Epithelial-mesenchymal transition in tumor metastasis: A method to the madness

Future Oncology

Volumn 5, Issue 8, 2009, Pages 1109-1111

  Keshamouni, Venkateshwar G ^a   Schiemann, William P ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST TUMOR; CANCER CLASSIFICATION; CANCER GROWTH; CELL DAMAGE; CELL DIFFERENTIATION; CELL INTERACTION; CELL MIGRATION; EDITORIAL; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; LIVER CELL CARCINOMA; METASTASIS; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; PUBLICATION; STROMA CELL;

ANIMALS; CELL DIFFERENTIATION; EPITHELIUM; HUMANS; MESODERM; METAPLASIA; NEOPLASM METASTASIS;

EID: 75649147719     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.09.87     Document Type: Editorial

References (22)

1. Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100, 57-70 (2000). ■■ Seminal review describing six hallmarks of a cancer cell.
2. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2, 442-454. (2002).
3. Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA: Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J. Clin. Invest. 119, 1438-1449 (2009).
4. Kalluri R, Weinberg RA: The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420-1428 (2009). ■ Proposed classification of the epithelial-mesenchymal transition (EMT) into three subtypes.
5. Yang J, Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 14, 818-829 (2008).
6. Thiery JP, Sleeman JP: Complex networks orchestrate epithelial- mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131-142 (2006).
7. Kudo-Saito C, Shirako H, Takeuchi T et al.: Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell. 15, 195-206 (2009). ■■ First paper to demonstrate that EMT also induces immunosuppression, along with enhanced invasion, to promote metastasis.
8. Tarin D, Thompson EW, Newgreen DF: The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 65, 5996-6000; discussion 6000-5991 (2005).
9. Kim KK, Kugler MC, Wolters PJ et al.: Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl Acad. Sci. USA 103, 13180-13185 (2006). ■ First paper to demonstrate in vivo EMT in the context of tissue fibrosis by tracking cell fate.
10. Trimboli AJ, Fukino K, de Bruin A et al.: Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res. 68, 937-945 (2008). ■ First in vivo evidence of EMT in the context of tumor progression in a mouse model of breast cancer.
11. Zeisberg M, Yang C, Martino M et al.: Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J. Biol. Chem. 282, 23337-23347 (2007).
12. Reckamp KL, Gardner BK, Figlin RA et al.: Tumor response to combination celecoxib and erlotinib therapy in non-small cell lung cancer is associated with a low baseline matrix metalloproteinase-9 and a decline in serum-soluble e-cadherin. J. Thorac. Oncol. 3, 117-124 (2008). ■ First correlation of EMT markers to therapeutic response in patients with lung cancer.
13. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110, 341-350 (2002). ■ First paper to demonstrate contribution of EMT to tissue fibrosis.
14. Dimeo TA, Anderson K, Phadke P et al.: Anovel lung metastasis signature links wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res. 69(13), 5364-5373 (2009).
15. Singh A, Greninger P, Rhodes D et al.: A gene expression signature associated with 'K-ras addiction' Reveals regulators of EMT and tumor cell survival. Cancer Cell 15, 489-500 (2009).
16. Thomson S, Buck E, Petti F et al.: Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal non receptor inhibition. Cancer Res. 65, 9455-9462 (2005).
17. Mani SA, Guo W, Liao MJ et al.: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008). ■■ First paper to demonstrate a link between EMT and stemness.
18. Lee JM, Dedhar S, Kalluri R, Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J. Cell Biol. 172, 973-981 (2006).
19. Micalizzi DS, Ford HL: Epithelial-mesenchymal transition in development and cancer. Future Oncol. 5(8), 1129-1143 (2009).
20. Radaelli E, Damonte P, Cardiff RD: Epithelial-mesenchymal transition in mouse mammary tumorigenesis. Future Oncol. 5(8), 1113-1127 (2009).
21. Wendt MK, Allington TM, Schiemann WP: Mechanisms of epithelial- mesenchymal transition by TGF-β. Future Oncol. 5(8), 1145-1168 (2009)
22. van Zijl F, Zulehner G, Petz M et al.: Epithelial-mesenchymal transition in hepatocellular carcinoma. Future Oncol. 5(8), 1169-1179 (2009).