New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear [Pd(II),K(I)]Polymer: DNA cleavage and cytotoxicity in vitro

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 1034-1041

  Gao, En Jun ^a   Zhu, Ming Chang ^a   Huang, Yun ^a   Liu, Lei ^a   Liu, Hong Yan ^a   Liu, Fu Chun ^a   Ma, Shuang ^a   Shi, Chun Yue ^a  

^a SHENYANG UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

Cytotoxic activity; DNA cleavage; Pd(II) Complexes; pH dependent products

Indexed keywords

CISPLATIN; MONOMER; PALLADIUM COMPLEX; PLASMID DNA; POLYMER; PYRIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PH; COMPLEX FORMATION; CONTROLLED STUDY; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MONONUCLEAR CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DNA CLEAVAGE; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; PALLADIUM;

EID: 75849129605     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.048     Document Type: Article

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