Extracapsular lymph node spread: A new prognostic factor in gastric cancer

Cancer

Volumn 116, Issue 2, 2010, Pages 309-315

  Alakus, Hakan ^a   Hölscher, Arnulf H ^a   Grass, Guido ^a   Hartmann, Eva ^a   Schulte, Christian ^a   Drebber, Uta ^a   Baldus, Stephan E ^a   Bollschweiler, Elfriede ^a   Metzger, Ralf ^a   Mönig, Stefan P ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

D2 lymphadenectomy; Extracapsular lymph node involvement; Gastric carcinoma; Pathological staging; Prognosis

Indexed keywords

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; EXTRACAPSULAR LYMPH NODE METASTASIS; FEMALE; GASTRECTOMY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; STOMACH CANCER;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 75649152842     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.24764     Document Type: Article

References (25)

1. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49:33-64.
2. Siewert JR, Bottcher K, Stein HJ, Roder JD. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg. 1998;228:449-461.
3. Sanchez-Bueno F, Garcia-Marcilla JA, Perez-Flores D, et al. Prognostic factors in a series of 297 patients with gastric Adenocarcinoma undergoing surgical resection. Br J Surg. 1998;85:255-260.
4. Kim JP, Lee JH, Kim SJ, Yu HJ, Yang HK. Clinicopathologic characteristics and prognostic factors in 10 783 patients with gastric cancer. Gastric Cancer. 1998;1:125-133.
5. Yokota T, Ishiyama S, Saito T, et al. Lymph node metastasis as a significant prognostic factor in gastric cancer: a multiple logistic regression analysis. Scand J Gastroenterol. 2004;39:380-384.
6. Monig SP, Nolden B, Lubke T, et al. Clinical significance of nm23 gene expression in gastric cancer. Anticancer Res. 2007;27:3029-3033.
7. Japanese Gastric Cancer Association.Japanese classification of gastric carcinoma - 2nd English ed. Gastric Cancer. 1998;1:10-24.
8. Sobin LH, Wittekind CH. International Union Against Cancer (UICC). TNM Classification of Malignant Tumors. 5th ed. New York: John Wiley & Sons; 1997.
9. Roder JD, Bottcher K, Busch R, Wittekind C, Hermanek P, Siewert JR. Classification of regional lymph node metastasis from gastric carcinoma. German Gastric Cancer Study Group. Cancer. 1998;82:621-631.
10. Metzger R, Drebber U, Baldus SE, Monig SP, Holscher AH, Bollschweiler E. Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus. Ann Surg Oncol. 2009;16:447-453.
11. Lagarde SM, ten Kate FJ, de Boer DJ, Busch OR, Obertop H, van Lanschot JJ. Extracapsular lymph node involvement in node-positive patients with adenocarcinoma of the distal esophagus or gastroesophageal junction. Am J Surg Pathol. 2006;30:171-176.
12. Japanese Gastric Cancer Association.Japanese classification of gastric cancer. Gastric Cancer. 1998;1:25-30.
13. Wind J, Lagarde SM, Ten Kate FJ, Ubbink DT, Bemelman WA, van Lanschot JJ. A systematic review on the significance of extracapsular lymph node involvement in gastrointestinal malignancies. Eur J Surg Oncol. 2007;33:401-408.
14. Brasilino de Carvalho M. Quantitative analysis of the extent of extracapsular invasion and its prognostic significance: a prospective study of 170 cases of carcinoma of the larynx and hypopharynx. Head Neck. 1998;20:16-21.
15. Fisher BJ, Perera FE, Cooke AL, et al. Extracapsular axillary node extension in patients receiving adjuvant systemic therapy: an indication for radiotherapy?Int J Radiat Oncol Biol Phys. 1997;38:551-559.
16. Fleischmann A, Thalmann GN, Markwalder R, Studer UE. Prognostic implications of extracapsular extension of pelvic lymph node metastases in urothelial carcinoma of the bladder. Am J Surg Pathol. 2005;29:89-95.
17. Griebling TL, Ozkutlu D, See WA, Cohen MB. Prognostic implications of extracapsular extension of lymph node metastases in prostate cancer. Mod Pathol. 1997;10:804-809.
18. Myers JN, Greenberg JS, Mo V, Roberts D. Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer. 2001;92:3030-306.
19. Ishida T, Tateishi M, Kaneko S, Sugimachi K. Surgical treatment of patients with nonsmall-cell lung cancer and mediastinal lymph node involvement. J Surg Oncol. 1990;43:161-166.
20. van der Velden J, van Lindert AC, Lammes FB, et al. Extracapsular growth of lymph node metastases in squamous cell carcinoma of the vulva. The impact on recurrence and survival. Cancer. 1995;75:2885-2890.
21. Tanaka T, Kumagai K, Shimizu K, Masuo K, Yamagata K. Peritoneal metastasis in gastric cancer with particular reference to lymphatic advancement; extranodal invasion is a significant risk factor for peritoneal metastasis. J Surg Oncol. 2000;75:165-171.
22. Kumagai K, Tanaka T, Yamagata K, Yokoyama N, Shimizu K. Liver metastasis in gastric cancer with particular reference to lymphatic advancement. Gastric Cancer. 2001;4:150-155.
23. Nakamura K, Ozaki N, Yamada T, et al. Evaluation of prognostic significance in extracapsular spread of lymph node metastasis in patients with gastric cancer. Surgery. 2005;137:511-517.
24. Di Giorgio A, Botti C, Sammartino P, Mingazzini P, Flammia M, Stipa V. Extracapsular lymphnode metastases in the staging and prognosis of gastric cancer. Int Surg. 1991;76:218-221.
25. Okamoto T, Tsuburaya A, Kameda Y, et al. Prognostic value of extracapsular invasion and fibrotic focus in single lymph node metastasis of gastric cancer. Gastric Cancer. 2008;11:160-167.