Reliability of chromogenic in situ hybridization for epidermal growth factor receptor gene copy number detection in non-small-cell lung carcinomas: A comparison with fluorescence in situ hybridization study

Lung Cancer

Volumn 67, Issue 3, 2010, Pages 301-305

  Yoo, Seol Bong ^a   Lee, Hyun Ju ^a   Park, Jung Ok ^b   Choe, Gheeyoung ^a,b   Chung, Doo Hyun ^a   Seo, Jeong Wook ^a   Chung, Jin Haeng ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

Chromogenic in situ hybridization; EGFR; Fluorescence in situ hybridization; Non small cell carcinoma; Reproducibility

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

AGED; ARTICLE; CANCER DIAGNOSIS; CHROMOGENIC IN SITU HYBRIDIZATION; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE NUMBER; HISTOLOGY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTERMETHOD COMPARISON; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RELIABILITY;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CHROMOGENIC COMPOUNDS; FEMALE; FORMALDEHYDE; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; IN SITU HYBRIDIZATION; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; PARAFFIN EMBEDDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPRODUCIBILITY OF RESULTS; TISSUE FIXATION;

EID: 75749132379     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2009.05.002     Document Type: Article

References (11)

1. Feinstein M.B., and Bach P.B. Epidemiology of lung cancer. Chest Surg Clin N Am 10 (2000) 653-661
2. Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 (2004) 2129-2139
3. Cappuzzo F., Hirsch F.R., Rossi E., Bartolini S., Ceresoli G.L., Bemis L., et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97 (2005) 643-655
4. Hirsch F.R., Varella-Garcia M., Cappuzzo F., McCoy J., Bemis L., Xavier A.C., et al. Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. Ann Oncol 18 (2007) 752-760
5. Chang J.W., Liu H.P., Hsieh M.H., Fang Y.F., Hsieh M.S., Hsieh J.J., et al. Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: A chromogenic in situ hybridization study of 182 patients. Lung Cancer 61 (2008) 328-339
6. Gallegos Ruiz M.I., Floor K., Vos W., Grunberg K., Meijer G.A., Rodriguez J.A., et al. Epidermal growth factor receptor (EGFR) gene copy number detection in non-small-cell lung cancer; a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization. Histopathology 51 (2007) 631-637
7. Tanner M., Gancberg D., Di Leo A., Larsimont D., Rouas G., Piccart M.J., et al. Chromogenic in situ hybridization: a practical alternative for fluorescence in situ hybridization to detect HER-2/neu oncogene amplification in archival breast cancer samples. Am J Pathol 157 (2000) 1467-1472
8. Lambros M.B., Natrajan R., and Reis-Filho J.S. Chromogenic and fluorescent in situ hybridization in breast cancer. Hum Pathol 38 (2007) 1105-1122
9. In: Travis W.D., Brambilla E., Muller-Hermeling H.K., and Harris CC (Eds). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization classification of Tumours (2004), IARC Press, Lyon
10. Hirsch F.R., Herbst R.S., Olsen C., Chansky K., Crowley J., Kelly K., et al. Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol 26 (2008) 3351-3357
11. Jeon Y.K., Sung S.W., Chung J.H., Park W.S., Seo J.W., Kim C.W., et al. Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer. Lung Cancer 54 (2006) 387-398