Exercise-associated hyponatremia with rhabdomyolysis during endurance exercise

Physician and Sportsmedicine

Volumn 37, Issue 1, 2009, Pages 126-132

  Ellis, Christopher ^a   Cuthill, Jennifer ^b   Hew Butler, Tamara ^c   George, Sajid Melvin ^d   Rosner, Mitchell H ^d  

^a Stobhill Hospital ^*

^b ARIZONA STATE UNIVERSITY   (United States)

^c Carillion Health System   (United States)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Exercise; Hyponatremia; Rhabdomyolysis

Indexed keywords

ARGIPRESSIN; CREATINE KINASE; MANNITOL; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM CHLORIDE; DIURETIC AGENT; FUROSEMIDE;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; ATHLETE; CASE REPORT; CREATINE KINASE BLOOD LEVEL; DIARRHEA; ENDURANCE; EXERCISE; FEMALE; HUMAN; HYPONATREMIA; MALE; PATHOGENESIS; RHABDOMYOLYSIS; SEIZURE; SKELETAL MUSCLE; SODIUM BLOOD LEVEL; URINE OSMOLALITY; VOMITING; FLUID THERAPY; METHODOLOGY; MIDDLE AGED; RUNNING;

ADULT; DIURETICS; FEMALE; FLUID THERAPY; FUROSEMIDE; HUMANS; HYPONATREMIA; MALE; MIDDLE AGED; PHYSICAL ENDURANCE; RHABDOMYOLYSIS; RUNNING;

EID: 75749088883     PISSN: 00913847     EISSN: None     Source Type: Journal    
DOI: 10.3810/PSM.2009.04.1693     Document Type: Article

References (26)

1. Noakes TD, Goodwin N, Rayner BL, Branken T, Taylor RK. Water intoxication: a possible complication during endurance exercise. Med Sci Sports Exerc. 1985;17(3):370-375.
2. Rosner MH, Kirven J. Exercise-associated hyponatremia. Clin J Am Soc Nephrol. 2007;2(1):151-161.
3. Rosner, MH. Exercise-associated hyponatremia. Phys Sportsmed. 2008;36:55-61.
4. Almond, CS, Shin, AY, Fortescue, EB, et al. Hyponatremia among runners in the Boston Marathon. N Engl J Med . 2005;352(15):1550-1556.
5. Hew-Butler T, Ayns JC, Kipps C, et al. Statement of the Second International Exercise-Associated Hyponatremia Consensus Development Conference, New Zealand, 2007. Clin J Sport Med . 2008;18(2):111-121.
6. Putterman C, Levy L, Rubinger D. Transient exercise-induced water intoxication and rhabdomyolysis. Am J Kidney Dis . 1993;21(2):206-209.
7. Sidi Y, Gassner S, Sandbank U, Keren G, Pinkhas J. Water intoxication, hyperpyrexia and rhabdomyolysis in a patient with psychogenic polydipsia. N Y State J Med . 1984;84(9):462-464.
8. Mor F, Mor-Snir I, Wysenbeek AJ. Rhabdomyolysis in self-induced water intoxication. J Nerv Ment Dis . 1987;175(12)742-743.
9. Korzets A, Ori Y, Floro S, et al. Case report: severe hyponatremia after water intoxication: a potential cause of rhabdomyolysis. Am J Med Sci . 1996;312(2):92-94.
10. Mitnick PD, Bell S. Rhabdomyolysis associated with severe hyponatremia after prostatic surgery. Am J Kidney Dis . 1990;16(1):73-75.
11. Egan JJ, Davies AJ, Jones MK, Hyponatremic rhabdomyolysis in Addison's disease. Postgrad Med J . 1994;70(829):830-832.
12. Trimarchi H, Gonzalez J, Olivero J. Hyponatremia-associated rhabdomyolysis. Nephron . 1999;82(3):274-277.
13. Sue YM, Lee YL, Huang JJ. Acute hyponatremia, seizure and rhabdomyolysis after ecstasy use. J Toxicol Clin Toxicol . 2002;40(7):931-932.
14. Knochel JP, Schlei EM. On the mechanism of rhabdomyolysis in potassium depletion. J Clin Invest . 1972;51(7):1750-1758.
15. Lang MA, Gainer H. Volume control by muscle fibers of the blue crab Volume readjustment in hypotonic salines. J Gen Physiol . 1969;53(3):323-341.
16. Sterns RH, Baer J, Ebersol S, Thomas D, Lohr JW, Kamm DE. Organic osmolytes in acute hyponatremia. Am J Physiol . 1993;264(5 pt 2):F833-F836.
17. Kilburn KH. Muscular origin of elevated plasma potassium during exercise. J Appl Physiol . 1966;21(2):675-678.
18. Rizzieri DA. Rhabdomyolysis after correction of hyponatremia due to psychogenic polydipsia. Mayo Clin Proc . 1995;70(5):473-476.
19. Wicki J, Rutschmann OT, Burri H, Vecchietti G, Desmeules J. Rhabdomyolysis after correction of hyponatremia due to psychogenic polydipsia possibly complicated by clozapine. Ann Pharmacother . 1998;32(9):892-895.
20. Zaidi A. Rhabdomyolysis after correction of hyponatremia in psychogenic polydipsia possibly complicated by ziprasidone. Ann Pharmacother . 2005;39(10):1726-1731.
21. Fulton RL, Ridolpho P. Physiologic effects of acute sodium depletion. Ann Surg . 1971;173(3):344-356.
22. Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev . 1999;79(3)763-854.
23. Goll DE, Thompson VF, Li H, Wei W, Cong J. The calpain system. Physiol Rev . 2003;83(3):731-801.
24. Knochel JP. Mechanisms of rhabdomyolysis. Curr Opin Rheumatol . 1993;5(6):725-731.
25. Huerta-Alardin AL, Varon J, Marik P. Bench-to-bedside review: rhabdomyolysis - an overview for clinicians. Crit Care . 2005;9(2):158-169.
26. Siegel AJ. Exercise-associated hyponatremia: role of cytokines. Am J Med . 2006;119(7 suppl 1):S74-S78.