Hypericum perforatum L. (St John's Wort) extract Ze 117 inhibits dopamine re-uptake in rat striatal brain slices. An implication for use in smoking cessation treatment?

Phytotherapy Research

Volumn 24, Issue 2, 2010, Pages 249-251

  Ruedeberg, C ^a   Wiesmann, U N ^a   Brattstroem, A ^b   Honegger, U E ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Max Zeller Sohne AG   (Switzerland)

Author keywords

Antidepressants; Dopamine; Neurotransmitter re uptake; Rat striatal brain slices; Smoking cessation; St. John's wort extract Ze 117

Indexed keywords

DOPAMINE; HYPERICUM PERFORATUM EXTRACT; NORADRENALIN; SEROTONIN;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN SLICE; BRAIN SYNAPTOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPRESSION; DOPAMINE UPTAKE; DOPAMINERGIC TRANSMISSION; DRUG DEPENDENCE; DRUG INHIBITION; DRUG POTENCY; FEMALE; FRONTAL CORTEX; HYPERICUM PERFORATUM; MEDICINAL PLANT; NONHUMAN; RAT; SMOKING CESSATION; TOBACCO DEPENDENCE;

ANIMALS; ANTIDEPRESSIVE AGENTS; CEREBRAL CORTEX; CORPUS STRIATUM; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPERICUM; NOREPINEPHRINE; PLANT EXTRACTS; RATS; RATS, WISTAR; SEROTONIN;

HYPERICUM PERFORATUM; RATTUS;

EID: 75849132571     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2921     Document Type: Article

References (13)

1. Annels FJ, Ellis Y, Davies JA. 1991. Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices. Brain Res 564: 341-343.
2. Barnes J, Barber N, Wheatley D, Williamson EM. 2006. A pilot randomised, open, uncontrolled, clinical study of two dosages of St John's wort (Hypericum perforatum) herb extract (Li-160) as an aid to motivational/behavioural support in smoking cessation. Planta Med 72: 378-382.
3. Becker B, Bock B, Carmona-Barros R. 2003. St John's wort oral spray reduces withdrawal symptoms during quitting smoking cessation. In Society for Research on Nicotine and Tobacco 9th Annual Meeting; New Orleans, Louisana. USA (Abstract).
4. Benowitz NL. 2008. Neurobiology of nicotine addiction: implications for smoking cessation treatment. Am J Med 121: S3-S10.
5. David SP, Munafo MR. 2008. Genetic variation in the dopamine pathway and smoking cessation. Pharmacogenomics 9: 1307-1321.
6. Fehr C, Yakushev I, Hohmann N et al. 2008. Association of low striatal dopamine D2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. Am J Psychiatry 165: 507-514.
7. Hatsukami DK, Stead LF, Gupta PC. 2008. Tobacco addiction. Lancet 371: 2027-2038.
8. Kientsch U, Bürgi S, Ruedeberg C, Probst S, Honegger UE. 2001. St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces β-adrenoceptor numbers on cultured rat brain cells. Pharmacopsychiatry 34 (Suppl. 1): 56-60.
9. rd International Congress, Sydney, Australia (Abstract), 31.
10. Lawvere S, Mahoney MC, Cummings KM et al. 2006. A Phase II study of St John's Wort for smoking cessation. Complement Ther Med 14: 175-184.
11. Müller WE, Rolli M, Schäfer C, Hafner U. 1997. Effects of hypericum extract (Li160) in biochemical models of antidepressant activity. Pharmacopsychiatry 30 (Suppl.): 102-107.
12. Perona MTG, Waters S, Hall FS et al. 2008. Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. Behav Pharmacol 19: 566-574.
13. Uzbay TI. 2008. Hypericum perforatum and substance dependence: a review. Phytother Res 22: 578-582.