The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-α and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner

Immunology

Volumn 129, Issue 3, 2010, Pages 375-385

  Avni, Dorit ^a   Philosoph, Amir ^a   Meijler, Michael M ^b   Zor, Tsaffrir ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Cyclic adenosine monophosphate response element binding protein; Inflammation; Interleukin 10; Lipopolysaccharide; Macrophages; Tumour necrosis factor

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CELL ENZYME; CERAMIDE 1 PHOSPHATE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; INTERLEUKIN 10; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; SERINE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; MACROPHAGE; MODULATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ADENYLATE CYCLASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUCLADESINE; CALCIUM SIGNALING; CELL LINE; CELL MEMBRANE; CERAMIDES; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; ENZYME INHIBITORS; GENES, REPORTER; GUANOSINE TRIPHOSPHATE; IMIDAZOLES; INDOLES; INTERLEUKIN-10; ISOQUINOLINES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; RESPONSE ELEMENTS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; ROLIPRAM; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 75949093797     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03188.x     Document Type: Article

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