libbey Eurotext, London 213
33. Kochen S., Giagante B., and Oddo S. Spike-and-wave complex and seizure exacerbation caused by carbamazepine. Eur J Neurol 9 (2002) 41-47
34. Nanba Y., and Maegaki Y. Epileptic negative myoclonus induced by carbamazepine in a child with BECTS: benign childhood epilepsy with centrotemporal spikes. Pediatr Neurol 21 (1999) 664-667
35. Kikumoto K., Yoshinaga H., Oka M., et al. EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. Epileptic Disord 8 (2006) 53-56
36. Grosso S., Balestri M., Di Bartolo R.M., et al. Oxcarbazepine and atypical evolution of benign idiopathic focal epilepsy of childhood. Eur J Neurol 13 (2006) 1142-1145
37. Dalla B.B., Sgrò V., and Fejerman N. Epilepsy with centro-temporal spikes and related syndromes. In: Roger J., Dravet Ch., Bureau M., Genton P., Tassinari C.A., and Wolf P. (Eds). Epileptic syndromes in infancy, childhood and adolescence. 4th ed (2005), John Libbey Eurotext, London 204-207
38. Perucca E. The management of refractory idiopathic epilepsies. Epilepsia 42 Suppl. 3 (2001) 31-35
39. Ambrosetto G., and Tassinari C.A. Antiepileptic drug treatment of benign childhood epilepsy with rolandic spikes: is it necessary?. Epilepsia 31 (1990) 802-805
40. Ambrosetto G., Giovanardi Rossi P., and Tassinari C.A. Predictive factors of seizure frequency and duration of antiepileptic treatment in rolandic epilepsy: a retrospective study. Brain Dev 9 (1987) 300-304
41. Hamada Y., Okuno T., Hattori H., and Mikawa H. Indication for anti-epileptic treatment of benign childhood epilepsy with centro-temporal spikes. Brain Dev 16 (1994) 159-161
42. Arts W.F., and Geerts A.T. When to start drug treatment for childhood epilepsy: the clinical-epidemiological evidence. Eur J Paediatr Neurol 13 (2009) 93-101
43. Staden U., Isaacs E., Boyd S.G., Brandl U., and Neville B.G. Language dysfunction in children with rolandic epilepsy. Neuropediatrics 29 (1998) 242-248
44. Papavasiliou A., Mattheou D., Bazigou H., Kotsalis C., and Paraskevoulakos E. Written language skills in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav 6 (2005) 50-58
45. Northcott E., Connolly A.M., Berroya A., et al. The neuropsychological and language profile of children with benign rolandic epilepsy. Epilepsia 46 (2005) 924-930
46. Liasis A., Bamiou D.E., Boyd S., and Towell A. Evidence for a neurophysiologic auditory deficit in children with benign epilepsy with centro-temporal spikes. J Neural Transm 113 (2006) 939-949
47. Giordani B., Caveney A.F., Laughrin D., et al. Cognition and behaviour in children with benign epilepsy with centrotemporal spikes (BECTS). Epilepsy Res 70 (2006) 89-94
48. Piccinelli P., Borgatti R., Aldini A., et al. Academic performance in children with rolandic epilepsy. Dev Med Child Neurol 50 (2008) 353-356
49. Boatman D.F., Trescher W.H., Smith C., et al. Cortical auditory dysfunction in benign rolandic epilepsy. Epilepsia 49 (2008) 1018-1026
50. Duman O., Kizilay F., Fettahoglu C., Ozkaynak S., and Haspolat S. Electrophysiologic and neuropsychologic evaluation of patients with centrotemporal spikes. Int J Neurosci 118 (2008) 995-1008
51. Kavros P.M., Clarke T., Strug L.J., Halperin J.M., Dorta N.J., and Pal D.K. Attention impairment in rolandic epilepsy: systematic review. Epilepsia 49 (2008) 1570-1580
52. Marescaux C., Hirsh E., Finck S., et al. Landau-Kleffner syndrome. A pharmacologic study of five cases. Epilepsia 31 (1990) 768-777
53. Ravnik I. A case of Landau-KLeffner syndrome: effect of intravenous diazepam. In: Roger J., Dravet Ch., Bureau M., Genton P., Tassinari C.A., and Wolf P. (Eds). Epileptic syndromes in infancy, childhood and adolescence. 4th ed. (2005), John Libbey Eurotext, London 192-193
54. Inutsuka M., Kobayashi K., Oka M., Hattori J., and Ohtsuka Y. Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. Brain Dev 28 (2006) 281-286
55. Yasuhara A., Yoshida H., Hatanaka T., Sugimoto T., Kobayashi Y., and Dyken E. Epilepsy with continuous spike-waves during slow sleep and its treatment. Epilepsia 32 (1991) 59-62
56. Gross-Selbeck G. Treatment of "benign" partial epilepsies of childhood, including atypical forms. Neuropediatrics 26 (1995) 45-50
57. Rating D. Treatment in typical and atypical rolandic epilepsy. Epileptic Disord 2 Suppl. 1 (2000) S69-S72
58. Kossoff E.H., Los J.G., and Boatman D.E. A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy. Epilepsy Behav 11 (2007) 514-517
59. Verrotti A., Coppola G., Manco R., et al. Levetiracetam monotherapy for children and adolescents with benign rolandic seizures. Seizure 16 (2007) 271-275
60. Doose H. Symptomatology in children with focal sharp waves of genetic origin. Eur J Pediatr 149 (1989) 210-215
61. Aicardi J. Atypical semiology of rolandic epilepsy in some related syndromes. Epileptic Disord 2 (2000) S5-S9
62. Berkovic S.F., Knowlton R.C., Leroy R.F., Schiemann J., and Falter U. For the Levetiracetam NO1057 Study Group. Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology 69 (2007) 1751-1760
63. Noachtar S., Andermann E., Meyvisch P., Andermann F., Gough W.B., and Schiemann-Delgado J. For the N166 Levetiracetam Study Group. Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology 70 (2008) 607-616