Evaluation of supercritical fluid engineered budesonide powder for respiratory delivery using nebulisers

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 12, 2009, Pages 1625-1630

  Amani, Amir ^a,b   Chrystyn, Henry ^c   Clark, Brian J ^a   Abdelrahim, Mohamed E ^a,d   York, Peter ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

^d Beni Suef University   (Egypt)

Author keywords

Budesonide; In vitro aerosolisation characteristics; Nebuliser; SEDS; Supercritical fluid

Indexed keywords

BUDESONIDE; POLYSORBATE 80;

AEROSOL; ARTICLE; DRUG DELIVERY SYSTEM; DRY POWDER; NEBULIZATION; NEBULIZER; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SUPERCRITICAL FLUID;

EID: 75749156655     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.12.0006     Document Type: Article

References (21)

1. Mehta D. British National Formulary, 51st edn, electronic edition. London: Pharmaceutical Press, 2006.
2. Knoch M, Keller M. The customized electronic nebuliser: a new category of liquid aerosol drug delivery systems. Expert Opin Drug Deliv 2005; 2: 377-390.
3. Patravale VB et al. Nanosuspensions: a promising drug delivery strategy. J Pharm Pharmacol 2004; 56: 827-840.
4. Young PM et al. The influence of relative humidity on the cohesion properties of micronized drugs used in inhalation therapy. J Pharm Sci 2004; 93: 753-761.
5. Rehman M et al. Optimisation of powders for pulmonary delivery using supercritical fluid technology. Eur J Pharm Sci 2004; 22: 1-17.
6. Ward GH, Schultz RK. Process-induced crystallinity changes in albuterol sulphate and its effect on powder physical stability. Pharm Res 1995; 12: 773-779.
7. Nikander K et al. The conventional ultrasonic nebulizer proved inefficient in nebulizing a suspension. J Aerosol Med 1999; 12: 47-53.
8. York P et al. Supercritical fluid technology for drug product development. USA: Marcel Dekker, 2004.
9. Bisrat M, Moshashaee S. Composition comprising finely divided, crystalline particles of budesonide. European Patent EP1005328, 08 Jun, 2003.
10. Velaga SP et al. Stability and aerodynamic behaviour of glucocorticoid particles prepared by a supercritical fluids process. Eur J Pharm Sci 2004; 21: 501-509.
11. Schiavone H et al. Evaluation of SCF-engineered particle-based lactose blends in passive dry powder inhalers. Int J Pharm 2004; 281: 55-66.
12. Lobo JM et al. SCF-engineered powders for delivery of budesonide from passive DPI devices. J Pharm Sci 2005; 94: 2276-2288.
13. Dhand R. Nebulizers that use a vibrating mesh or plate with multiple apertures to generate aerosol. Resp Care 2002; 47: 1406-1416.
14. Frijlink HW, de Boer AH. Trends in the technology-driven development of new inhalation devices. Drug Discov Today 2005; 2: 47-57.
15. Fink JB et al. Comparison of a nebulizer using a novel aerosol generator with a standard ultrasonic nebulizer designed for use during mechanical ventilation. American Thoracic Society 97th International Conference. San Francisco, USA, 2001.
16. York P, Hanna M. Particle engineering by supercritical fluid technologies for powder inhalation drug delivery. Respiratory Drug Delivery V Proceedings. USA: Interpharm Press, 1996, 251-259.
17. CEN European Committee for Standardization. Respiratory therapy equipment - Part 1: nebulizing systems and their components, 2001.
18. Silkstone VL et al. An investigation of in-vitro/in-vivo correlations for salbutamol nebulised by eight systems. J Aerosol Med 2002; 15: 251-259.
19. Vaghi A et al. In vitro comparison of nebulised budesonide (Pulmicort Respules) and beclomethasone dipropionate (Clenil per Aerosol). Pulm Pharmacol 2005; 18: 151-153.
20. Riedler J, Robertson CF. Effect of tidal volume on the output and particle size distribution of hypertonic saline from an ultrasonic nebulizer. Eur Resp J 1994; 7: 998-1002.
21. Abdelrahim ME, Chrystyn H. Aerodynamic characteristics of nebulized terbutaline sulphate using the Next Generation Impactor (NGI) and CEN method. J Aerosol Med Pulm Drug Deliv 2009; 22: 19-28.