Interference in an unconjugated estriol assay causing a false negative integrated prenatal screening report

Prenatal Diagnosis

Volumn 30, Issue 2, 2010, Pages 165-167

  Dennis, Alan William ^a   Siu, Victoria Mok ^a   Campagnolo, Carla ^a   Soldin, Steven J ^b  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Fetal and placental pathology; General cytogenetics; Genetic counselling; Maternal serum screening; Prenatal cytogenetics; Psychosocial, legal and ethical

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN; ESTRIOL; HETEROPHILE ANTIBODY; INHIBIN A; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; AMNIOCENTESIS; ANTIBODY DETECTION; ARTICLE; BLOOD SAMPLING; CASE REPORT; DOWN SYNDROME; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE NEGATIVE RESULT; FEMALE; HUMAN; PREGNANCY TERMINATION; PRENATAL CARE; PRENATAL SCREENING; PRIORITY JOURNAL; PROTEIN DETERMINATION; RISK ASSESSMENT; SEX HORMONE DETERMINATION;

ADULT; ALPHA-FETOPROTEINS; CHORIONIC GONADOTROPIN; DOWN SYNDROME; ESTRIOL; FALSE NEGATIVE REACTIONS; FEMALE; HUMANS; NUCHAL TRANSLUCENCY MEASUREMENT; PREGNANCY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A;

EID: 75649097092     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2426     Document Type: Article

References (13)

1. Butler SA, Cole LA. 2001. Use of heterophilic antibody blocking agent (HBT) in reducing false positive hCG results. Clin Chem 47: 1332-1333.
2. Ekins R. 1987. Validity of analogue free thyroxine immunoassays. Clin Chem 33: 2137-2144.
3. Emerson JF, Ngo G, Emerson SS. 2003. Screening for interference in immunoassays. Clin Chem 49: 1163-1169.
4. Guo T, Gu J, Soldin OP, Singh RJ, Soldin SJ. 2008. Rapid measurement of estrogens and their metabolites in human serum by liquid chromatography-tandem mass spectrometry without derivatization. Clin Biochem 41: 736-741.
5. Klee GG. 2000. Human anti-mouse antibodies. Arch Pathol Lab Med 124: 921-923.
6. Kricka LJ. 1999. Human anti-animal antibody interferences in immunological assays. Clin Chem 45: 942-956.
7. Kricka LJ. 2000. Interferences in immunoassay-still a threat. Clin Chem 46: 1037-1038.
8. Lambert-Messerlian G, Bandera C, Eklund E, Neuhauser A, Canick J. 2007. Very high Inhibin A concentration attributed to Heterophilic Antibody Interference. Clin Chem 53: 800-801.
9. Levinson SS. 1992. The nature of heterophilic antibodies and their role in immunoassay interference. J Clin Immunoassay 15: 108-115.
10. Soldin OP, Hilakivi-Clarke L,Weiderpass E, Soldin SJ. 2004 Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays. Clin Chim Acta 349: 181-189.
11. Soldin SJ, et al. 2005. The measurement of free thyroxine by isotope dilution tandem mass spectrometry. Clin Chim Acta 358: 113-118.
12. Summers AM, Huang T, Boucher K, et al. 2008. Integrated prenatal screening in Ontario since 1999. 8th International Congress of International Down Syndrome Screening Group. Vancouver. May 31-June 1, 2008.
13. Wald NJ, Rodeck C, Hackshaw AK, Walters J, Chitty L, Mackinson AM. 2003. First and second trimester antenatal screening for Down's syndrome: the results of the serum, urine and ultrasound screening study (SURUSS). J Med Screen 10: 56-104.