Cytotoxic activity of Catharanthus roseus (Apocynaceae) crude extracts and pure compounds against human colorectal carcinoma cell line

International Journal of Pharmacology

Volumn 6, Issue 1, 2010, Pages 43-47

  Siddiqui, M J ^a   Ismail, Z ^a   Aisha, A F A ^a   Abdul Majid, A M S ^a  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

Author keywords

Alkaloids; Catharanthine; Catharanthus roseus; Cytotoxicity; Vindoline

Indexed keywords

CATHARANTHINE; CATHARANTHUS ROSEUS EXTRACT; CHLOROFORM; HEXANE; METHANOL; VINDOLINE; WATER;

ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50;

EID: 75749141747     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2010.43.47     Document Type: Article

References (19)

1. Chattopadhyay, R.R., S.K. Sarkar, S. Ganguly, R.N. Banerjee and T.K. Basu, 1991. Hypoglycemic and antihyperglycemic effects of leaves of Vinca rosea Linn. Ind. J. Physiol. Pharmacol., 35: 145-151.
2. Chattopadhyay, R.R., R.N. Banerjee, S.K. Sarkar, S. Ganguly and T.K. Basti, 1992. Anti-inflammatory and acute toxicity studies with leaves of Vinca rosea Linn in experimental animals. Indian J. Physiol. Pharmacol., 36: 291-292.
3. Chattopadhyay, R.R., 1999. A comparative evaluation of some blood sugar lowering agents of plant origin. J. Ethanopharmacol., 67: 367-372.
4. El-Sayed, A. and G.A. Cordell, 1981. Catharanthus alkaloids. XXXIV. Catharanthamine, new antitumor bisindole alkaloids from Catharanthus roseus. J. Nat. Prod., 44: 289-293.
5. El-Sayed, A., G.A. Handy and G.A. Cordell, 1983. Catharanthus alkaloids XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N'b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus. J. Nat. Prod., 46: 517-527.
6. Ghosh, R.K. and I. Gupta, 1980. Effect of Vinca rosea and ficus racemososus on hyperglycemia in rats. Indian J. Anim. Health, 19: 145-148.
7. Gorman, M., N. Neuss and K. Biemann, 1962. Vinca alkaloids X, structure of Vindoline. J. Am. Chem. Soc., 84: 1058-1059.
8. Gorman, M., N. Neuss and N.J. Cone, 1965. Vinca Alkaloids, XVII, Chemistry of Catharanthine. J. Am. Chem. Soc., 87: 93-99.
9. Johnson, I.S., J.G. Armstrong, M. Gorman and J.P. Burnett, 1963. The vinca alkaloids: A new class of oncolytic agents. Cancer Res., 23: 1390-1427.
10. Mosmann, T., 1983. Rapid calorimetric assay for cellular growth and survival application to proliferation and cytotoxicity assays. J. Immunol. Method, 65: 55-63.
11. Mukhopadhyay, S. and G.A. Cordell, 1981. Catharanthus alkaloids XXXVI isolation of vincaleukoblastine (VLB) and periformyline from Catharanthus trichophyllus and pericyclivine from Catharanthus roseus. J. Nat. Prod., 44: 335-339.
12. Nobili, S., D. Lippi, E. Witort, M. Donnini, L. Bausi, E. Mini and S. Capaccioli, 2009. Natural compounds for cancer treatment and prevention. Pharmacol. Res., 59: 365-378.
13. Padua, De L.S., N. Bunyapraphatsara and R.H.M.J. Lemmens, 1999. Plant Resources of Southeast Asia. Prosea Foundation, Bogor, Indonesia, 12: 411-412.
14. Sapi, J. and G. Massiot, 1994. Heterocyclic Compounds. In: Monoterpenoids Indole Alkaloids, Part 4, Saxton, J.E. (Ed.). Wiley, Chichester, pp: 523-646.
15. Singh, S.N., P. Vats, S. Suri, R. Shyam and M.M. Kumria et al., 2001. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J. Ethnopharmacol., 76: 269-277.
16. Taylor, W.I. and N.R. Farnsworth, 1975. The Catharanthus Alkaloids: Botany, Chemistry, Pharmacology and Clinical Use. 1st Edn., Marcel Dekker Inc., New York, USA.
17. Ueda, J.Y., Y. Tezuka, A.H. Banskota, Q. Le Tran and Q.K. Tran et al., 2002. Antiproliferative activity of Vietnamese medicinal plants. Biol. Pharm. Bull., 25: 753-760.
18. Verma, A., I. Laakso, T. Seppanen-Laakso, A. Huhtikangas and M. Riekkola, 2007. A simplified procedure for indole alkaloids extraction from catharanthus roseus combined with a semi-synthetic production process for vinblastine. Molecules, 12: 1307-1315.
19. Williams, C.A. and R.J. Grayer, 2004. Anthocyanins and other flavonoids. Nat. Prod. Rep., 21: 539-573.