Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR γ through JNK-dependent upregulation of iNOS

Cellular and Molecular Life Sciences

Volumn 67, Issue 3, 2010, Pages 467-481

  Lee, Jongsung ^a   Jung, Eunsun ^a   Lee, Jienny ^a,b   Huh, Sungran ^a   Kim, Young Soo ^a,b   Kim, Yong Woo ^a   Kim, Yeong Shik ^a   Park, Deokhoon ^a  

^a Biospectrum Life Science Institute   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

3T3 L1 adipocytes; Adipocyte differentiation; INOS; JNK; PPAR

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CD36 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MERCAPTOPURINE RIBOSIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN C JUN;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; UPREGULATION;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; ANTHRACENES; ANTIMETABOLITES, ANTINEOPLASTIC; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; DOWN-REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MICE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PPAR GAMMA; STEM CELLS; THIOINOSINE; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 75849155786     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0196-y     Document Type: Article

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