Expression of PROX1 is a common feature of high-grade malignant astrocytic gliomas

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 2, 2010, Pages 129-138

  Elsir, Tamador ^a   Eriksson, Anna ^a   Orrego, Abiel ^a   Lindström, Mikael S ^a   Nistér, Monica ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

AIII tubulin; Astrocytoma; Diagnostic marker; Glioblastoma; Immunohistochemistry; Neuronal marker; PROX1

Indexed keywords

BETA TUBULIN; MICROTUBULE ASSOCIATED PROTEIN 2; PROTEIN; PROTEIN PROX1; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTIBODY LABELING; ARTICLE; ASTROCYTOMA; CANCER GRADING; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, NUCLEAR; ASTROCYTOMA; BIOLOGICAL MARKERS; BRAIN DISEASES; BRAIN NEOPLASMS; CELL PROLIFERATION; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROTUBULE-ASSOCIATED PROTEINS; MICROVESSELS; MITOSIS; NERVE TISSUE PROTEINS; TUBULIN; TUMOR SUPPRESSOR PROTEINS;

EID: 75949088814     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181ca4767     Document Type: Article

References (47)

1. Kapoor GS, O'Rourke DM. Mitogenic signaling cascades in glial tumors. Neurosurgery 2003;52:1425-34
2. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radio-resistance by preferential activation of the DNA damage response. Nature 2006;444:756-60
3. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-28
4. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004;432:396-401
5. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114: 97-109
6. Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev 2007;21:2683-710
7. Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008; 359:492-507
8. Tomarev SI, Zinovieva RD, Chang B, et al. Characterization of the mouse Prox1 gene. Biochem Biophys Res Commun 1998;248:684-89
9. Zinovieva RD, Duncan MK, Johnson TR, et al. Structure and chromosomal localization of the human homeobox gene Prox 1. Genomics 1996;35:517-22
10. Kamiya A, Kakinuma S, Onodera M, et al. Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts. Hepatology 2008;48:252-64
11. Sosa-Pineda B, Wigle JT, Oliver G. Hepatocyte migration during liver development requires Prox1. Nat Genet 2000;25:254-55
12. Tammela T, Petrova TV, Alitalo K. Molecular lymphangiogenesis: New players. Trends Cell Biol 2005;15:434-41
13. Petrova TV, Makinen T, Makela TP, et al. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J 2002;21:4593-99
14. Wigle JT, Chowdhury K, Gruss P, et al. Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 1999;21:318-22
15. Nagai H, Li Y, Hatano S, et al. Mutations and aberrant DNA methyl-ation of the PROX1 gene in hematologic malignancies. Genes Chromosomes Cancer 2003;38:13-21
16. Versmold B, Felsberg J, Mikeska T, et al. Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. Int J Cancer 2007;121:547-54
17. Laerm A, Helmbold P, Goldberg M, et al. Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epige-netic silencing in carcinomas of the biliary system. J Hepatol 2007;46: 89-97
18. Petrova TV, Nykanen A, Norrmen C, et al. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell 2008;13:407-19
19. Misra K, Gui H, Matise MP. Prox1 regulates a transitory state for inter-neuron neurogenesis in the spinal cord. Dev Dyn 2008;237:393-402
20. Torii M, Matsuzaki F, Osumi N, et al. Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development 1999;126:443-56
21. Galeeva A, Treuter E, Tomarev S, et al. A prospero-related homeobox gene Prox-1 is expressed during postnatal brain development as well as in the adult rodent brain. Neuroscience 2007;146:604-16
22. Lavado A, Oliver G. Prox1 expression patterns in the developing and adult murine brain. Dev Dyn 2007;236:518-24
23. Lindgren RM, Zhao J, Heller S, et al. Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain. Gene 2005;348:143-55
24. Phi JH, Park SH, Kim SK, et al. Sox2 expression in brain tumors: A reflection of the neuroglial differentiation pathway. Am J Surg Pathol 2008;32:103-12
25. Jones DT, Ichimura K, Liu L, et al. Genomic analysis of pilocytic astro-cytomas at 0.97 Mb resolution shows an increasing tendency toward chromosomal copy number change with age. J Neuropathol Exp Neurol 2006;65:1049-58
26. Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 2008;68:8673-77
27. Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008;321:1807-12
28. Anderson JC, McFarland BC, Gladson CL. New molecular targets in an-giogenic vessels of glioblastoma tumours. Expert Rev Mol Med 2008; 10:e23
29. Quinones-Hinojosa A, Sanai N, Smith JS, et al. Techniques to assess the proliferative potential of brain tumors. J Neurooncol 2005;74:19-30
30. Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): A dancer with many partners. J Cell Sci 2003;116:3051-60
31. Chen X, Patel TP, Simirskii VI, et al. PCNA interacts with Prox1 and represses its transcriptional activity. Mol Vis 2008;14:2076-86
32. Katsetos CD, Del Valle L, Geddes JF, et al. Aberrant localization of the neuronal class III beta-tubulin in astrocytomas. Arch Pathol Lab Med 2001;125:613-24
33. Katsetos CD, Legido A, Perentes E, et al. Class III beta-tubulin isotype: A key cytoskeletal protein at the crossroads of developmental neuro-biology and tumor neuropathology. J Child Neurol 2003;18:851-66
34. Laggner U, Pipp I, Budka H, et al. Immunohistochemical detection of class III beta-tubulin in primary brain tumours: Variable expression in most tumour types limits utility as a differential diagnostic marker. His-topathology 2007;50:949-52
35. Blumcke I, Becker AJ, Normann S, et al. Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells. J Neuropathol Exp Neurol 2001;60:984-93
36. Blumcke I, Muller S, Buslei R, et al. Microtubule-associated protein-2 immunoreactivity: A useful tool in the differential diagnosis of low-grade neuroepithelial tumors. Acta Neuropathol 2004;108:89-96
37. Preusser M, Laggner U, Haberler C, et al. Comparative analysis of NeuN immunoreactivity in primary brain tumours: Conclusions for rational use in diagnostic histopathology. Histopathology 2006;48:438-44
38. Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell 1999;98:769-78
39. Hong YK, Detmar M. Prox1, master regulator of the lymphatic vasculature phenotype. Cell Tissue Res 2003;314:85-92
40. Johannessen AL, Torp SH. The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas. Pathol Oncol Res 2006;12:143-47
41. Piepmeier JM. Current concepts in the evaluation and management of WHO grade II gliomas. J Neurooncol 2009;92:253-59
42. Schittenhelm J, Mittelbronn M, Nguyen TD, et al. WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes. Brain Pathol 2008;18:344-53
43. Yaziji H, Massarani-Wafai R, Gujrati M, et al. Role of p53 immuno-histochemistry in differentiating reactive gliosis from malignant astro-cytic lesions. Am J Surg Pathol 1996;20:1086-90
44. Hirata J, Nakagoshi H, Nabeshima Y, et al. Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Nature 1995;377:627-30
45. Knoblich JA, Jan LY, Jan YN. Asymmetric segregation of Numb and Prospero during cell division. Nature 1995;377:624-27
46. Vaessin H, Grell E, Wolff E, et al. Prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 1991;67:941-53
47. Varghese M, Olstorn H, Sandberg C, Vik-Mo EO, et al. A comparison between stem cells from the adult human brain and from brain tumors. Neurosurgery 2008;63:1022-33