Lesions in the larynx of Wistar RccHan™: WIST rats

Journal of Toxicologic Pathology

Volumn 22, Issue 4, 2009, Pages 229-246

  Weber, Klaus ^a   Germann, Paul Georg ^b   Iwata, Hijiri ^a   Hardisty, Jerry ^c   Kaufmann, Wolfgang ^d   Rosenbruch, Martin ^e  

^a Harlan   (Switzerland)

^b Nycomed GmbH   (Germany)

^c EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^d BASF SE   (Germany)

^e BAYER PHARMA AG   (Germany)

Author keywords

Induced laryngeal lesions; Spontaneous laryngeal lesions; Wistar RccHan : WIST

Indexed keywords

XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CARCINOGENICITY; CONTROLLED STUDY; DEGENERATION; DISEASE SEVERITY; EDEMA; FOREIGN BODY; GRANULOMA; HISTOPATHOLOGY; INCIDENCE; INFLAMMATION; LARYNGOPHARYNGEAL REFLUX; LARYNX INJURY; LARYNX MUCOSA; MALE; MINERALIZATION; NECROSIS; NONHUMAN; RAT; RESPIRATORY EPITHELIUM; REVIEW; RODENT; SQUAMOUS CELL METAPLASIA; SUBMUCOSA; TISSUE SECTION; WISTAR RAT;

EID: 75749157716     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.22.229     Document Type: Review

References (46)

1. Renne RA, Gideon KM, Miller RA, Mellick PW, and Grumbein SL. Histologic methods and interspecies variations in the laryngeal histology of F344/N rats and B6C3F1 mice. Toxicol Pathol. 20: 44-51. 1992.
2. Renne RA, Sagartz JW, and Burger GT. Interspecies variations in the histology of toxicologically important areas in the larynges of CRL:CD rats and Syrian golden hamsters. Toxicol Pathol. 21: 542-546. 1993.
3. Renne RA and Gideon KM. Types and patterns of response in the larynx following inhalation. Toxicol Pathol. 34: 281-285. 2006.
4. Renne RA and Gideon KM, Harbo SJ, Staska LM, and Grumbein SL. Upper respiratory tract lesions in inhalation toxicology. Toxicol Pathol. 35: 163-169. 2007.
5. Sagartz JW, Madarasz AJ, Forsell MA, Burger GT, Ayres PH, and Coggins CRE. Histological sectioning of the rodent larynx for inhalation toxicity testing. Toxicol Pathol. 20: 118-121. 1992.
6. Lewis DJ. Morphological assessment of pathological changes within the rat larynx. Toxicol Pathol. 19: 352-357. 1991.
7. Germann PG, Ockert D, and Heinrichs M. Pathology of the oropharyngeal cavity in six strains of rats: predisposition of Fischer 344 rats for inflammatory and degenerative changes. Toxicol Pathol. 26: 283-289. 1998.
8. Kittel B, Ruehl-Fehlert C, Morawietz G, Klapwijk J, Elwell MR, Lenz B, O'Sullivan MG, Roth DR, and Wadsworth PF; RITA Group; NACAD Group. Revised guides for organ sampling and trimming in rats and mice - Part 2. A joint publication of the RITA and NACAD groups. Exp Toxicol Pathol. 55: 413-431. 2004.
9. Germann PG and Ockert D. Granulomatous inflammation of the oropharyngeal cavity as a possible cause for unexpected high mortality in a Fischer 344 rat carcinogenicity study. Lab Anim Sci. 44: 338-343. 1994.
10. Germann PG, Ockert D, and Tuch K. Oropharyngeal granulomas and tracheal cartilage degeneration in Fischer-344 rats. Toxicol Pathol. 23: 349-355. 1995.
11. Nagai H, Ota F, Konopacki R, and Connor NP. Discoordination of laryngeal and respiratory movements in aged rats. Am J Otolaryngol. 26: 377-382. 2005
12. Yamamoto Y, Tanaka S, Tsubone H, Atoji Y, and Suzuki Y. Age-related changes in sensory and secretomotor nerve endings in the larynx of F344/N rat. Arch Gerontol Geriatr. 36: 173-183. 2003.
13. McMullen CA and Andrade FH. Contractile dysfunction and altered metabolic profile of the aging rat thyroarytenoid muscle. J Appl Physiol. 100: 602-608. 2006.
14. Pontes P, Yamasaki R, and Behlau M. Morphological and functional aspects of the senile larynx. Folia Phoniatr Logop. 58: 151-158. 2006.
15. Valentine R, Frame S, and Kennedy G. Inhalation toxicology of fumed dodecanediamine. Inhal Toxicol. 16: 721-729. 2004.
16. National Toxicology Program. NTP toxicology and carcinogenesis studies of CS2 (94% o-Chlorobenzalmalononitrile, CAS No. 2698-41-1) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser. 377: 1-211. 1990.
17. National Toxicology Program. Toxicology and carcinogenesis studies of bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser. 363: 1-186. 1989.
18. National Toxicology Program. NTP toxicology and carcinogenesis studies of hexachlorocyclopentadiene (CAS No. 77-47-4) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser. 437: 1-308. 1994.
19. Marcelino FC and Oliveira DT. Histopathological changes of vocal folds induced by chronic pollutant exposure: an experimental study. J Voice. 19: 529-533. 2005.
20. Friedrichs B, Miert E and Vanscheeuwijck P. Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke. Exp Lung Res. 32: 151-79. 2006.
21. Duarte JL, de Faria FA, Ceolin DS, Cestari TM, and de Assis GF. Effects of passive smoke inhalation on the vocal cords of rats. Rev Bras Otorrinolaringol (Engl Ed). 72: 210-216. 2006.
22. O'Neill AJ, Ross PE, Elliott GS, Malley LA, and Kennedy GL Jr. Inhalation toxicity of dimethyl piperidinone. Toxicology. 183: 1-13. 2003.
23. National Toxicology Program. NTP toxicology and carcinogenesis studies of ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser. 440: 1-314. 1994.
24. Pauluhn J and Mohr U. Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats. J Appl Toxicol. 26: 279-292. 2006.
25. Işik AC, Kalender Y, Yardimci S, and Ergün A. Environmental tobacco smoke in rats. J Otolaryngol. 33: 382-386. 2004.
26. Maronian N, Haggitt R, Oelschlager BK, Bronner M, Yang J, Reyes V, Hillel A, Eubanks T, Pellegrini CA, and Pope CE 2nd. Histologic features of reflux-attributed laryngeal lesions. Am J Med. 115: 105S-108S. 2003.
27. Tsai TL, Chang SY, Ho CY, and Kou YR. Neural and hydroxyl radical mechanisms underlying laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats. J Appl Physiol. 101: 328-338. 2006.
28. Sasaki CT, Marotta J, Hundal J, Chow J, and Eisen RN. Bile-induced laryngitis: is there a basis in evidence? Ann Otol Rhinol Laryngol. 114: 192-197. 2005.
29. Haggitt RC. Histopathology of reflux-induced esophageal and supraesophageal injuries. Am J Med. 108: 109S-111S. 2000.
30. Ling ZG, Mukasiho K, Hidaka M, Chen KH, Yamamoto G, and Hattori T. Duodenal contents reflux-induced laryngitis in rats: possible mechanism of enhancement of the causative factors in laryngeal carcinogenesis.Ann Otol Rhnol. Laryngol. 116: 471-478. 2007.
31. Tateya T, Tateya I, Sohn JH, and Bless DM. Histologic characterization of rat vocal fold scarring. Ann Otol Rhinol Laryngol. 114: 183-191. 2005.
32. Tateya T, Tateya I, Sohn JH, and Bless DM. Histological study of acute vocal fold injury in a rat model. Ann Otol Rhinol Laryngol. 115: 285-292. 2006.
33. Bucher JR, Elwell M R, Thompson MB, Chou BJ, Renne RA, and Ragan HA. Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice. Fundam Appl Toxicol. 15: 357-372. 1990.
34. Bernfeld P, Homburger F, and Russfield AB. Strain differences in the respond of inbred Syrian hamsters to cigarette smoke inhalation. J Natl Cancer Inst. 53: 1141-1157. 1974.
35. Della Porta G, Kolb L, and Shubik P. Induction of tracheobronchial carcinomas in the Syrian olden hamsters. Cancer Res. 18: 592-597. 1958.
36. Dontenwill W. Tumorogenic effect of chronic cigarette smoke inhalation on Syrian Golden hamsters. In: Experimental Lung Cancer: Carcinogenesis and Bioassays. E Karbe and JF Park (eds). Springer-Verlag. New York. 331-359. 1972.
37. Dontenwill W, Chevalier HJ, Harke HP, LaFrenz U, Reckzeh G, and Schneider B. Investigations on the effects of chronic cigarette smoke inhalation in Syrian Golden hamsters. J Natl Canc Inst. 51: 1781-832. 1973.
38. Feron VJ, Kruysse A, and Woutersen RA. Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or dimethylnitrosamine. Eur J Cancer Clin Oncol. 18: 13-31. 1982.
39. Kaufman DG and Madison RM. Syngergistic effects of benzo(a)pyrene and N-methyl-N-nitrosourea on respiratory carcinogenesis in Syrian Golden hamsters. In: Experimental Lung Cancer: Carcinogenesis and Bioassays. E Karbe and JF Park (eds). Springer-Verlag. New York. 207-218. 1972.
40. Saffiotti U, Montesano R, Sellakumar AR, Cefis F, and Kaufman DG. Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. Cancer Res. 32: 1073-1081. 1972.
41. Homburger F. Smoker's larynx and carcinoma of the larynx in Syrian hamsters exposed to cigarette smoke. Laryngoscope. 85: 1874-1881. 1975.
42. Homburger F, Bernfeld P, and Russfield AB. Cigarette smoke inhalation studies in Syrian Golden hamsters. In: Experimental Lung Cancer: Carcinogenesis and Bioassays. E Karbe and JF Park (eds). Springer-Verlag. New York. 320-330. 1972.
43. Germann PG. Case 4. 10. Schnittseminar der Gesellschaft für Toxikologiosche Pathologie. Gent. 1996.
44. Schwartz LW, Hahn FF, Keenan KP, Keenan CM, Brown HR, and Mann PC. Proliferative lesions of the rat respiratory tract, R-1. In: Guides for Toxicologic Pathology. STP/ARP/AFIP. Washington, D.C. 1994.
45. Rosenbruch M and Kaufmann W. Aerosol-induced laryngeal squamous metaplasia. Class. Examples Tox. Pathology XV, University of Veterinary Medicine Hannover, 22-23. Feb. 2008.
46. Kaufmann W, Bader R, Ernst H, Harada T, Hardisty J, Kittel B, Kolling A, Pino M, Renne R, Rittinghausen S, Schulte A, Wöhrmann T, and Rosenbruch M. "Larynx squamous metaplasia": A re-consideration of morphology and diagnostic approaches in rodent studies and its relevance for human risk assessment. Exp Toxicol Path, in press. 2009.