Failure to detect Borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients

Psychiatry Investigation

Volumn 6, Issue 4, 2009, Pages 306-312

  Na, Kyoung Sae ^a   Tae, Seong Ho ^a   Song, Jin Won ^a   Kim, Yong Ku ^a,b  

^a Korea University College of Medicine   (South Korea)

^b Korea University   (South Korea)

Author keywords

Borna disease virus; Peripheral blood mononuclear cell; Psychiatric disorders; Real time reverse transcriptase polymerase chain reaction

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; BORNA DISEASE VIRUS; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SEX DIFFERENTIATION; VIRUS DETECTION;

EID: 75649096391     PISSN: 17383684     EISSN: None     Source Type: Journal    
DOI: 10.4306/pi.2009.6.4.306     Document Type: Article

References (67)

1. Yolken RH, Torrey EF. Viruses, schizophrenia, and bipolar disorder. Clin Microbiol Rev 1995;8:131-145.
2. de la Torre JC. Molecular biology of borna disease virus: prototype of a new group of animal viruses. J Virol 1994;68:7669-7675.
3. Kohno T, Goto T, Takasaki T, Morita C, Nakaya T, Ikuta K, et al. Fine structure and morphogenesis of Borna disease virus. J Virol 1999;73:760-766.
4. Gonzalez-Dunia D, Sauder C, de la Torre JC. Borna disease virus and the brain. Brain Res Bull 1997;44:647-664.
5. Okamoto M, Furuoka H, Hagiwara K, Kamitani W, Kirisawa R, Ikuta K, et al. Borna disease in a heifer in Japan. Vet Rec 2002;150:16-18.
6. Richt JA, Pfeuffer I, Christ M, Frese K, Bechter K, Herzog S. Borna disease virus infection in animals and humans. Emerg Infect Dis 1997;3:343-352.
7. Rott R, Becht H. Natural and experimental Borna disease in animals. Curr Top Microbiol Immunol 1995;190:17-30.
8. Watanabe Y, Yanai H, Ohtaki N, Ikuta K, Tomonaga K. Prevalence of Borna disease virus antibodies in healthy Japanese black cattle in Kyushu. J Vet Med Sci 2006:68:171-174.
9. Briese T, Hornig M, Lipkin Wl. Bornavirus immunopathogenesis in rodents: models for human neurological diseases. J Neurovirol 1999;5:604-612.
10. Pletnikov MV, Moran TH, Carbone KM. Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. Front Biosci 2002;7:d593-d607.
11. Lancaster K, Dietz DM, Moran TH, Pletnikov MV. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behav Brain Res 2007;176:141-148.
12. Bautista JR, Rubin SA, Moran TH, Schwartz GJ, Carbone KM. Developmental injury to the cerebellum following perinatal Borna disease virus infection. Brain Res Dev Brain Res 1995;90:45-53.
13. Nakamura Y, Takahashi H, Shoya Y, Nakaya T, Watanabe M, Tomonaga K, et al. Isolation of Borna disease virus from human brain tissue. J Virol 2000;74:4601-4611.
14. Hornig M, Solbrig M, Horscroft N, Weissenböck H, Lipkin WI. Borna disease virus infection of adult and neonatal rats: models for neuropsychiatrie disease. Curr Top Microbiol Immunol 2001;253:157-177.
15. Ovanesov MV, Moldovan K, Smith K, Vogel MW, Pletnikov MV. Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus. J Neuroinflammation 2008;5:16.
16. Volmer R, Prat CM, Le Masson G, Garenne A, Gonzalez-Dunia D. Borna disease virus infection impairs synaptic plasticity. J Virol 2007;81:8833-8837.
17. Williams BL, Lipkin WI. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. J Virol 2006;80:8613-8626.
18. Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, et al. Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 1985;228:755-756.
19. Bode L, Zimmermann W, Ferszt R, Steinbach F, Ludwig H. Borna disease virus genome transcribed and expressed in psychiatric patients. Nat Med 1995;1:232-236.
20. Vahlenkamp TW, Enbergs HK, Müller H. Experimental and natural boma disease virus infections: presence of viral RNA in cells of the peripheral blood. Vet Microbiol 2000;76:229-244.
21. Lebain P, Vabret A, Freymuth F, Brazo P, Chabot B, Dollfus S, et al. Borna disease virus and psychiatric disorders. Schizophr Res 2002;57:303-305.
22. Kinnunen PM, Billich C, Ek-Kommonen C, Henttonen H, Kallio RK, Niemimaa J, et al. Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland. J Clin Virol 2007;38:64-69.
23. Miranda HC, Nunes SO, Calvo ES, Suzart S, ltano EN, Watanabe MA. Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients. J Affect Disord 2006;90:43-47.
24. Nunes SO, ltano EN, Amarante MK, Reiche EM, Miranda HC, de Oliveira CE, et al. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. J Clin Lab Anal 2008;22:314-320.
25. Rybakowski F, Sawada T, Yamaguchi K. Borna disease virus-reactive antibodies and recent-onset psychiatric disorders. Eur Psychiatry 2001;16:191-192.
26. Terayama H, Nishino Y, Kishi M, Ikuta K, Itoh M, Iwahashi K. Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. Psychiatry Res 2003;120:201-206.
27. Schwemmle M. Borna disease virus infection in psychiatric patients: are we on the right track? Lancet Infect Dis 2001;1:46-52.
28. Espy MJ, UhI JR, Sloan LM, Buckwalter SP, Jones MF, Vetter EA, et al. Real-time PCR in clinical microbiology: applications for routine laboratory testing. Clin Microbiol Rev 2006;19:165-256.
29. Watzinger F, Ebner K, Lion T. Detection and monitoring of virus infections by real-time PCR. Mol Aspects Med 2006;27:254-298.
30. Sorg I, Metzler A. Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR. J Clin Microbiol 1995;33:821-823.
31. Wensman JJ, Thorén P, Hakhverdyan M, Belák S, Berg M. Development of a real-time RT-PCR assay for improved detection of Borna disease virus. J Virol Methods 2007;143:1-10.
32. Schindler AR, Vögtlin A, Hilbe M, Puorger M, Zlinszky K, Ackermann M, et al. Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts. Mol Cell Probes 2007;21:47-55.
33. Wolff T, Heins G, Pauli G, Burger R, Kurth R. Failure to detect Borna disease virus antigen and RNA in human blood. J Clin Virol 2006;36:309-311.
34. APA. Diagnostic and statistical manual of mental disorders IV. American Psychiatric Association, Washington, D.C.; 1994.
35. Herzog S, Rott R. Replication of Borna disease virus in cell cultures. Med Microbiol Immunol 1980;168:153-158.
36. Watanabe M, Lee BJ, Kamitani W, Kobayashi T, Taniyama H, Tomonaga K, et al. Neurological diseases and viral dynamics in the brains of neonatally borna disease virus-infected gerbils. Virology 2001;282:65-76.
37. Kim YK, Kim SH, Han CS, Lee HJ, Kim HS, Yoon SC, et al. Borna disease virus and deficit schizophrenia. Acta Neuropsychiatr 2003;15:262-265.
38. Kim YK, Kim SH, Choi SH, Ko YH, Kim L, Lee MS, et al. Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea. J Neurovirol 1999;5:196-199.
39. Bachmann S, Caplazi P, Fischer M, Ehrensperger F, Cone RW. Lack of association between Borna disease virus infection and neurological disorders among HIV-infected individuals. J Neurovirol 1999;5:190-195.
40. Richt JA, Alexander RC, Herzog S, Hooper DC, Kean R, Spitsin S, et al. Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders. J Neurovirol 1997;3:174-178.
41. Lieb K, Hallensieben W, Czygan M, Stitz L, Staeheli P. No Borna disease virus-specific RNA detected in blood from psychiatric patients in different regions of Germany. The Bornavirus Study Group. Lancet 1997;350:1002.
42. Tsuji K, Toyomasu K, Imamura Y, Maeda H, Toyoda T. No association of borna disease virus with psychiatric disorders among patients in northern Kyushu, Japan. J Med Virol 2000;61:336-340.
43. Staeheli P, Sauder C, Hausmann J, Ehrensperger F, Schwemmle M. Epidemiology of Borna disease virus. J Gen Virol 2000;81:123-2135.
44. Schwemmle M, Jehle C, Formella S, Staeheli P. Sequence similarities between human bornavirus isolates and laboratory strains question human origin. Lancet 1999;354:1973-1974.
45. Dürrwald R, Kolodziejek J, Herzog S, Nowotny N. Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness. Rev Med Virol 2007;17:181-203.
46. Sauder C, Müller A, Cubitt B, Mayer J, Steinmetz J, Trabert W, et al. Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. J Virol 1996;70:7713-7724.
47. Igata-Yi R, Yamaguchi K, Yoshiki K, Takemoto S, Yamasaki H, Matsuoka M, et al. Borna disease vims and the consumption of raw horse meat. Nat Med 1996;2:948-949.
48. Allmang U, Hofer M, Herzog S, Bechter K, Staeheli P. Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Mol Psychiatry 2001;6:329-333.
49. Inoue Y, Yamaguchi K, Sawada T, Rivera JC, Horii Y. Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001. J Vet Med Sci 2002;64:445-448.
50. Matsunaga H, Tanaka S, Fukumori A, Tomonaga K, Ikuta K, Amino N, et al. Isotype analysis of human anti-Boma disease virus antibodies in Japanese psychiatric and general population. J Clin Virol 2008;43:317-322.
51. Kishi M, Nakaya T, Nakamura Y, Kakinuma M, Takahashi TA, Sekiguchi S, et al. Prevalence of Borna disease virus RNA in peripheral blood mononuclear cells from blood donors. Med Microbiol Immunol 1995;184:135-138.
52. Kishi M, Nakaya T, Nakamura Y, Zhong Q, Ikeda K, Senjo M, et al. Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells. FEBS Lett 1995;364:293-297.
53. Nakaya T, Takahashi H, Nakamura Y, Asahi S, Tobiume M, Kuratsune H, et al. Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome. FEBS Lett 1996;378:145-149.
54. Iwahashi K, Watanabe M, Nakamura K, Suwaki H, Nakaya T, Nakamura Y, et al. Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan. Acta Psychiatr Scand 1997;96:412-415.
55. Kubo K, Fujiyoshi T, Yokoyama MM, Kamei K, Rieht JA, Kitze B, et al. Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients. Clin Diagn Lab Immunol 1997;4:189-194.
56. Takahashi H, Nakaya T, Nakamura Y, Asahi S, Onishi Y, Ikebuchi K, et al. Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms. J Med Virol 1997;52:330-335.
57. Iwata Y, Takahashi K, Peng X, Fukuda K, Ohno K, Ogawa T, et al. Detection and sequence analysis of borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. J Virol 1998;72:10044-10049.
58. Planz O, Rentzsch C, Batra A, Rziha HJ, Stitz L. Persistence of Borna disease virus-specific nucleic acid in blood of psychiatric patient. Lancet 1998;352:623.
59. Planz O, Rentzsch C, Batra A, Winkler T, Büttner M, Rziha HJ, et al. Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral anti-bodies. J Virol 1999;73:6251-6256.
60. Chen CH, Chiu YL, Shaw CK, Tsai MT, Hwang AL, Hsiao KJ. Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers. Mol Psychiatry 1999;4:566-571.
61. Nakaya T, Takahashi H, Nakamur Y, Kuratsune H, Kitani T, Machii T, et al. Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome. Microbiol Immunol 1999;43:679-689.
62. Evengârd B, Briese T, Lindh G, Lee S, Lipkin WI. Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome. J Neurovirol 1999;5:495-499.
63. Nowotny N, Kolodziejek J. Demonstration of boma disease virus nucleic acid in a patient with chronic fatigue syndrome. J Infect Dis 2000;181:1860-1862.
64. Fukuda K, Takahashi K, Iwata Y, Mori N, Gonda K, Ogawa T, et al. Immunological and PCR analyses for Boma disease virus in psychia-tric patients and blood donors in Japan. J Clin Microbiol 2001;39:419-429.
65. Kim YK, Kim SH, Han CS, Lee HJ, Kim HS, Yoon SC, et al. Borna disease virus and deficit schizophrenia. Acta Neuropsychiatr 2003;15:262-265.
66. Li Q, Wang Z, Zhu D, Xu M, Chen X, Peng D, et al. Detection and analysis of Borna disease virus in Chinese patients with neurological disorders. Eur J Neurol 2009;16:399-403.
67. Lieb K, Staeheli P. Borna disease virus-does it infect humans and cause psychiatric disorders? J Clin Virol 2001;21:119-127.