Preoperative staging of rectal cancer

Future Oncology

Volumn 5, Issue 8, 2009, Pages 1295-1306

  Yeung, Justin M C ^a   Ferris, Nicholas J ^a   Lynch, A Craig ^a   Heriot, Alexander G ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

CT; Digital rectal examination; ERUS; MRI; PET; PET CT; Preoperative staging; Rectal cancer

Indexed keywords

CANCER STAGING; CLINICAL EXAMINATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DIGITAL RECTAL EXAMINATION; ECHOGRAPHY; ENDORECTAL ECHOGRAPHY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RECTUM CANCER; REVIEW; SENSITIVITY AND SPECIFICITY;

ENDOSONOGRAPHY; HUMANS; MAGNETIC RESONANCE IMAGING; NEOPLASM STAGING; POSITRON-EMISSION TOMOGRAPHY; PREOPERATIVE CARE; RECTAL NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 75649131818     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.09.100     Document Type: Review

References (127)

1. Office of Population Censuses and Surveys: Mortality Statistics; General. Review of the Registrar-General on Deaths in England and Wales, 1990. Series DH11. No 24. HMSO: 32. London, UK (1992).
2. American Cancer Society: Cancer Facts and Figures 2006. American Cancer Society, Atlanta, USA (2006).
3. Australian Institute of Health and Welfare (AIHW), Australasian Association of Cancer Registries (AACR), National Cancer Strategies Group (NCSG), McDermid I: Cancer incidence projections, Australia 2002 to 2011. Australian Institute of Health and Welfare, Canberra, Australia (2005).
4. Wibe A, Rendedal PR, Svensson E et al.: Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br. J. Surg. 89, 327-334 (2002).
5. Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK: Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch. Surg. 133, 894-899 (1998). ■ Examines the role of total mesorectal excision (TME) in the role of rectal cancer management, which has been adopted by colorectal surgeons.
6. Martling AL, Holm T, Rutqvist LE et al.: Effect of a surgical training program on outcome of rectal cancer in the County of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project. Lancet 356, 93-96 (2000).
7. Colorectal Cancer Collaborative Group: Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomized trials. Lancet 358, 1291-1304 (2001). ■ Meta-ana lysis showing that preoperative radiotherapy reduces rectal cancer recurrence.
8. Kapiteijn E, Marijnen CA, Nagtegaal ID et al.; Dutch Colorectal Cancer Group: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N. Engl. J. Med. 345, 638-646 (2001). ■ Short-course radiotherapy reduces the local recurrence rate in rectal cancer.
9. Sauer R, Becker H, Hohenberger W et al.; German rectal cancer study group: Preoperative versus postoperative chemoradiotherapy for rectal cancer. N. Engl. J. Med. 351, 1731-1740 (2004).
10. Swedish Rectal Cancer trial: Improved survival with preoperative radiotherapy in resectable rectal cancer. N. Engl. J. Med. 336, 980-987 (1997). ■ Found that a short-term regimen of high-dose preoperative radiotherapy reduces rates of local recurrence and improves survival among patients with resectable rectal cancer.
11. Sebag-Montefiore D, Stephens RJ, Steele R et al.: Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomized trial. Lancet 373(9666), 811-820 (2009). ■ Results of MRC-CR07 and NCIC-CTG C016. A large multicenter trial comparing short-course preoperative radiotherapy versus postoperative chemoradiotherapy. Preoperative radiotherapy improves disease-free survival and reduces local recurrence rates.
12. Heriot AG, Tekkis PP, Neary P et al.: Adjuvant radiotherapy is associated with increased sexual dysfunction in patients undergoing resection for rectal cancer - a predictive model. Ann. Surg. 242(4), 502-510 (2005).
13. Li WH, Cheung MT, Ho CNS, Fung TP, Ko KM, Yau KKW: Liver and lung resection for colorectal metastasis. Surgical Practice. 11, 138-143 (2007).
14. Smith A, Farmer KC, Chapple K: Clinical and endorectal ultrasound staging of circumferential rectal cancers. J. Med. Imaging Radiat. Oncol. 52(2),161-163 (2008).
15. Thumbe V, Iqbal M, Bhalerao S: Accuracy of digital rectal examination in the estimation of height of rectal lesions. Tech. Coloproctol. 11(2), 111-113 (2007).
16. Brown G, Davies S, Williams GT et al.: Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging? Br. J. Cancer 91(1), 23-29 (2004).
17. Schaffzin DM, Wong WD: Endorectal ultrasound in the preoperative evaluation of rectal cancer. Clin. Colorectal Cancer. 4(2), 124-132. (2004).
18. Beynon J, Foy DM, Temple LN, Channer JL, Virjee J, Mortensen NJ: The endosonic appearances of normal colon and rectum. Dis. Colon Rectum. 29(12), 810-813 (1986).
19. Hildebrandt U, Feifel G: Preoperative staging of rectal cancer by intrarectal ultrasound. Dis. Colon Rectum 28(1), 42-46 (1985).
20. Steele SR, Martin MJ, Place RJ: Flexible endorectal ultrasound for predicting pathologic stage of rectal cancers. Am. J. Surg. 184(2), 126-130 (2002).
21. Badger SA, Devlin PB, Neilly PJ, Gilliland R: Preoperative staging of rectal carcinoma by endorectal ultrasound: is there a learning curve? Int. J. Colorectal Dis. 22(10), 1261-1268 (2007).
22. Orrom WJ, Wong WD, Rothenberger DA, Jensen LL, Goldberg SM: Endorectal ultrasound in the preoperative staging of rectal tumors. A learning experience. Dis. Colon Rectum 33(8), 654-659 (1990). ■ Introduction of a five-layer anatomical model for interpreting the endorectal ultrasound appearances of the rectal wall.
23. McMullen TP, Easson AM, Cohen Z, Swallow CJ: The investigation of primary rectal cancer by surgeons: current pattern of practice. Can. J. Surg. 48(1), 19-26 (2005).
24. Huh JW, Park YA, Jung EJ, Lee KY, Sohn SK: Accuracy of endorectal ultrasonography and computed tomography for restaging rectal cancer after preoperative chemoradiation. J. Am. Coll. Surg. 207(1), 7-12 (2008).
25. Akasu T, Moriya Y, Sugihara K: Transrectal ultrasonography of a small rectal carcinoid tumor with lymph node metastasis: a case report. Jpn. J. Clin. Oncol. 26(2), 112-115 (1996).
26. Maier AG, Barton PP, Neuhold NR, Herbst F, Teleky BK, Lechner GL: Peritumoral tissue reaction at transrectal US as a possible cause of overstaging in rectal cancer: histopathologic correlation. Radiology 203(3), 785-789 (1997).
27. Koh DM, Brown G, Husband JE: Nodal staging in rectal cancer. Abdom. Imaging 31(6), 652-659 (2006).
28. Mackay SG, Pager CK, Joseph D, Stewart PJ, Solomon MJ: Assessment of the accuracy of transrectal ultrasonography in anorectal neoplasia. Br. J. Surg. 90, 346-350 (2003).
29. Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J: Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging - a meta-ana lysis. Radiology 232(3), 773-783 (2004). ■ A meta-ana lysis showing that endorectal ultrasound was most accurate in the assessment of local invasion.
30. Lahaye MJ, Engelen SM, Nelemans PJ et al.: Imaging for predicting the risk factors - the circumferential resection margin and nodal disease - of local recurrence in rectal cancer: a meta-ana lysis Semin. Ultrasound CT MR 26(4), 259-268 (2005).
31. Katsura Y, Yamada K, Ishizawa T, Yoshinaka H, Shimazu H: Endorectal ultrasonography for the assessment of wall invasion and lymph node metastasis in rectal cancer. Dis. Colon Rectum 35(4), 362-368 (1992).
32. Kim JC, Kim HC, Yu CS et al.: Efficacy of 3-dimensional endorectal ultrasonography compared with conventional ultrasonography and computed tomography in preoperative rectal cancer staging. Am. J. Surg. 192(1), 89-97 (2006).
33. Thoeni RF, Moss AA, Schnyder P, Margulis AR: Detection and staging of primary rectal and rectosigmoid cancer by computed tomography. Radiology 141(1), 135-138 (1981).
34. Grabbe E, Lierse W, Winkler R: The perirectal fascia: morphology and use in staging of rectal carcinoma. Radiology 149(1), 241-246 (1983). 35. van Waes PF, Koehler PR, Feldberg MA: Management of rectal carcinoma: impact of computed tomography. Am. J. Roentgenol. 140(6), 1137-1142 (1983).
35. Hodgman CG, MacCarty RL, Wolff BG et al.: Preoperative staging of rectal carcinoma by computed tomography and 0.15T magnetic resonance imaging. Preliminary report. Dis. Colon Rectum 29(7), 446-450 (1986).
36. Muthusamy VR, Chang KJ: Optimal methods for staging rectal cancer. Clin. Cancer Res. 13(22 Pt 2), 6877S-6884S (2007).
37. Vliegen R, Dresen R, Beets G et al.: The accuracy of multidetector row CT for the assessment of tumor invasion of the mesorectal fascia in primary rectal cancer. Abdom. Imaging 33(5), 604-610 (2008).
38. Wolberink SV, Beets-Tan RG, de Haas-Kock DF, van de Jagt EJ, Span MM, Wiggers T: Multislice CT as a primary screening tool for the prediction of an involved mesorectal fascia and distant metastases in primary rectal cancer: a multicenter study. Dis. Colon Rectum 52(5), 928-934 (2009).
39. Kim NK, Kim MJ, Yun SH, Sohn SK, Min JS: Comparative study of transrectal ultrasonography, pelvic computerized tomography, and magnetic resonance imaging in preoperative staging of rectal cancer. Dis. Colon Rectum 42, 770-775 (1999).
40. Yano H, Saito Y, Takeshita E, Miyake O, Ishizuka N: Prediction of lateral pelvic node involvement in low rectal cancer by conventional computed tomography. Br. J. Surg. 94(8), 1014-1019 (2007).
41. Brown G, Richards CJ, Bourne MW et al: Morphologic predictors of lymph node status in rectal cancer with use of high-spatialresolution MR imaging with histopathologic comparison. Radiology 227(2), 371-377 (2003). ■ Useful article illustrating the prediction of nodal involvement with magnetic resonance imaging (MRI) using boarder contour and signal intensity characteristics.
42. Cawthorn SJ, Gibbs NM, Marks CG: Clearance technique for the detection of lymph nodes in colorectal cancer. Br. J. Surg. 73(1), 58-60 (1986).
43. Jass JR, Love SB: Prognostic value of direct spread in Dukes' C cases of rectal cancer. Dis. Colon Rectum 32(6), 477-480 (1989).
44. Adam IJ, Mohamdee MO, Martin IG et al.: Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 344(8924), 707-711 (1994).
45. Hall NR, Finan PJ, al-Jaberi T et al.: Circumferential margin involvement after mesorectal excision of rectal cancer with curative intent. Predictor of survival but not local recurrence? Dis. Colon Rectum 41(8), 979-983 (1998).
46. Cova M, Frezza F, Pozzi-Mucelli RS et al.: Computed tomography and magnetic resonance in the preoperative staging of the spread of rectal cancer. A correlation with the anatomicopathological aspects. Radiol. Med. 87(1-2), 82-89 (1994).
47. Zerhouni EA, Rutter C, Hamilton SR et al.: CT and MR imaging in the staging of colorectal carcinoma: report of the Radiology Diagnostic Oncology Group II. Radiology 200(2), 443-451 (1996).
48. Guinet C, Buy JN, Ghossain MA et al.: Comparison of magnetic resonance imaging and computed tomography in the preoperative staging of rectal cancer. Arch. Surg. 125, 385-388 (1990).
49. Schnall MD, Furth EE, Rosato EF, Kressel HY: Rectal tumor stage: correlation of endorectal MR imaging and pathologic findings. Radiology 190, 709-714 (1994).
50. Gualdi GF, Casciani E, Guadalaxara A, d'Orta C, Polettini E, Pappalardo G: Local staging of rectal cancer with transrectal ultrasound and endorectal magnetic resonance imaging: comparison with histologic findings. Dis. Colon Rectum 43, 338-345 (2000).
51. Maldjian C, Smith R, Kilger A, Schnall M, Ginsberg G, Kochman M: Endorectal surface coil MR imaging as a staging technique for rectal carcinoma: a comparison study to rectal endosonography. Abdom. Imaging 25, 75-80 (2000).
52. Chan TW, Kressel HY, Milestone B et al.: Rectal carcinoma: staging at MR imaging with endorectal surface coil - work in progress. Radiology 181, 461-467 (1991).
53. Indinnimeo M, Grasso RF, Cicchini C et al.: Endorectal magnetic resonance imaging in the preoperative staging of rectal tumors. Int. Surg. 81, 419-422 (1996).
54. Zagoria RJ, Schlarb CA, Ott DJ et al.: Assessment of rectal tumor infiltration utilizing endorectal MR imaging and comparison with endoscopic rectal sonography. J. Surg. Oncol. 64, 312- 317 (1997).
55. Pegios W, Vogl J, Mack MG et al.: MRI diagnosis and staging of rectal carcinoma. Abdom. Imaging 21, 211-218 (1996).
56. Vogl TJ, Pegios W, Mack MG et al.: Accuracy of staging rectal tumors with contrast-enhanced transrectal MR imaging. Am. J. Roentgenol. 168, 1427-1434 (1997).
57. Hunerbein M, Pegios W, Rau B, Vogl TJ, Felix R, Schlag PM: Prospective comparison of endorectal ultrasound, three-dimensional endorectal ultrasound, and endorectal MRI in the preoperative evaluation of rectal tumors: preliminary results. Surg. Endosc. 14, 1005-1009 (2000).
58. Brown G, Radcliffe AG, Newcombe RG, Dallimore NS, Bourne MW, Williams GT: Preoperative assessment of prognostic factors in rectal cancer using high resolution MRI. Br. J. Surg. 90, 355-364 (2003).
59. MERCURY Study Group: Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology 243(1), 132-139 (2007).
60. Mercury Study Group: Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ 2006 333(7572), 779 (2006). ■ MRI can predict surgical circumferential resection margin involvement by tumor.
61. Heald RJ, Ryall RD: Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1(8496), 1479-1482 (1986).
62. Bissett IP, Fernando CC, Hough DM et al.: Identification of the fascia propria by magnetic resonance imaging. Dis. Colon Rectum 44, 259-265 (2001).
63. Purkayastha S, Tekkis PP, Athanasiou T, Tilney HS, Darzi AW, Heriot AG: Diagnostic precision of magnetic resonance imaging for preoperative prediction of the circumferential margin involvement in patients with rectal cancer. Colorectal Dis. 9(5), 402-411 (2007).
64. Günther K, Dworak O, Remke S et al.: Prediction of distant metastases after curative surgery for rectal cancer. J. Surg. Res. 103, 68-78 (2002).
65. Dworak O: Morphology of lymph nodes in the resected rectum of patients with rectal carcinoma. Pathol. Res. Pract. 187, 1020-1024 (1991).
66. Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG: High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur. J. Radio. 52(1), 78-83 (2004).
67. Lahaye MJ, Engelen SM, Kessels AG et al.: USPIO-enhanced MR imaging for nodal staging in patients with primary rectal cancer: predictive criteria. Radiology 246(3), 804-811 (2008). ■ Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MR is a useful technique to determine lymph node involvement.
68. Koh DM, Brown G, Temple L et al.: Rectal cancer: mesorectal lymph nodes at MRI with USPIO versus histopathologic findings - initial observations. Radiology 231, 91-99 (2004).
69. Will O, Purkayastha S, Chan C et al.: Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis. Lancet Oncol. 7(1), 52-60 (2006). ■ USPIO is sensitive and specific in the detection of lymph node metastasis for various tumors.
70. Hoh CK, Schiepers C, Seltzer MA et al.: PET in oncology: will it replace the other modalities? Semin. Nucl. Med. 27, 94-106 (1997).
71. Townsend DW: Positron emission tomography/computed tomography. Semin. Nucl. Med. 38(3), 152-166 (2008).
72. Llamas-Elvira JM, Rodríguez-Fernández A, Gutiérrez-Sáinz J et al.: Fluorine-18 fluorodeoxyglucose PET in the preoperative staging of colorectal cancer. Eur. J. Nucl. Med. Mol. Imaging 34(6), 859-867 (2007).
73. Tsunoda Y, Ito M, Fujii H, Kuwano H, Saito N: Preoperative diagnosis of lymph node metastases of colorectal cancer by FDG-PET/CT. Jpn. J. Clin. Oncol. 38(5), 347-353 (2008).
74. Koh DM, Brown G, Temple L et al.: Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur. Radiol. 15, 1650-1657 (2005).
75. Heriot AG, Hicks RJ, Drummond EG et al.: Does positron emission tomography change management in primary rectal cancer? A prospective assessment. Dis. Colon Rectum 47(4), 451-458 (2004). ■ Positron emission tomography (PET) accurately assesses the stage of rectal cancer and changes the stage of up to a third of patients with primary rectal cancer.
76. Berthelsen AK, Holm S, Loft A, Klausen TL, Andersen F, Højgaard L: PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients. Eur. J. Nucl. Med. Mol. Imaging 32(10), 1167-1175 (2005).
77. Nehmeh SA, Erdi YE, Kalaigian H et al.: Correction for oral contrast artifacts in CT attenuation-corrected PET images obtained by combined PET/CT. J. Nucl. Med. 44(12), 1940-1944 (2003).
78. Rappeport ED, Loft A, Berthelsen AK et al.: Contrast-enhanced FDG-PET/CT vs SPIO-enhanced MRI vs FDG-PET vs CT in patients with liver metastases from colorectal cancer: a prospective study with intraoperative confirmation. Acta Radiol. 48(4), 369-378 (2007).
79. Povoski SP, Fong Y, Sgouros SC, KemenyNE, Downey RJ, Blumgart LH: Role of chest CT in patients with negative chest x-rays referred for hepatic colorectal metastases. Ann. Surg Oncol. 5(1), 9-15 (1998).
80. Schima W, Kulinna C, Langenberger H, Ba-Ssalamah A: Liver metastases of colorectal cancer: US, CT or MR? Cancer Imaging 5(Spec. A), S149-S156 (2005).
81. Weg N, Scheer MR, Gabor MP: Liver lesions: improved detection with dual-detector-array CT and routine 2.5-mm thin collimation. Radiology 209(2), 417-426 (1998).
82. Kuszyk BS, Bluemke DA, Urban BA et al.: Portal-phase contrast-enhanced helical CT for the detection of malignant hepatic tumors: sensitivity based on comparison with intraoperative and pathologic findings. Am. J. Roentgenol. 166, 91-95 (1996).
83. Kinkel K, Lu Y, Both M, Warren RS, Thoeni R: Detection of hepatic metastasis from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-ana lysis. Radiology 224, 748-756 (2002).
84. Lauenstein TC, Goehde SC, Herborn CU et al.: Three-dimensional volumetric interpolated breath-hold MR imaging for whole-body tumor staging in less than 15 minutes: a feasibility study. Am. J. Roentgenol. 179(2), 445-449 (2002).
85. Hammerstingl R, Huppertz A, Breuer J et al.: European EOB-study group. Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions. Eur. Radiol. 18(3), 457-467 (2008).
86. Nahas CS, Akhurst T, Yeung H et al.: Positron emission tomography detection of distant metastatic or synchronous disease in patients with locally advanced rectal cancer receiving preoperative chemoradiation. Ann. Surg Oncol. 15(3), 704-711 (2008).
87. Davey K, Heriot AG, Mackay J et al.: The impact of 18-fluorodeoxyglucose positron emission tomography-computed tomography on the staging and management of primary rectal cancer. Dis. Colon Rectum 51(7), 997-1003 (2008).
88. Gearhart SL, Frassica D, Rosen R, Choti M, Schulick R, Wahl R: Improved staging with pretreatment positron emission tomography/ CT in low rectal cancer. Ann. Surg Oncol. 13(3), 397-404 (2006).
89. Bipat S, van Leeuwen MS, Comans EF et al.: Colorectal liver metastases: CT, MR imaging, and PET for diagnosis - meta-ana lysis. Radiology 237(1), 123-131 (2005).
90. Maretto I, Pomerri F, Pucciarelli S et al.: The potential of restaging in the prediction of pathologic response after preoperative chemoradiotherapy for rectal cancer. Ann. Surg Oncol. 14(2), 455-461 (2007).
91. Radovanovic Z, Breberina M, Petrovic T, Golubovic A, Radovanovic D: Accuracy of endorectal ultrasonography in staging locally advanced rectal cancer after preoperative chemoradiation. Surg. Endosc. 22(11), 2412-2415 (2008).
92. Chen CC, Lee RC, Lin JK, Wang LW, Yang SH: How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? Dis. Colon Rectum 48(4), 722-728 (2005).
93. Maor Y, Nadler M, Barshack I et al.: Endoscopic ultrasound staging of rectal cancer: diagnostic value before and following chemoradiation. J. Gastroenterol. Hepatol. 21(2), 454-458 (2006).
94. Salerno GV, Daniels IR, Moran BJ, Heald RJ, Thomas K, Brown G: Magnetic resonance imaging prediction of an involved surgical resection margin in low rectal cancer. Dis. Colon Rectum 52(4), 632-639 (2009).
95. Allen SD, Padhani AR, Dzik-Jurasz AS, Glynne-Jones R: Rectal carcinoma: MRI with histologic correlation before and after chemoradiation therapy. Am. J. Roentgenol. 188(2), 442-451 (2007).
96. Vliegen RF, Beets GL, Lammering G et al.: Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction. Radiology 246(2), 454-462 (2008).
97. Lahaye MJ, Beets GL, Engelen SM et al.: Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part II. What are the criteria to predict involved lymph nodes? Radiology 252(1), 81-91 (2009).
98. Dresen RC, Beets GL, Rutten HJ et al.: Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part I. Are we able to predict tumor confined to the rectal wall? Radiology 252(1), 71-80 (2009).
99. Chao KS: Functional imaging for early prediction of response to chemoradiotherapy: 3′-deoxy-3′-18F-fluorothymidine positron emission tomography - a clinical application model of esophageal cancer. Semin. Oncol. 33(6 Suppl. 11), S59-63 (2006).
100. Denecke T, Rau B, Hoffmann KT et al.: Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging? Eur. Radiol. 15(8), 1658-1666 (2005).
101. Kalff V, Ware R, Heriot A, Chao M, Drummond E, Hicks RJ: Radiation changes do not interfere with postchemoradiation restaging of patients with rectal cancer by FDG PET/CT before curative surgical therapy. Int. J. Radiat. Oncol. Biol. Phys. 74(1), 60-66 (2009).
102. Kalff V, Duong C, Drummond EG et al.: Findings on 18F-FDG PET scans after neoadjuvant chemoradiation provides prognostic stratification in patients with locally advanced rectal carcinoma subsequently treated by radical surgery. J. Nucl. Med. 47, 14-22 (2006).
103. Vriens D, de Geus-Oei LF, van der Graaf WT, Oyen WJ: Tailoring therapy in colorectal cancer by PET-CT. Q. J. Nucl. Med. Mol. Imaging 53(2), 224-244 (2009).
104. Zorcolo L, Fantola G, Cabras F, Marongiu L, D'Alia G, Casula G: Preoperative staging of patients with rectal tumors suitable for transanal endoscopic microsurgery (TEM): comparison of endorectal ultrasound and histopathologic findings. Surg. Endosc. 23(6), 1384-1389 (2009).
105. Knaebel HP, Koch M, Feise T, Benner A, Kienle P: Diagnostics of rectal cancer: endorectal ultrasound. Recent Results Cancer Res. 165, 46-57 (2005).
106. Manger T, Stroh C: Accuracy of endorectal ultrasonography in the preoperative staging of rectal cancer. Tech. Coloproctol. 8(Suppl. 1), S14-S15 (2004).
107. Nesbakken A, Løvig T, Lunde OC, Nygaard K: Staging of rectal carcinoma with transrectal ultrasonography. Scand. J. Surg. 92(2), 125-129 (2003).
108. Garcia-Aguilar J, Pollack J, Lee SH et al.: Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors. Dis. Colon Rectum 45(1), 10-15 (2002).
109. Marusch F, Koch A, Schmidt U et al.: Routine use of transrectal ultrasound in rectal carcinoma: results of a prospective multicenter study. Endoscopy 34(5), 385-390 (2002).
110. Kim CK, Kim SH, Choi D et al.: Comparison between 3-T magnetic resonance imaging and multidetector row computed tomography for the preoperative evaluation of rectal cancer. J. Comput. Assist. Tomogr. 31(6), 853-859 (2007).
111. Sinha R, Verma R, Rajesh A, Richards CJ: Diagnostic value of multidetector row CT in rectal cancer staging: comparison of multiplanar and axial images with histopathology. Clin. Radiol. 61(11), 924-931 (2006).
112. Harewood GC, Wiersema MJ, Nelson H et al.: A prospective, blinded assessment of the impact of preoperative staging on the management of rectal cancer. Gastroenterology 123(1), 24-32 (2002).
113. Chiesura-Corona M, Muzzio PC, Giust G et al.: Rectal cancer: CT local staging with histopathologic correlation. Abdom. Imaging 26(2), 134-138 (2001).
114. Halefoglu AM, Yildirim S, Avlanmis O, Sakiz D, Baykan A: Endorectal ultrasonography versus phased-array magnetic resonance imaging for preoperative staging of rectal cancer. World J. Gastroenterol. 14(22), 3504-3510 (2008).
115. Zhang XM, Zhang HL, Yu D et al.: 3-T MRI of rectal carcinoma: preoperative diagnosis, staging, and planning of sphinctersparing surgery. Am. J. Roentgenol. 190(5), 1271-1278 (2008).
116. Rao SX, Zeng MS, Xu JM et al.: Assessment of T staging and mesorectal fascia status using high-resolution MRI in rectal cancer with rectal distention. World J. Gastroenterol. 13(30), 4141-4146 (2007).
117. Tatli S, Mortele KJ, Breen EL, Bleday R, Silverman SG: Local staging of rectal cancer using combined pelvic phased-array and endorectal coil MRI. J. Magn. Reson. Imaging 23(4), 534-540 (2006).
118. Ferri M, Laghi A, Mingazzini P et al.: Preoperative assessment of extramural invasion and sphincteral involvement in rectal cancer by magnetic resonance imaging with phased-array coil. Colorectal Dis. 7(4), 387-393 (2005).
119. Mathur P, Smith JJ, Ramsey C et al.: Comparison of CT and MRI in the preoperative staging of rectal adenocarcinoma and prediction of circumferential resection margin involvement by MRI. Colorectal Dis. 5(5), 396-401 (2003).
120. Beets-Tan RG, Beets GL, Vliegen RF et al.: Accuracy of magnetic resonance imaging in prediction of tumor-free resection margin in rectal cancer surgery. Lancet 357(9255), 497-504 (2001). ■ Circumferential resection margin can be predicted with high accuracy and consistency in patients with rectal cancer surgery.
121. Blomqvist L, Machado M, Rubio C et al.: Rectal tumor staging: MR imaging using pelvic phased-array and endorectal coils versus endoscopic ultrasonography. Eur. Radiol. 10(4), 653-660 (2000).
122. Rappeport ED, Loft A: Liver metastases from colorectal cancer: imaging with superparamagnetic iron oxide (SPIO)-enhanced MR imaging, computed tomography and positron emission tomography. Abdom. Imaging 32(5), 624-634 (2007).
123. Valls C, Andía E, Sánchez A et al.: Hepatic metastases from colorectal cancer: preoperative detection and assessment of resectability with helical CT. Radiology 218(1), 55-60 (2001).
124. Squillaci E, Manenti G, Mancino S et al.: Staging of colon cancer: whole-body MRI versus whole-body PET-CT - initial clinical experience. Abdom. Imaging 33(6), 676-688 (2008).
125. Low RN, McCue M, Barone R, Saleh F, Song T: MR staging of primary colorectal carcinoma: comparison with surgical and histopathologic findings. Abdom. Imaging 28(6), 784-793 (2003).
126. Orlacchio A, Schillaci O, Fusco N et al.: Role of PET/CT in the detection of liver metastases from colorectal cancer. Radiol. Med. 114(4), 571-585 (2009).
127. Antoch G, Vogt FM, Freudenberg LS et al.: Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. JAMA 290(24), 3199-3206 (2003).