Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo

Eukaryotic Cell

Volumn 9, Issue 1, 2010, Pages 31-36

  Bao, Marie Z ^a,b   Shock, Teresa R ^a,c   Madhani, Hiten D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cell Press   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CDC4 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; F BOX PROTEIN; HYBRID PROTEIN; PEPTIDE; SACCHAROMYCES CEREVISIAE PROTEIN; TEC1 PROTEIN, S CEREVISIAE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; F-BOX PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

SACCHAROMYCES CEREVISIAE;

EID: 75649123435     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00250-09     Document Type: Article

References (10)

1. Bao, M. Z., M. A. Schwartz, G. T. Cantin, J. R. Yates III, and H. D. Madhani. 2004. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119:991-1000.
2. Chou, S., L. Huang, and H. Liu. 2004. Fus3-regulated Tec1 degradation through SCF(Cdc4) determines MAPK signaling specificity during mating in yeast. Cell 119:981-990.
3. Deshaies, R. J., and C. A. Joazeiro. 2009. RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 78:399-434.
4. Hao, B., S. Oehlmann, M. E. Sowa, J. W. Harper, and N. P. Pavletich. 2007. Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol. Cell 26:131-143.
5. Hodge, A., and M. Mendenhall. 1999. The cyclin-dependent kinase inhibitory domain of the yeast Sic1 protein is contained within the C-terminal 70 amino acids. Mol. Gen. Genet. 262:55-64.
6. Madhani, H. D., C. A. Styles, and G. R. Fink. 1997. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91:673-684.
7. Nash, P., X. Tang, S. Orlicky, Q. Chen, F. B. Gertler, M. D. Mendenhall, F. Sicheri, T. Pawson, and M. Tyers. 2001. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414:514-521.
8. Orlicky, S., X. Tang, A. Willems, M. Tyers, and F. Sicheri. 2003. Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell 112:243-256.
9. Pan, X., and J. Heitman. 1999. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:4874-4887.
10. Schwob, E., T. Bohm, M. D. Mendenhall, and K. Nasmyth. 1994. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in Saccharomyces cerevisiae. Cell 79:233-244.