Treatment of trichomoniasis in pregnancy in sub-Saharan Africa does not appear to be associated with low birth weight or preterm birth

South African Medical Journal

Volumn 100, Issue 1, 2010, Pages 58-64

  Stringer, Elizabeth ^a,b   Read, Jennifer S ^c   Hoffman, Irving ^d   Valentine, Megan ^e   Aboud, Said ^f   Goldenberg, Robert L ^g  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b CENTRE FOR INFECTIOUS DISEASE RESEARCH IN ZAMBIA   (Zambia)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e FAMILY HEALTH INTERNATIONAL   (United States)

^f MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^g DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ERYTHROMYCIN; METRONIDAZOLE; PLACEBO;

ADULT; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; DELIVERY; DISEASE TRANSMISSION; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; PREGNANCY; PREMATURE LABOR; SCORING SYSTEM; SOUTH AFRICA; TRICHOMONIASIS;

ADULT; AFRICA SOUTH OF THE SAHARA; ANTI-INFECTIVE AGENTS; COHORT STUDIES; ERYTHROMYCIN; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; METRONIDAZOLE; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PREMATURE BIRTH; TREATMENT OUTCOME; TRICHOMONAS VAGINALIS; TRICHOMONAS VAGINITIS; YOUNG ADULT;

EID: 75649094534     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hack M, Fanaroff AA. Outcomes of extremely premature infants: a perinatal dilemma. N Engl J Med 1993; 329: 1649-1650.
2. Kulmala T, Vaahtera M, Ndekha M, et al. The importance of preterm births for peri- and neonatal mortality in rural Malawi. Paediatr Perinatal Epidemiol 2000; 14(3): 219-226.
3. Hillier SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 1995; 333(26): 1737-1742.
4. Gravett M, Nelson HP, DeRouen T, Critchlow C, Eschenbach DA, Holmes KK. Independent associations of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcome. JAMA 1986; 256(14): 1899-1903.
5. Cotch MF, Pastorek JG, Nugent RP, et al. Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group. Sex Transm Dis 1997; 24(6): 353-350.
6. Buve A, Weiss HA, Laga M, et al. The epidemiology of trichomoniasis in women in four African cities. AIDS 2001; 15: Suppl 4, S89-S96.
7. Price MA, Zimba D, Hoffman IF, Kaydos-Daniels SC, Miller WC, Martinson F. Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial. Sex Transm Infect 2003; 30(6): 516-522.
8. Watson-Jones D, Mugeye K, Mayaud P, Ndeki L, Todd J, Mosha F. High prevalence of trichomoniasis in rural men in Mwanza, Tanzania: results from a population based study. Sex Transm Infect 2000; 76: 355-362.
9. Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995; 333(26): 1732-1736.
10. Lamont RF. Can antibiotics prevent preterm birth - the pro and con debate. BJOG 2005; 112: Suppl 1, 67-73.
11. Hutzal CE, Boyle EM, Kenyon SL, et al. Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis. Am J Obstet Gynecol 2008; 199(6): 620.E1-8.
12. Klebanoff MA, Carey JC, Hauth JC, et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 2001; 345: 487-493.
13. Kigozi GG, Brahmbhatt H, Wabwire-Mangen F, et al. Treatment of Trichomonas in pregnancy and adverse outcomes in pregnancy: a subanalysis of a randomized trial in Rakai, Uganda. Am J Obstet Gynecol 2003; 189(5): 1398-1400.
14. Taha TE, Brown ER, Hoffman IF, et al. A phase III clinical trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmission. AIDS 2006; 20(9): 1313-1321.
15. Goldstein EJC, Citron DM, Cherubin CE, Hillier SL. Comparative susceptibility of the Bacteroides fragilis group species and other anaerobic bacteria to meropenem, imipenem, piperacillin, cefoxitin, ampicillin/sulbactam, clindamycin and metronidazole. J Antimicrob Chemother 1993; 31(3): 363-372.
16. Ballard JL, Novak KK, Driver MA. A simplified score for assessment of fetal maturity of newly born infants. J Pediatr 1979; 95(5, Pt I): 769-774.
17. Herruzo AJ, Martinez L, Biel E, Robles R, Rosales MA, Miranda JA. Perinatal morbidity and mortality in twin pregnancies. Int J Gynaecol Obstet 1991; 36(1): 17-22.
18. Okun N, Gronau KA, Hannah ME. Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: A systematic review. Obstet Gynecol 2005; 105: 857-868.
19. Ross SM, Middelkoop A. Trichomonas infection in pregnancy: does it affect perinatal outcome? S Afr Med J 1983; 63: 566-567.