Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model

Lasers in Surgery and Medicine

Volumn 42, Issue 1, 2010, Pages 38-44

  Dai, Tianhong ^a,b   Tegos, George P ^a,b   Zhiyentayev, Timur ^a,c   Mylonakis, Eleftherios ^a   Hamblin, Michael R ^a,b,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

Bioluminescence imaging; Fluorescence imaging; Mouse model; MRSA; Photodynamic therapy; Skin abrasion; Wound infection

Indexed keywords

PHOTOSENSITIZING AGENT; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; BLEACHING; CONTROLLED STUDY; FEMALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SKIN ABRASION; WEIGHT REDUCTION; WOUND HEALING; WOUND INFECTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, INBRED BALB C; PHOTOBLEACHING; PHOTOCHEMOTHERAPY; POLYETHYLENEIMINE; PORPHYRINS; RADIATION-SENSITIZING AGENTS; STAPHYLOCOCCAL SKIN INFECTIONS; WOUND INFECTION;

EID: 75749135737     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.20887     Document Type: Article

References (22)

1. Herold BC, Immergluck LC, Maranan MC, Lauderdale DS, Gaskin RE, Boyle-Vavra S, Leitch CD, Daum RS. Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA 2008;279:593-598.
2. Chambers HF. The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis 2001;7:178-182.
3. Zervos M. Treatment options for uncomplicated community-acquired skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus: Oral antimicrobial agents. Surg Infect (Larchmt) 2008;9:s29-s34.
4. Vandenesch F, Naimi T, Enright MC, Lina G, Nimmo GR. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: Worldwide emergence. Emerg Infect Dis 2003;9:978-984.
5. Diep BA, Otto M. The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol 2008;16:361-369.
6. Bowers AL, Huffman GR, Sennett BJ. Methicillin-resistant Staphylococcus aureus infections in collegiate football players. Med Sci Sports Exerc 2008;40:1362-1367.
7. Philadelphia High School Football Player Dies of MRSA Infection. Accessed September 2009. http://cherryhill.injuryboard.com/.
8. Turbeville SD, Cowan LD, Greenfield RA. Infectious disease outbreaks in competitive sports: A review of the literature. Am J Sports Med 2006;34:1860-1865.
9. Hamblin MR, Hasan T. Photodynamic therapy: A new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004;3:436-450.
10. Jori G. Photodynamic therapy of microbial infections: State of the art and perspectives. J Environ Pathol Toxicol Oncol 2006;25:505-519.
11. Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR. Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J Photochem Photobiol B 2005;81:15-25.
12. Thorn RM, Nelson SM, Greenman J. Use of a bioluminescent Pseudomonas aeruginosa strain within an in vitro microbiological system, as a model of wound infection, to assess the antimicrobial efficacy of wound dressings by monitoring light production. Antimicrob Agents Chemother 2007;51: 3217-3224.
13. Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Hawkinson MJ, Xiao G, Purchio TF, Caparon MG, Lipsitch M, Contag PR. Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect Immun 2001;69:3350-3358.
14. Tegos GP, Anbe M, Yang C, Demidova TN, Satti M, Mroz P, Janjua S, Gad F, Hamblin MR. Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother 2006;50:1402-1410.
15. Habeeb AF. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal Biochem 1966;14:328-336.
16. Davis PJ, Rabinowitz P. Methods of numerical integration. New York: Academic Press; 1975. 459.
17. Peto R, Peto J. Asymptotically efficient rank invariant test procedures. J Royal Stat Soc A 1972;135:185-207.
18. James GA, Swogger E, Wolcott R, Pulcini E, Secor P, Sestrich J, Costerton JW, Stewart PS. Biofilms in chronic wounds. Wound Repair Regen 2008;16:37-44.
19. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004;34:426-438.
20. Schierle CF, De la Garza M, Mustoe TA, Galiano RD. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair Regen 2009;17:354-359.
21. Ma LW, Moan J, Berg K. Comparison of the photo-bleaching effect of three photosensitizing agents: Meso-tetra(mhydroxyphenyl) chlorin, meso-tetra(m-hydroxyphenyl)porphyrin and photofrin during photodynamic therapy. Lasers Med Sci 1994;9:127-132.
22. Plaetzer K, Krammer B, Berlanda J, Berr F, Kiesslich T. Photophysics and photochemistry of photodynamic therapy: Fundamental aspects. Lasers Med Sci 2009;24: 259-268.